Παρασκευή, 3 Ιανουαρίου 2020

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com, Telephone consultation 11855 int 1193,


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Improving the sensitivity of an hsp20 -based PCR for genus detection of Leishmania parasites in cutaneous clinical samples: a proof of concept: AbstractLeishmaniasis is a parasitic disease of medical importance widely distributed around the world. Several methods are available for diagnosis but molecular approaches are highly recommended. To improve the sensitivity of an existing hsp20 gene based-PCR protocol to detect Leishmania parasites, primers were redesigned to amplify a shorter fragment using...
Functional, physical and psychosocial impact of Temporomandibular Disorders in adolescents and young adults.: Related ArticlesFunctional, physical and psychosocial impact of Temporomandibular Disorders in adolescents and young adults.Med Oral Patol Oral Cir Bucal. 2020 Jan 01;:Authors: Yap AU, Qiu LY, Natu VP, Wong MCAbstract BACKGROUND: This community-based study investigated the functional, physical and psychosocial impact of Temporomandibular Disorders (TMDs) in adolescents and young adults....
Epidermal and Dermal Hallmarks of Photoaging are Prevented by Treatment with Night Serum Containing Melatonin, Bakuchiol, and Ascorbyl Tetraisopalmitate: In Vitro and Ex Vivo Studies: AbstractIntroductionPhotoaging is a complex process that is chiefly the result of oxidative stress caused by ultraviolet (UV)-generated reactive oxygen species. To counter this process, we developed a 3-in-1 night facial serum (3-in-1 NFS) containing a combination of direct and indirect antioxidants and polyphenols...
Effect of probiotics as a complement to non-surgical periodontal therapy in chronic periodontitis: a systematic review.: Related ArticlesEffect of probiotics as a complement to non-surgical periodontal therapy in chronic periodontitis: a systematic review.Med Oral Patol Oral Cir Bucal. 2020 Jan 01;:Authors: Vives-Soler A, Chimenos-Küstner EAbstract BACKGROUND: To improve the results of the classic periodontal treatment, probiotics have been suggested recently to decrease the number of bacteria...
Levofloxacin versus placebo for the treatment of latent tuberculosis among contacts of patients with multidrug-resistant tuberculosis (the VQUIN MDR trial): a protocol for a randomised controlled trial: IntroductionTreatment of latent tuberculosis infection (LTBI) plays a substantial role in the prevention of drug-susceptible tuberculosis (TB). However, clinical trials to evaluate the efficacy of preventive therapy for presumed multidrug-resistant (MDR) LTBI are lacking. This trial aims to evaluate...
Association between birth weight and neurodevelopment at age 1-6 months: results from the Wuhan Healthy Baby Cohort: ObjectiveThe association between birth weight and infants' neurodevelopment is not well understood. We aimed to examine the impact of birth weight on neurodevelopment of infants at age 1–6 months using data from the Wuhan Healthy Baby Cohort (WHBC) study.Setting and participantsThis is a prospective cohort study of 4026 infants from the WHBC study who were born at the Women and Children's...
Recent trends in seroprevalence of rubella in Korean women of childbearing age: a cross-sectional study: ObjectivesThe aim of this study was to investigate the immunity against rubella using the serological status of rubella-specific IgG antibodies (antirubella IgG) in Korean women of childbearing age (15–49 years).DesignRetrospective cross-sectional study.SettingPopulation-based cross-sectional study in South Korea.ParticipantsBetween January 2010 and December 2017, test results from Korean women...
Influence of combined exposure to perceived risk at work and unstable employment on self-rated health: a comparison of two cross-sectional surveys in Europe and Korea: ObjectivesThe purpose of this study was to investigate the combined effect of exposure to perceived risk at work and unstable employment on self-rated health in both Korea and the European Union.DesignCross-sectional study.SettingWe conducted the analyses using employees data from the third Korean Working Conditions Survey (KWCS) conducted...
All-cause mortality following low-dose aspirin treatment for patients with high cardiovascular risk in remote Australian Aboriginal communities: an observational study: ObjectivesTo evaluate the benefit and risk of low-dose acetylsalicylic acid (aspirin) in patients from remote Aboriginal communities in the Northern Territory, Australia.DesignRetrospective cohort study using primary care and hospital data routinely used for healthcare. Aspirin users and non-users were compared before and after controlling...
Azithromycin as an add-on treatment for persistent uncontrolled asthma in adults: protocol of a systematic review and meta-analysis: IntroductionClinical management of asthma remains a public challenge. Despite standard treatment with inhaled corticosteroids (ICS) and long-acting beta-agonists (LABAs), asthma remains uncontrolled in a substantial number of chronic asthma patients who risk reduced lung function and severe exacerbations. Azithromycin could have add-on effects for these patients. This...
Potentially inappropriate prescribing in dementia: a state-of-the-art review since 2007: ObjectivesDementia frequently occurs alongside comorbidities. Coexisting conditions are often managed with multiple medications, leading to increased risk of potentially inappropriate medication and adverse drug reactions. We aimed to estimate prevalence of, and identify factors reported to be associated with, potentially inappropriate prescribing (PIP) for older individuals diagnosed with dementia.DesignWe used...
Engineering viable foot-and-mouth disease viruses with increased acid stability facilitate the development of improved vaccines: AbstractFoot-and-mouth disease virus (FMDV), the most acid-unstable virus among picornaviruses, tends to disassemble into pentamers at pH values slightly below neutrality. However, the structural integrity of intact virion is one of the most important factors that influence the induction of a protective antibody response. Thus, improving the acid stability of FMDV is required...
Effects of tai chi on postural control during dual-task stair negotiation in knee osteoarthritis: a randomised controlled trial protocol: IntroductionStair ascent and descent require complex integration between sensory and motor systems; individuals with knee osteoarthritis (KOA) have an elevated risk for falls and fall injuries, which may be in part due to poor dynamic postural control during locomotion. Tai chi exercise has been shown to reduce fall risks in the ageing population and is recommended...
A new high-yielding antimicrobial peptide NZX and its antibacterial activity against Staphylococcus hyicus in vitro/vivo: AbstractStaphylococcus hyicus, considered as a leading pathogen of exudative epidermitis, is a serious threat to humans and animals. The emergency of bacterial resistance to antibiotics, especially in human and animal health fields, leads to an urgent need of exploration of new antimicrobial agents. In this study, NZX, a plectasin-derived peptide, was firstly expressed in Pichia...
Penicillin and cephalosporin biosyntheses are also regulated by reactive oxygen species: AbstractIn an earlier work on lovastatin production by Aspergillus terreus, we found that reactive oxygen species (ROS) concentration increased to high levels precisely at the start of the production phase (idiophase) and that these levels were sustained during all idiophase. Moreover, it was shown that ROS regulate lovastatin biosynthesis. ROS regulation has also been reported for aflatoxins. It has been suggested...
The North Texas Concussion Registry (ConTex): PurposeThe North Texas Concussion Registry (ConTex) was established in 2015 as a multi-institutional collaboration intended to study risk factors, recovery patterns and clinical outcomes associated with concussion across the lifespan, with a particular emphasis on sport-related concussion.ParticipantsProspective enrolment of individuals who sustained a concussion within the past 6 months who were seen at one of four North Texas ConTex concussion clinics...
Nanomaterials: new weapons in a crusade against phytopathogens: AbstractBacteria, fungi, viruses, and nematodes are the major causal agents of plant diseases. These phytopathogens are responsible for about 10–40% losses in productivity and quality of food crops and horticultural produce. Although eradication of pathogens is not possible, control of plant diseases has been an area of continuous improvement/research. Use of antimicrobials, bacteriophages, and biocontrol agents, natural and synthetic...
