Dermoscopy of small size basal cell carcinoma: a case-control study.

Dermoscopy of small size basal cell carcinoma: a case-control study.

J Eur Acad Dermatol Venereol. 2016 Sep 29;

Authors: Longo C, Specchio F, Ribero S, Coco V, Kyrgidis A, Moscarella E, Ragazzi M, Peris K, Argenziano G

Abstract
BACKGROUND: Several dermoscopic criteria for diagnosing BCC have been identified over the last years with the aim to help recognition of the tumour among others entities. However, few literature data are available regarding the identification of specific diagnostic criteria of small size BCCs OBJECTIVES: the aims of this study were 1) to investigate whether small size BCCs (<5 mm) are typified by specific dermoscopic criteria compared to larger BCCs (>5 mm) in a consecutive cohort of excised lesions and 2) to explore whether small BCCs belong to distinct histologic subtype METHODS: Histopathologically proven BCCs with a full set of clinical and dermoscopic images were retrieved in order to have a case-control study of small (<5mm in size) and large (>5mm in size) tumors.
RESULTS: Our study population included 87 small-size BCCs (cases) and an equal number of larger BCCs (controls). Small BCC were more frequent in younger patients (mean age 59.19 +/- 13.7 years) than controls (68.18 +/- 14.8 years) (p<0.001). Furthermore, Small BCCs were more frequently present on head and neck area (60%) compared to large BCCs (40%) (p=0.006). At univariate logistic regression, predictors of small BCC (Fig 1 and Table 2) were multiple blue grey dots (OR 1.319519; 95% CI 0.591-2.942) and large blue-gray ovoid nests (OR 1.506518; 95% CI 0.703-3.227). Interestingly, small BCCs were associated with a crude 3.5-fold higher odd of being nodular (OR 3.486; 95% CI 1.860-6.532).
CONCLUSIONS: Dermoscopy is as a reliable tool for the diagnosis of small BCC that could be regarded as a "miniaturized" BCC. According to our findings, the detection of a small nodule on the head-neck region dermoscopically typified by blue-grey ovoid nests and multiple blue grey dots is strongly suggestive of small BCC. This article is protected by copyright. All rights reserved.

PMID: 27685248 [PubMed - as supplied by publisher]

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