Mechanisms of nonsteroidal anti-inflammatory drugs in cancer prevention.

Mechanisms of nonsteroidal anti-inflammatory drugs in cancer prevention.

Semin Oncol. 2016 Feb;43(1):65-77

Authors: Umar A, Steele VE, Menter DG, Hawk ET

Abstract
Various clinical and epidemiologic studies show that nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin and cyclooxygenase inhibitors (COXIBs) help prevent cancer. Since eicosanoid metabolism is the main inhibitory targets of these drugs the resulting molecular and biological impact is generally accepted. As our knowledge base and technology progress we are learning that additional targets may be involved. This review attempts to summarize these new developments in the field.

PMID: 26970125 [PubMed - as supplied by publisher]

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