A pH-responsive genetic sensor for the dynamic regulation of D-xylonic acid accumulation in Escherichia coli: AbstractThe xylose oxidative pathway (XOP) is continuously gaining prominence as an alternative for the traditional pentose assimilative pathways in prokaryotes. It begins with the oxidation of D-xylose to D-xylonic acid, which is further converted to α-ketoglutarate or pyruvate + glycolaldehyde through a series of enzyme reactions. The persistent drawback of XOP is the accumulation of D-xylonic...
Antibodies generated against dextransucrase exhibit potential anticariostatic properties in Streptococcus mutans: AbstractStreptococcus mutans is a common principal causative agent of dental caries. In this communication, we describe that the antibodies raised against purified dextransucrase effectively inhibited the growth of S. mutans. The purified enzyme showed 58-fold enrichment, 17.5% yield and a specific activity of 3.96 units/mg protein. Purified IgG fraction of the antibody showed significant...
Construction and characterization of a chimeric lysin ClyV with improved bactericidal activity against Streptococcus agalactiae in vitro and in vivo: AbstractThe emergence of antibiotic-resistant beta-hemolytic Streptococcus agalactiae strains poses increasing threat to human beings globally. As an attempt to create a novel lysin with improved activity against S. agalactiae, a chimeric lysin, ClyV, was constructed by fusing the enzymatically active domain (EAD) from PlyGBS lysin (GBS180) and the...
Aripiprazole for prevention of delirium in the neurosurgical intensive care unit: a double-blind, randomized, placebo-controlled study: AbstractPurposeDelirium is reported in over 50% of critically ill ICU patients, and is associated with increased mortality and long-term cognitive consequences. Prevention and early management of delirium are essential components of ICU care. However, pharmacological interventions have not been effective in delirium prevention. This study investigated the effect...
Stress responses linked to antimicrobial resistance in Acinetobacter species: AbstractSince the last 20 years, bacteria of the genus Acinetobacter have been the leading cause of hospital-acquired infections. In addition to the ability of Acinetobacter species to acquire rapid antibiotic resistance, limited knowledge on the mechanisms of multidrug resistance to antibiotics limits the treatment options for such infections. Here, we present a review of cellular processes, including oxidative stress...
Identification and characterisation of common glow-worm RNA viruses: AbstractThe common glow-worms (Lampyris noctiluca) are best known for emission of green light by their larvae and sexually active adult females. However, both their DNA and RNA viruses remain unknown. Glow-worms are virologically interesting, as they are non-social and do not feed as adults, and hence their viral transmission may be limited. We identified viral sequences from 11 different virus taxa by the RNA-sequencing of two...
Exogenous abscisic acid suppresses the lignification and changes the growth, root anatomical structure and related gene profiles of carrot: Plant hormones are essential elements that control a great number of cellular processes that occur during plant growth. Abscisic acid (ABA) is a plant hormone known for its roles in regulating growth/development and response to biotic/abiotic stresses of the plant. It modulates plant growth and development in many aspects, such as seed dormancy, stomata movement,...
Comprehension of written texts for the assessment of clinical competence and decision making in people with mild to moderate Alzheimer disease: AbstractBackgroundClinical competence is the term used to describe an individual's capacity to express a choice regarding their participation in clinical procedures or experimental studies. Understanding the information provided is a prerequisite but consent forms are often lengthy and complicated. Alzheimer's disease patients may be vulnerable in written...
Light emitting diode (LED) based fluorescence microscopy for tuberculosis detection: a review: AbstractSince time immemorial, tuberculosis (TB) has intimidated the human race owing to its severity. Its socio-economic burden has led to it being a major cause of concern. It is one of the world's major causes of death from a single agent. Since most of the middle- and low-income countries are burdened with TB, sputum smear examination using conventional light microscopy is often the only resort for...
The Phosphatase PHLPP2 Plays a Key Role in the Regulation of Pancreatic Beta-Cell Survival: Currently available antidiabetic treatments fail to halt, and may even exacerbate, pancreatic β-cell exhaustion, a key feature of type 2 diabetes pathogenesis; thus, strategies to prevent, or reverse, β-cell failure should be actively sought. The serine threonine kinase Akt has a key role in the regulation of β-cell homeostasis; among Akt modulators, a central role is played by pleckstrin homology domain leucine-rich...
Chemotherapy markedly reduces B cells but not T cells and NK cells in patients with cancer: AbstractChemotherapy is still the backbone of systemic treatment in the majority of cancers. However, immunotherapies, especially those based on checkpoint inhibition, are additional therapy options for many. For this, functional T cells are a mandatory requirement. The aim of this prospective study was to investigate the influence of chemotherapy on the cellular immune status of individual patients. Peripheral...
Multi-Path Tumor Inhibition via the Interactive Effects between a Tumor Microenvironment and an Oxygen Self-Supplying Delivery System for a Photosensitizer: Publication date: Available online 30 December 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Xue Rui, Ye Yang, Jingjing Wu, Jing Chen, Qingqing Chen, Rongrong Ren, Qingqing Zhang, Yingying Hu, Dengke YinAbstractThe tumor microenvironment (TME) affects not only tumor growth and metastasis, but also therapy efficacy. In the present...
Pluronic-based graphene oxide-methylene blue nanocomposite for photodynamic/photothermal combined therapy of cancer cells: Publication date: Available online 30 December 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Min Ma, Lu Cheng, Anyi Zhao, Huilan Zhang, Aiping ZhangAbstractA new nanocomposite containing methylene blue (MB), graphene oxide (GO) and Pluronic F127 (PF127) had been developed for combined photothermal therapy (PTT) and photodynamic therapy (PDT). In this study, GO...
Treatment efficacy of photoactivated disinfection versus <em>Salvadora persica</em> gel in experimental gingivitis: Publication date: Available online 30 December 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Dhaifallah Alshehri, Ali Alqerban, Abdulaziz SamranAbstractBackgroundThis clinical trial aimed to study the comparison of clinical gingival inflammatory scores and levels of pathogenic bacteria with professionally administered plaque removal (PAPR) with photoactivated...
Antimicrobial photodynamic and wound healing activity of curcumin encapsulated in silica nanoparticles: Publication date: Available online 30 December 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Mahtab Mirzahosseinipour, Khatereh Khorsandi, Reza Hosseinzadeh, Mehrgan Ghazaeian, Fedora Khatibi ShahidiAbstractThe multidrug resistance of pathogenic bacteria has become a serious problem to public health. Therefore finding novel approaches to combat multidrug resistant bacteria have...
Evaluating the effectiveness of adjuvant radiotherapy in addition to surgery versus surgery alone at improving oncologic outcomes for early stage buccal carcinoma: a systematic review: AbstractObjectiveTo systematically review the evidence to evaluate oncologic outcomes for patients with early stage buccal squamous cell carcinoma treated with surgery versus surgery and adjuvant radiation therapy.Data sourcesOvid MedLine, EMBASE, Google Scholar, PubMed.Review methodsThe primary purpose was to perform...
Designing expanded bipyridinium as redox and optical probes for DNA: Photochem. Photobiol. Sci., 2020, Accepted ManuscriptDOI: 10.1039/C9PP00418A, PaperEmanuela Trovato, Maria Letizia Di Pietro, Antonino Giannetto, Grégory Dupeyre, Philippe P. Lainé, Francesco Nastasi, Fausto Puntoriero, Sebastiano CampagnaWe report on the light-switch behavior of two head-to-tail expanded bipyridinium species as a function of their interaction with calf thymus DNA and polynucleotides. In particular, both DNA and...
