The real-time simulation of large-scale subthalamic nucleus (STN)-external globus pallidus (GPe) network model is of great significance for the mechanism analysis and performance improvement of deep brain stimulation (DBS) for Parkinson's states. This paper implements the real-time simulation of a large-scale STN-GPe network containing 512 single-compartment Hodgkin-Huxley type neurons on the Altera Stratix IV field programmable gate array (FPGA) hardware platform. At the single neuron level, some resource optimization schemes such as multiplier substitution, fixed-point operation, nonlinear function approximation and function recombination are adopted, which consists the foundation of the large-scale network realization. At the network level, the simulation scale of network is expanded using module reuse method at the cost of simulation time. The correlation coefficient between the neuron firing waveform of the FPGA platform and the MATLAB software simulation waveform is 0.9 756. Under the same physiological time, the simulation speed of FPGA platform is 75 times faster than the Intel Core i7-8700K 3.70 GHz CPU 32GB RAM computer simulation speed. In addition, the established platform is used to analyze the effects of temporal pattern DBS on network firing activities. The proposed large-scale STN-GPe network meets the need of real time simulation, which would be rather helpful in designing closed-loop DBS improvement strategies.
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