Examining seasonal variation in epistaxis in a maritime climate: AbstractBackgroundEpistaxis is a common reason patients present to the emergency department. There is significant variation in climate across Canada. Our study aimed to determine if epistaxis is related to season, temperature and humidity in a Maritime climate.MethodsEthics approval was obtained. A retrospective chart review was performed. Patients who presented to the Saint John Regional Hospital Emergency Room between July 2015 and...
Mode of action of carboplatin via activating p53/miR‐145 axis in head and neck cancers: ObjectivesIn this study, we aimed at investigating the expressions of miR‐145 and its well‐characterized direct targets on carboplatin treatment.Study DesignLaboratory study.MethodsThe effect of carboplatin and miR‐145 on the proliferative capacity of head and neck squamous cell carcinoma cells was evaluated using Cell Viability Detection Kit‐8. Expressions of miR‐145 and its targets were evaluated using quantitative...
Predicting the Number of Fibular Segments to Reconstruct Mandibular Defects: ObjectivesSeveral classification schemes have been proposed to categorize mandibular defects following surgical resection; however, there is a paucity of data to guide an optimal reconstruction. This study examines the feasibility of using a geometric algorithm to simplify and determine the optimal reconstruction for a given mandibular defect. This algorithm is then applied to three different mandible defect classification...
Reconstructive and prosthodontic outcomes after multiple palatomaxillary reconstructions: ObjectiveA subset of patients who undergo major palatomaxillary reconstruction do not initially achieve their intended oncologic and/or reconstructive goals and require additional surgery. We aim to detail the unique management considerations in this patient population.MethodsWe performed a retrospective review of patients who underwent palatomaxillary reconstruction by the senior author (m.l.u.) between 1998...
Carbon nanotube composite hydrogels for vocal fold tissue engineering: Biocompatibility, rheology, and porosity.: Related ArticlesCarbon nanotube composite hydrogels for vocal fold tissue engineering: Biocompatibility, rheology, and porosity.Mater Sci Eng C Mater Biol Appl. 2019 Oct;103:109861Authors: Ravanbakhsh H, Bao G, Latifi N, Mongeau LGAbstract Porous composite hydrogels were prepared using glycol chitosan as the matrix, glyoxal as the chemical crosslinker, and carbon nanotubes (CNTs)...
Rare cases of head and neck's neuroendocrine carcinomas disease: Case series of 4 patients and review of the literature.: Related ArticlesRare cases of head and neck's neuroendocrine carcinomas disease: Case series of 4 patients and review of the literature.Int J Surg Case Rep. 2019 Dec 13;66:270-276Authors: Bouzbouz A, Abdulhakeem B, Laababsi R, Rouadi S, Abada R, Roubal M, Mahtar MAbstract INTRODUCTION: Primary neuroendocrine carcinomas are uncommon head and neck malignancies. Their classification...
Risk of second primary papillary thyroid cancer among adult cancer survivors in the United States, 2000-2015.: Related ArticlesRisk of second primary papillary thyroid cancer among adult cancer survivors in the United States, 2000-2015.Cancer Epidemiol. 2019 Dec 26;64:101664Authors: Schonfeld SJ, Morton LM, de González AB, Curtis RE, Kitahara CMAbstract BACKGROUND: While radiotherapy is a major risk factor for thyroid cancer after childhood cancer, factors contributing to increased thyroid...
Panel 5: Impact of otitis media on quality of life and development.: Related ArticlesPanel 5: Impact of otitis media on quality of life and development.Int J Pediatr Otorhinolaryngol. 2019 Dec 20;:109837Authors: Homøe P, Heidemann CH, Damoiseaux RA, Lailach S, Lieu JEC, Phillips JS, Venekamp RPAbstract OBJECTIVE: To summarize recent advances in knowledge on otitis media (OM) and quality of life (QoL) and development by synthesizing relevant research in this field published between June 1.,...
Carbon dioxide laser versus cold-steel supraglottoplasty: A comparison of post-operative outcomes.: Related ArticlesCarbon dioxide laser versus cold-steel supraglottoplasty: A comparison of post-operative outcomes.Int J Pediatr Otorhinolaryngol. 2019 Dec 24;130:109843Authors: Yeung JC, Ali SO, McKeon MG, Grenier S, Kawai K, Rahbar R, Watters KFAbstract OBJECTIVE: Supraglottoplasty is the mainstay of surgical treatment for laryngomalacia, and is commonly performed via two methods: cold steel...
Acute pediatric tracheitis: Distinguishing the disease by tracheostomy status.: Related ArticlesAcute pediatric tracheitis: Distinguishing the disease by tracheostomy status.Int J Pediatr Otorhinolaryngol. 2019 Nov 29;130:109800Authors: Ni JS, Kohn J, Shah UK, Levi JRAbstract OBJECTIVES: Tracheitis is an upper airway infection that often presents in patients with tracheostomies and can potentially cause airway obstruction. This study aims to use a nationwide database to identify a large cohort...
Age-related variability in pediatric scalp thickness: Implications for auditory prostheses.: Related ArticlesAge-related variability in pediatric scalp thickness: Implications for auditory prostheses.Int J Pediatr Otorhinolaryngol. 2019 Dec 24;130:109853Authors: Sharma SD, Park E, Purcell PL, Gordon KA, Papsin BC, Cushing SLAbstract OBJECTIVES: Minimizing soft tissue reduction during the placement of percutaneous implants has been encouraged to improve cosmesis and perhaps decrease soft tissue...
Parents' satisfaction with a trial of a newborn hearing screening programme in Jordan.: Related ArticlesParents' satisfaction with a trial of a newborn hearing screening programme in Jordan.Int J Pediatr Otorhinolaryngol. 2019 Dec 24;130:109845Authors: Zaitoun M, Nuseir AAbstract OBJECTIVE: This study examines parents' satisfaction level toward a trial of a newborn hearing screening programme (NHSP) that was applied in King Abdullah II University Hospital (KAUH) in Jordan over one year. This...
Predictive significance of Charcot-Leyden Crystal mRNA levels in nasal brushing for nasal polyp recurrence.: Related ArticlesPredictive significance of Charcot-Leyden Crystal mRNA levels in nasal brushing for nasal polyp recurrence.Rhinology. 2019 Dec 29;:Authors: Qi S, Yan B, Liu C, Wang C, Zhang LAbstract BACKGROUND: Tissue eosinophils have been shown to be associated with polyp recurrence in chronic rhinosinusitis with nasal polyps (CRSwNP). We addressed whether the mRNA levels of Charcot-Leyden...
Endoscopic transnasal orbital decompression for Graves' ophthalmopathy, a systematic review of the literature.: Related ArticlesEndoscopic transnasal orbital decompression for Graves' ophthalmopathy, a systematic review of the literature.Rhinology. 2019 Dec 29;:Authors: Tsetsos N, Daskalakis D, Tzakri D, Blioskas S, Goudakos J, Markou KAbstract BACKGROUND: The aim of this study was to assess all available data regarding the efficacy of endoscopic transnasal orbital decompression for Graves'...
Optimizing DyNaChron instrument for assessing chronic nasal dysfunction symptoms by Rasch analysis.: Related ArticlesOptimizing DyNaChron instrument for assessing chronic nasal dysfunction symptoms by Rasch analysis.Rhinology. 2019 Dec 30;:Authors: Rotonda C, Soudant M, Epstein J, Goetz C, Jankowski R, Guillemin FAbstract BACKGROUND: The DyNaChron (Dysfonctionnement Nasal Chronique) questionnaire is a self-reporting 78-item instrument assessing six symptoms and their consequences of chronic...
Autonomic dysfunction as an independent risk factor for uncontrolled inflammation in chronic rhinosinusitis following functional endoscopic sinus surgery.: Related ArticlesAutonomic dysfunction as an independent risk factor for uncontrolled inflammation in chronic rhinosinusitis following functional endoscopic sinus surgery.Rhinology. 2019 Dec 30;:Authors: Chen WC, Lin WC, Yang CH, Wu CN, Luo SDAbstract BACKGROUND: Chronic rhinosinusitis (CRS) is a multi-factorial disorder that causes systemic...
Modulation of virulence in <em>Enterococcus faecalis</em> cells surviving antimicrobial photodynamic inactivation with reduced graphene oxide-curcumin; an <em>ex vivo</em> biofilm model: Publication date: Available online 30 December 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Roghayeh Ghorbanzadeh, Hadi Assadian, Nasim Chiniforush, Steven Parker, Babak Pourakbari, Babak Ehsani, Mohammad Yousef Alikhani, Abbas BahadorAbstractBackgroundEnterococcus faecalis,...
Mercury increase in Lake Champlain fish: links to fishery dynamics and extreme climatic events: AbstractMercury concentrations in Lake Champlain fish increased (2011–2017) for the first time in more than two decades. The increase, however, was not consistent among species or throughout the lake. Mercury concentrations in smallmouth bass and yellow perch from the three Main Lake segments increased significantly while concentrations in the eastern portions of the lake (Northeast Arm and Malletts Bay)...
Associated Syndromes in patients with Pierre Robin Sequence: Publication date: Available online 30 December 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Peter Karempelis, Mitchell Hagen, Noelle Morrell, Brianne Barnett RobyAbstractObjectivesClassically, Pierre Robin Sequence (PRS) is a triad of micrognathia, glossoptosis, and airway obstruction, although frequently associated with cleft palate. Current literature reports that Stickler syndrome is the most common syndrome...
The Flex robotic system compared to transoral laser microsurgery for the resection of supraglottic carcinomas: first results and preliminary oncologic outcomes: AbstractPurposeTransoral robotic surgery (TORS) has the potential to improve some inherent disadvantages of transoral laser microsurgery (TLM). Here, we retrospectively assessed the application of the Medrobotics Flex system for the resection of supraglottic carcinomas compared to TLM.Methods84 patients underwent surgery for supraglottic...
Correlation Between Microbiological Profiles of Adenoid Tissue and Nasal Discharge in Children with Co-existent Chronic Adenoiditis and Chronic Rhinosinusitis: AbstractChronic adenoiditis leading to adenoid hypertrophy is common in children. Many cases would also have co-existing chronic rhinosinusitis (CRS). Infact, long lasting bacterial infection of the adenoids has been hypothesized to be the cause for CRS in these children. A cross-sectional study was conducted in the departments of ENT and...
Best practices for emergency surgical airway: A systematic review.: Related ArticlesBest practices for emergency surgical airway: A systematic review.Laryngoscope Investig Otolaryngol. 2019 Dec;4(6):602-608Authors: DeVore EK, Redmann A, Howell R, Khosla SAbstract Objective: In the case of an emergency surgical airway, current guidelines state that surgical cricothyrotomy is preferable to tracheotomy. However, complications associated with emergency cricothyrotomy may be more frequent and...
Turkish adaptation of quality of life questionnaire for children with hearing loss and the assesment of the effects of hearing loss on quality of life among children aged 7-12.: Related ArticlesTurkish adaptation of quality of life questionnaire for children with hearing loss and the assesment of the effects of hearing loss on quality of life among children aged 7-12.Int J Pediatr Otorhinolaryngol. 2019 Dec 12;130:109813Authors: Nemli N, Bayramoğlu İ, Kemal Kemaloğlu YAbstract Monitoring...
The Association of Serum Eosinophilia with Structured Histopathology in Chronic Rhinosinusitis.: Related ArticlesThe Association of Serum Eosinophilia with Structured Histopathology in Chronic Rhinosinusitis.Ann Otol Rhinol Laryngol. 2019 Dec 30;:3489419898200Authors: Ganti A, Kuhar HN, Eggerstedt M, Mahdavinia M, Gattuso P, Batra PS, Tajudeen BAAbstract BACKGROUND: Prior studies have demonstrated associations between serum eosinophilia and chronic rhinosinusitis (CRS) pathogenesis. However,...
Effect of Unilateral Cordotomy on Perception of Dysphagia.: Related ArticlesEffect of Unilateral Cordotomy on Perception of Dysphagia.Ann Otol Rhinol Laryngol. 2019 Dec 30;:3489419898711Authors: Conklin M, Clary MS, Cuadrado EM, Jetté MEAbstract OBJECTIVES: CO2 laser medial transverse cordotomy is a permanent static procedure performed to achieve adequate functional airway in cases of posterior glottic stenosis and bilateral vocal fold paralysis. Although it is the preferred method to manage...
Dual Coaptation of Facial Nerve Using Masseteric Branch of Trigeminal Nerve for Iatrogenic Facial Palsy: Preliminary Reports.: Related ArticlesDual Coaptation of Facial Nerve Using Masseteric Branch of Trigeminal Nerve for Iatrogenic Facial Palsy: Preliminary Reports.Ann Otol Rhinol Laryngol. 2019 Dec 30;:3489419893722Authors: Lee YS, Ahn JH, Park HJ, Lee HJ, Bae MR, Roh JL, Choi SH, Nam SY, Kim SYAbstract OBJECTIVES: Immediate facial nerve substitution or graft technique has been used for...
Superior mediastinal lymphadenopathy by silicosis mimicking metastasis of papillary thyroid carcinoma – Case report and literature review: Publication date: Available online 31 December 2019Source: Auris Nasus LarynxAuthor(s): Toshiaki Tsukatani, Hideki Niwa, Takeshi Komori, Tatsuya Yoneyama, Hiroyuki Tsuji, Takatoshi Michigishi, Kunihiko Yokoyama, Tomokazu YoshizakiAbstractSilicosis is caused by inhalation of silica dust and is the most common type of pneumoconiosis. The characteristics of silicosis...
Similar immune mechanisms control experimental airway eosinophilia elicited by different allergens and treatment protocols.: Related ArticlesSimilar immune mechanisms control experimental airway eosinophilia elicited by different allergens and treatment protocols.BMC Immunol. 2019 06 04;20(1):18Authors: Hyde EJ, Wakelin KA, Daniels NJ, Ghosh S, Ronchese FAbstract BACKGROUND: Mouse models have been extremely valuable in identifying the fundamental mechanisms of airway inflammation that underlie...
The clinical significance and potential molecular mechanism of integrin subunit beta 4 in laryngeal squamous cell carcinoma.: Related ArticlesThe clinical significance and potential molecular mechanism of integrin subunit beta 4 in laryngeal squamous cell carcinoma.Pathol Res Pract. 2019 Dec 16;:152785Authors: Zhong F, Lu HP, Chen G, Dang YW, Li GS, Chen XY, Qin YY, Yao YX, Zhang XG, Liang Y, Li MX, Mo M, Zhang KL, Ding H, Huang ZG, Wei ZXAbstract The relationship between integrin beta 4...
Development of an Acoustic Simulation Method during Phonation of the Japanese Vowel /a/ by the Boundary Element Method.: Related ArticlesDevelopment of an Acoustic Simulation Method during Phonation of the Japanese Vowel /a/ by the Boundary Element Method.J Voice. 2019 Dec 27;:Authors: Shiraishi M, Mishima K, Umeda HAbstract OBJECTIVES: The purpose of the present study was to establish the method for an acoustic simulation of a vocal tract created from CT data during phonation of the Japanese...
Characteristics of the Voice of Dysphonic School Children from 4:0 to 7:11 Years Old.: Related ArticlesCharacteristics of the Voice of Dysphonic School Children from 4:0 to 7:11 Years Old.J Voice. 2019 Dec 27;:Authors: Hoffmann CF, Cielo CAAbstract BACKGROUND: Childhood dysphonia is frequent and has many origins, with the most common initial symptom being the altered vocal quality. OBJECTIVE: Describe and correlate the auditory-perceptual and acoustic characteristics of the voice,...
Anatomical Study of Two Cricothyroid Approaches to the Cadaver Larynx.: Related ArticlesAnatomical Study of Two Cricothyroid Approaches to the Cadaver Larynx.J Voice. 2019 Dec 27;:Authors: Panossian H, Pasick LJ, Sataloff RTAbstract OBJECTIVE: The purpose of this study was to measure the angle and depth at which the vocal folds are accessed via transcutaneous injection through two different approaches through the cricothyroid membrane. METHODS: Twenty-five cadavers preserved with formalin...
[TREATMENT AND PREVENTION OF METASTASIS TO THE PRE- AND PARATRACHEAL LYMPH NODES IN CANCER OF THE LARYNX WITH SPREAD TO THE SUBGLOTTIC SECTION].: Related Articles[TREATMENT AND PREVENTION OF METASTASIS TO THE PRE- AND PARATRACHEAL LYMPH NODES IN CANCER OF THE LARYNX WITH SPREAD TO THE SUBGLOTTIC SECTION].Georgian Med News. 2019 Nov;(296):12-15Authors: Dabrundashvili Z, Bakhtadze L, Bakhturidze D, Dabrundashvili NAbstract Based on the specificity of the subglottic cancer, the basic method...
Evaluation of the effect of Boyle-Davis mouth gag on intracranial pressure in patients undergoing adenotonsillectomy by using ultrasonographic optic nerve sheath diameter measurement: Publication date: Available online 31 December 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Elif Karali, Abdullah Demirhan, Akif Günes, Ahmet UralABSTRACTObjectiveWe aimed to evaluate the effect of an increase in intracranial pressure (ICP) due to sympatho-adrenergic response caused by...
Pediatric Vocal Symptoms Questionnaire (PVSQ): four new versions for parental evaluation and self-evaluation: Publication date: Available online 31 December 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Livia Lima, Mara BehlauAbstractObjectivesTo elaborate reduced versions of the Pediatric Vocal Symptoms Questionnaire (PVSQ) protocol for the two forms of application of the instrument: self-evaluation (SE) and parental evaluation (PE).MethodsThe Brazilian validation...
Cross-cultural Adaptation and Psychometric Assessment of a Persian Version of Proctor's Developmental Vocal Assessment Protocol: Description of Persian Infant Vocal Development: Publication date: Available online 31 December 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Masoomeh Salmani, Reyhaneh Noruzi, Raheb Ghorbani, Majid Mirmohammadkhani, Maliheh Rafiyi, Bahareh Mansoori, Mona Simin GhalamAbstractObjectivesWith increasing recognition of the importance of pre-linguistic...
Our Uncommon Experience with 6 Cases of Riedel's Thyroiditis (Woody Thyroiditis): AbstractRiedel's thyroiditis is a rare form of thyroiditis. Estimated prevalence is 1.06/100,000 population and is reported in 0.05% of thyroidectomy specimens. It has 38% association with systemic fibrotic conditions. We retrospectively reviewed 6 cases of Riedel's thyroiditis at a tertiary care centre in south India, from 2011 through 2019 with special emphasis on demography, clinical presentation, workup, management,...
Tumor targeting vitamin B12 derivatives for X-ray induced treatment of pancreatic adenocarcinoma: Publication date: Available online 31 December 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Liberty N. Gendron, Dillon C. Zites, Ethan P.M. LaRochelle, Jason R. Gunn, Brian W. Pogue, Thomas A. Shell, Jennifer R. ShellAbstractBackgroundX-Ray induced phototherapy is highly sought after as it provides a deep tissue, synergistic method of treating cancers via standard-of-care radiotherapy....
Curcumin induced photodynamic therapy mediated suppression of quorum sensing pathway of <em>Pseudomonas aeruginosa</em>: An approach to inhibit biofilm <em>in vitro</em>: Publication date: Available online 31 December 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Hayder Abdulrahman, Lama Misba, Shabbir Ahmad, Asad U. KhanAbstractObjectiveThe objective of this study was to inhibit thePseudomonas aeruginosa biofilm through curcumin-mediated antimicrobial photodynamic...
Apoptosis signaling molecules as treatment targets in head and neck squamous cell carcinoma: ObjectivesTo evaluate BCL‐2 family signaling molecules in head and neck squamous cell carcinoma (HNSCC) and examine the ability of therapeutic agents with variable mechanisms of action to induce apoptosis in HNSCC cells.Methodsmessenger ribonculeic acid (mRNA) expression of BAK, BAX, B‐cell lymphoma (Bcl‐2), BCL2 Like 1 (BCL2L1), and MCL1 were measured in The Cancer Genome Atlas (TCGA) head and neck cancer...
Serum Neurofilament Light Predicts Severity and Prognosis in Patients with Ischemic Stroke: AbstractSerum neurofilaments are markers of axonal injury. We investigated whether serum neurofilament light (sNfL) is a potential prognostic marker of functional outcome in Chinese patients with acute ischemic stroke (AIS). From May 2015 to December 2018, consecutive patients with AIS from the Department of Neurology of the Second Hospital of Jilin University were included. sNfL concentration was tested at...
The Flex robotic system compared to transoral laser microsurgery for the resection of supraglottic carcinomas: first results and preliminary oncologic outcomes.: Related ArticlesThe Flex robotic system compared to transoral laser microsurgery for the resection of supraglottic carcinomas: first results and preliminary oncologic outcomes.Eur Arch Otorhinolaryngol. 2020 Jan 01;:Authors: Hussain T, Lang S, Haßkamp P, Holtmann L, Höing B, Mattheis SAbstract PURPOSE: Transoral robotic surgery (TORS)...
Preoperative prediction of non-invasive follicular thyroid neoplasm with papillary-like nuclear features: a Canadian single-Centre experience: AbstractBackgroundAn international group of experts recommended reclassifying non-invasive follicular variant of papillary thyroid cancers (FVPTC) as 'non-invasive follicular thyroid neoplasm with papillary-like nuclear features' (NIFTP) in April 2016. The purpose of this study was to establish preoperative clinical, laboratory, ultrasonographic, and cytological...
Safety of Intralesional Cidofovir for Adjuvant Treatment of Recurrent Respiratory Papillomatosis: This case series examines the safety of adjuvant intralesional cidofovir injections in patients with recurrent respiratory papillomatosis.Original InvestigationJanuary 2, 2020Evaluation of Safety of Intralesional Cidofovir for Adjuvant Treatment of Recurrent Respiratory PapillomatosisRebecca C. Hoesli, MD1; Aaron L. Thatcher, MD2; Norman D. Hogikyan, MD2; et alRobbi A. Kupfer, MD2Author Affiliations1Bastian...
Mantle Cell Lymphoma Involving Major and Minor Salivary Glands With Parotid Sparing: This case report describes a man in his 70s who presented with painless bilateral neck swelling of 1 year's duration that had gradually grown to affect his speech, and was diagnosed with mantle cell lymphoma.
Diffuse Palatal Swelling: A healthy woman in her 60s was referred for evaluation of a palatal swelling of unknown duration. She denied any pain or discomfort from the site and stated that the increasing size of the mass was what first alerted her to its presence. What is your diagnosis?The extraoral examination results were within normal limits, with no evidence of swelling, expansion, trismus, or lymphadenopathy. Intraoral examination revealed a focally ulcerated, fluctuant 2.5 × 2 × 1-cm pink-red...
Prescribing Time to Temporize Burnout: Burnout is harming our medical students, residents, fellows, and colleagues. What is at stake is not only our professional well-being but also the safety of our patients. A 1-point increase in a surgeon's self-reported emotional exhaustion score is associated with a 5-point increase in errors; this negative association is doubled for a 1-point increase in depersonalization scores. Burnout exacts a staggering toll in safety and quality of care, lost productivity,...
Dyna-CT of the temporal bone for case-specific three-dimensional rendering of the stapedial muscle for planning of electrically evoked stapedius reflex threshold determination during cochlear implantation directly from the stapedius muscle via a retrofacial approach: a pilot study: AbstractPurposeEvaluation of 3D Dyna-CTs to improve cochlear implantation (CI) planning and intraoperative electrically elicited stapedius reflex threshold (ESRT) measurements.MethodsA prospective observational cohort...
Deossification of the Otic Bone in High Pressure CSF Otorhinorrhea: A New Radiological Finding: AbstractTo highlight a new radiological feature in a patient with labyrinthine malformation presenting with bilateral spontaneous high pressure cerebrospinal fluid (CSF) otorhinorrhea. Study design—retrospective case review. Setting—academic, tertiary cochlear implant center. A cochlear implantee with Incomplete Partition Defect (Type 1) presented with meningitis and CSF otorhinorrhea for which she initially...
Frontal sinus fractures and cerebrospinal fluid leaks: a change in surgical paradigm: Purpose of review Traditionally, frontal sinus trauma has been treated using open incisions to access the anterior and/or posterior table. Mounting evidence indicates frontal sinus trauma can be managed using an endoscopic endonasal approach (EEA) with less morbidity. Such an approach permits preservation of a functional sinus and less reliance on computed tomography for postoperative follow up. The goal of this...
Updates on current evidence for biologics in chronic rhinosinusitis: Purpose of review The purpose of this review is to present the most important recent developments concerning biologics as a therapeutic option for chronic rhinosinusitis (CRS).Recent findings mAb anti-IL-4 receptor α (Dupilumab) was recently approved by Food and Drug Administration (FDA) for patients with CRSwNP and four other biologics are under investigation, with promising preliminary results.Summary CRS is a disease associated...
What is the evidence for fluticasone exhalation delivery system in chronic rhinosinusitis?: Purpose for review The aim of this article is to review the current literature regarding a novel method of topically delivering nasal steroids, namely exhalation delivery system-fluticasone (EDS-FLU), for the treatment of chronic rhinosinusitis (CRS).Recent findings Recent Food and Drug Administration approval of EDS-FLU and increasing evidence surrounding its efficacy and safety has led to an additional tool...
Latest developments on topical therapies in chronic rhinosinusitis: Purpose of review Topical therapies play an important role in the management of chronic rhinosinusitis (CRS). A detailed literature review was undertaken to appraise recent evidence surrounding current topical therapies and novel treatments used in the setting of recalcitrant CRS.Recent findings Effective sinus surgery aids in the delivery of topical therapies. Budesonide nasal rinses delivered by saline irrigation offer clinical...
Update on long-term outcomes for chronic rhinosinusitis in cystic fibrosis: Purpose of review This article reviews the existing body of literature regarding long-term outcomes of various treatments for chronic rhinosinusitis (CRS) in the cystic fibrosis population.Recent findings The management of CRS in cystic fibrosis involves a multitude of medical and surgical therapies. Despite their high usage amongst clinicians, corticosteroids and antibiotics currently have little outcome data supporting...
What is the evidence for macrolide therapy in chronic rhinosinusitis?: Purpose of review To assess the most recent evidence for macrolide therapy in chronic rhinosinusitis (CRS).Recent findings Macrolides play a significant role in a select group of patients with CRS. Low-serum and tissue eosinophilia in patients who do not respond to corticosteroid therapy appeared to be an effective predictor of a CRS phenotype suitable for a trial of long-term macrolide therapy. Therapies using half a dose for...
The relationship of chronic rhinosinusitis and depression: Purpose of review The aim of this article is to identify and describe the relationship between chronic rhinosinusitis (CRS) and comorbid depression, including the patient factors that may increase the risk of depression. The impact of comorbid depression on quality of life, response to treatment and healthcare utilization will also be assessed.Recent findings CRS is associated with a significantly increased prevalence of depression, where...
Indications for Eustachian tube dilation: Purpose of review Eustachian tube dilation is a controversial surgical procedure because the intended problem for which it is meant to address, obstructive Eustachian tube dysfunction, is a clinical diagnosis without a reliable diagnostic tool to test.In the past 10 years, balloon dilation Eustachian tuboplasty (BDET) has been the most commonly performed Eustachian tube dilation procedure. The present review seeks to identify the patients who may benefit...
Original ArticlePublished: 01 January 2020Our Uncommon Experience with 6 Cases of Riedel's Thyroiditis (Woody Thyroiditis)Dhalapathy Sadacharan, Althaf Ahmed, S. Smitha, Shriraam Mahadevan, R. Vimala & Hemchand PrasadIndian Journal of Otolaryngology and Head & Neck Surgery (2020)Cite this articleAbstractRiedel's thyroiditis is a rare form of thyroiditis. Estimated prevalence is 1.06/100,000 population and is reported in 0.05% of thyroidectomy specimens. It has 38% association with systemic...
Correlation Between Microbiological Profiles of Adenoid Tissue and Nasal Discharge in Children with Co-existent Chronic Adenoiditis and Chronic Rhinosinusitis: AbstractChronic adenoiditis leading to adenoid hypertrophy is common in children. Many cases would also have co-existing chronic rhinosinusitis (CRS). Infact, long lasting bacterial infection of the adenoids has been hypothesized to be the cause for CRS in these children. A cross-sectional study was conducted in the departments of ENT and...
Mucoepidermoid Carcinoma of the Salivary Gland: Long Term Outcomes from a Tertiary Cancer Center in India: AbstractTo analyze the patterns of failure and factors affecting recurrence and overall survival in mucoepidermoid carcinoma of the salivary gland. The hospital records were retrospectively analyzed from October 2010 to January 2016. Patients diagnosed as mucoepidermoid carcinoma of the salivary gland were eligible for analysis. All patients received surgery as the primary treatment modality...
Comparitive Study on Impact of Dry (Rigid) Versus Wet (Soft) Graft on the Outcome of Type 1 Tympanoplasty: AbstractTo analyse the rate of success of dry versus wet temporalis fascia graft in type 1 tympanoplasty. A prospective, randomised study was conducted. One hundred adult patients (males and females) with chronic suppurative otitis media (mucosal type) were divided into 2 groups of 50 each: one group underwent dry temporalis fascia graft tympanoplasty and the other underwent wet temporalis fascia...
Original ArticlePublished: 02 January 2020Outcome of Treatment in Verrucous Carcinoma of Oral Cavity: A Tertiary Rural Hospital ExperienceKouser Mohammadi, S. M. Azeem Mohiyuddin, N. Harshitha, T. N. Suresh, C. S. B. R. Prasad, A. Sagayaraj, Ravindra P. Deo, K. S. Gopinath, G. N. Manjunath, A. Prashanth Babu, Pradeep Krishna, K. Abhilasha, H. S. Brindha, D. Aishwarya Raj Pillai & Arjun GuptaIndian Journal of Otolaryngology and Head & Neck Surgery (2020)Cite this articleAbstractVerrucous carcinoma...
Indian Journal of Otolaryngology and Head & Neck Surgerypp 1–5| Cite asIn Ear Surgeries Intravenous Dexamethasone Preoperatively Decreases Post Operative Sore Throat After Endotracheal Intubation in Adult Patients: A Prospective Randomized Control StudyAuthorsAuthors and affiliationsGurchand SinghAnisha PuriEmail author1.2.Original ArticleFirst Online: 02 January 2020AbstractSore throat is commonly seen after general anaesthesia with endotracheal intubation. It is distressing for the patient...
Clinical ReportPublished: 02 January 2020Deossification of the Otic Bone in High Pressure CSF Otorhinorrhea: A New Radiological FindingSanjay Vaid, Neelam Vaid & Avvaru Satya KiranIndian Journal of Otolaryngology and Head & Neck Surgery (2020)Cite this articleAbstractTo highlight a new radiological feature in a patient with labyrinthine malformation presenting with bilateral spontaneous high pressure cerebrospinal fluid (CSF) otorhinorrhea. Study design—retrospective case review. Setting—academic,...
European Archives of Oto-Rhino-Laryngologypp 1–11| Cite asRedefining adequate margins in oral squamous cell carcinoma: outcomes from close and positive marginsAuthorsAuthors and affiliationsPrateek V. JainRajeev SharanKapila ManikantanGary M. ClarkSanjoy ChatterjeeIndranil MallickParomita RoyPattatheyil Arun1.2.3.4.Head and NeckFirst Online: 02 January 2020AbstractPurposeAdequacy of surgical margins impacts outcomes in oral cancer. We sought to determine whether close and positive margins have different...
Dyna-CT of the temporal bone for case-specific three-dimensional rendering of the stapedial muscle for planning of electrically evoked stapedius reflex threshold determination during cochlear implantation directly from the stapedius muscle via a retrofacial approach: a pilot study: ConclusionsThe use of Dyna-CT and 3D rendering is a helpful tool for preoperative planning of cochlear implantations and ESRT measurements from the stapedius muscle via the retrofacial approach. (Source: European Archives...
GATA1-regulated JAG1 promotes ovarian cancer progression by activating Notch signal pathway: AbstractOvarian cancer is the major cause of mortality due to late stage diagnoses and lower survival rates, and the mechanism of cancer progression is not completely understood. Thus, exploring the regulatory factors of ovarian cancer proliferation and metastasis is urgent. JAG1 expression in KOV3 and OVCA433 cells was detected by qPCR and western blot. MTT and Transwell assays were used to determine cell...
Our Experience with Intraoral Submandibular Gland Excision: AbstractThe aim of this paper is to present our experience with intraoral approach for submandibular gland excision in terms of effectiveness and safety in patients with chronic sialadenitis. This is a prospective study carried out from November, 2016 to April, 2018 analyzing 13 patients of chronic sialadenitis. The indication of intraoral approach was either failed attempt to remove the stone endoscopically, chronic sialadenitis or benign...
Atypical Facial Chondroid Syringoma, A Rare Clinical Entity: Case Report with Review of Literature: AbstractChondroid syringoma (CS) is a rare mixed tumor of sweat gland origin with a reported incidence of less than 0.1%. The tumor is mostly benign and usually seen in males. It comprises of both epithelial and mesenchymal elements. The usual presentation and clinical course of this condition makes it liable to be confused with other commoner skin conditions. We hereby present a case of facial CS...
When size does not matter: a rare case of popliteal artery aneurysm presenting with foot drop and its endovascular management: AbstractPopliteal artery aneurysms (PAA) are the commonest arterial aneurysm of the periphery. It is defined as focal dilation more than 50% of the normal vessel diameter, which usually varies between 7 and 11 mm. The most common presentation for PAA is claudication due to luminal stenosis caused by mural thrombus or acute limb ischaemia due to thromboembolism. It is much...
Congenital right diaphragmatic hernia in an adult: AbstractDiaphragmatic hernia in the absence of trauma in adults is very rare. It occurs as a result of unilateral diaphragmatic agenesis. The diagnosis of this rare condition is typically made in early infancy. However, in asymptomatic patients, the diagnosis is often delayed for months and even years. We present a case of a 27-year-old female, who was referred 48-hours after Caesarean section with suspected pulmonary embolism. Computed tomography...
Palliative fenestration for a symptomatic subcarinal bronchogenic cyst by the prone position approach: AbstractA complete excision is the most reliable therapy for bronchogenic cysts (BC) but is often accompanied by technical difficulties due to severe adhesions. An 83-year-old-woman with poorly controlled diabetes noted worsening upper abdominal pain after meals and paroxysmal atrial fibrillation. Magnetic resonance imaging revealed a cystic mass in the subcarinal region, and she underwent a thoracoscopic...
Depressed forehead scar: a case report and review of literature: AbstractDepressed forehead scars are not frequently reported in the literature in the West African sub-region. Although they are not commonly reported, few cases were managed and are to be documented. We had seen a case of depressed forehead scar which was due to post frontal avulsion injury of the forehead with an intact posterior table of the frontal bone. He complained of aesthetic and psychological problems of the scar on presentation....
Pseudo-Wellens syndrome, acute pancreatitis, and an anomalous coronary artery: a case report: Chest pain associated with transient electrocardiogram changes mimicking an acute myocardial infarction have been described in acute pancreatitis. AbstractBackgroundChest pain associated with transient electrocardiogram changes mimicking an acute myocardial infarction have been described in acute pancreatitis. These ischemic electrocardiogram changes can present a diagnostic dilemma, especially when patients...
Adrenocortical carcinoma: an ominous cause of hirsutism: Hirsutism is a common medical presentation to family physicians, internists and endocrinologists. Although the cause is commonly benign, a more serious or life-threatening one should not be missed. Here we report a 58-year-old woman, assessed for hirsutism and 15-pound weight gain, with associated easy bruising and mood swings. On physical examination, she was hypertensive with central obesity. Laboratory work was significant for erythrocytosis,...
Chylothorax as a complication of extensive spontaneous left arm DVT: We present a case of right sided chylothorax in the setting of cirrhosis believed to be secondary to extensive venous thromboembolism of the left upper extremity and exacerbated by chylous ascites. Our patient responded to conservative management with anticoagulation and a repeat thoracentesis revealed transformation of the fluid back to straw coloured transudate. We also include a brief discussion of the diagnosis and management...
Treatment of an Adult Skeletal Class III Patient with Surgically Assisted Rapid Palatal Expansion and Facemask: This case report presents the treatment of a 21-year-old male patient with class III skeletal malocclusion, an open bite, and vertical growth pattern. He was managed with surgically assisted rapid palatal expansion (SARPE) along with an orthopedic facemask. The duration of treatment was 16 months. Significant improvement and favourable outcome were observed concerning both facial appearance...
The central role of CT coronary angiography in postcardiac arrest care in the young adult: A 32-year-old man with no medical history went into ventricular fibrillation while running at the gym. He was transferred to our tertiary centre post successful resuscitation where admission electrocardiography and echocardiography were unremarkable. The initial cause of cardiac arrest was suspected arrhythmogenic and he was admitted for further investigations including exercise testing, ajmaline challenge,...
Intracranial pellet embolization: an endovascular endeavor: A 44-year-old man was referred to the neurointerventionalist 6 hours after sustaining a shotgun wound to the left chest, shoulder, and neck from 4 feet away. Physical examination of the chest showed a 5 cm x 5 cm gunshot entry wound on the anterior-superior aspect of the chest involving the supraclavicular and infraclavicular region, with multiple gunshot pellet entry sites riddled in the surrounding vicinity. The patient was taken for a...
Treatment of Miller Class I Gingival Recession with Using Nonpedicle Adipose Tissue after Bichectomy Surgical Technique: A Case Report: Gingival recession is an oral health problem that affects a large part of the population. Several treatments are suggested in the current literature; among them is the use of buccal fat pad grafting. The objective of this case report is to describe the treatment of a Miller Class I gingival recession using a nonpedicled buccal fat pad graft immediately after performing...
Intracranial vessel occlusion preceding the development of mycotic aneurysms in patients with endocarditis: Mycotic aneurysms (MA) are an uncommon complication of infectious endocarditis. Septic emboli are thought to be the precipitating event in their development, but the evidence for this is sparse. We present three cases in which septic embolic occlusion preceded MA development at the occlusion site, suggesting that documented angiographic emboli in patients with infectious endocarditis and bacteremia...
Reno-duodenal fistula as a complication of longstanding renal tract calculus: AbstractWe present a rare case detailing the investigations and subsequent treatment of a lady who presented with a reno-duodenal fistula and perinephric abscess as a complication of staghorn calculus and recurrent upper urinary tract infections. Treatment involved antibiotics, nephrostomy, endoscopic closure of the fistula tract with clips, radiological drain insertion and, ultimately, nephrectomy with primary omental...
Smart watch-detected tachycardia: a case of atrial flutter: AbstractThe use of smart watches like the Apple watch and other wearable electronic devices by the general public has been increasing dramatically. Until their accuracy for detecting dysrhythmias has been well-established, however, it would not be appropriate to rely on them solely to rule-in or rule-out pathology. Nonetheless, unusual findings from these devices should be followed up with more conventional investigations, and this approach...
Alveolar soft part sarcoma mimics prostate cancer metastasis: AbstractA 61-year-old man presented to the oncology clinic with Gleason 9 (4 + 5) prostate cancer. Staging CT showed multiple nodules in both lungs. Since the lung lesions were too small for biopsy, he was started on anti-androgen therapy for suspected metastatic, hormone-sensitive prostate cancer. While his prostate-specific antigen decreased from 32 to <0.1 ng/ml, the multiple lung lesions showed no response on subsequent imaging....
Undescended retropharyngeal parathyroid adenoma with adjacent thymic tissue in a 13-year-old boy with primary hyperparathyroidism: ABSTRACTWe describe a rare presentation of a symptomatic parathyroid adenoma located in an ectopic retropharyngeal position in a 13-year-old boy. Preoperative CT scan and MRI demonstrated the ectopic location of the parathyroid adenoma. The patient underwent successful parathyroidectomy with cure of his hyperparathyroidism. On pathologic exam, the specimen was made up...
Linear dermatomyofibroma over the nape of neck: a report of an unusual case and literature review: AbstractDermatomyofibroma is a rare cutaneous mesenchymal tumor of benign fibroblastic and myofibroblastic derivations. It predominantly affects young women, and it usually presents as a reddish-brown plaque or nodule, which is commonly located over the upper trunk. We report the case of a 41-year-old female patient who presented with progressive linear dermatomyofibroma over the nape of her neck. This...
One dose of immunotherapy leading to an exceptional and durable response in a patient with metastatic renal cell carcinoma: ABSTRACTA 72-year-old man with metastatic clear cell renal carcinoma, who had progressed after previous treatment with Sunitinib and Axitinib, was given one dose of immunotherapy. He was initially unwell after treatment with fever, shortness of breath, chest pain and raised inflammatory markers. Following this he elected not to have any further immunotherapy. Before the treatment...

An atypical manifestation of lateral medullary syndrome: ABSTRACTLateral medullary syndrome is a common brainstem stroke associated with a classical triad of Horner's Syndrome, ipsilateral ataxia and hypalgesia and thermoanasthesia of ipsilateral face. We report a case of a 49-year-old diabetic, non-hypertensive, postmenopausal female who presented with symptoms involving the left dorsal medulla along with right sided hemiparesis and left UMN-type facial palsy. Contralateral hemiparesis was explained...
Insufficient initial treatment but good recovery after diagnosis of pulmonary actinomycosis: AbstractActinomycosis is an infrequent invasive bacterial disease. Although multiple different clinical features of actinomycosis have been described, pulmonary actinomycosis (PA) is a rare but challenging diagnosis and complete cure to make. Here we report the case of a 41-year-old Asian woman who had a mass-like consolidation in the right middle lung field. The lung lesion was exacerbated after initial...
Masquerading dacryocystitis: AbstractIntravascular papillary endothelial hyperplasia (IPEH), otherwise known as Masson's tumor, is a benign lesion of the skin with no known malignant transformations reported. It is considered a non-neoplastic lesion, as it is reactive to some vascular insult, usually a thrombus in a vein leading to vascular endothelial cell proliferation. Masson's tumor typically presents as a slow-growing, indolent lesion commonly affecting the head, neck and arms with a female...
Wearable devices: monitoring the future?: Wearable devices are becoming increasingly utilized in our contemporary world, and the Apple Watch is a popular tool for monitoring the heart rate and more recently, heart rhythm. The Apple Watch Series 4 was the first one granted clearance by the Food and Drug Administration (FDA), allowing rhythm detection and identification of Atrial Fibrillation (AF), on 11 September 2018; outlying however that the definitive diagnosis should not be made before a doctor...
Dagger sign of ankylosing spondylitis:A 40-year-old male presented with inflammatory low back pain from the past 24 years. The pain was mild and intermittent, which improved after taking non-steroidal anti-inflammatory drugs (NSAIDs). From the past 10 years, he experienced increased pain and stiffness in the neck with progressive restriction in neck movement. In addition, two episodes of unilateral acute anterior uveitis were documented last year, which were resolved after topical treatment. He had...
A case report of a rare omental extramedullary hematopoiesis in an adult: 'an idiopathic finding': AbstractThis is a case of a 62-year-old female, known to have multiple medical problems, who presented to her primary care physician with an intermittent abdominal pain and discomfort for a few months. The initial work-up showed mild leucocytosis and a small mass in the omentum. Given that the most concerning differential diagnosis was malignancy, the patient was referred to oncology, where biopsy of...
Primary Myiasis in Surgical Wound of Mandible Symphisis Fracture: A 42 year old patient was referred to the Department of Oral and Maxillofacial Surgery of the Federal University of Uberlândia, for treatment of mandibular fractures (condyles and symphysis), a victim of a run over. The symphysis was surgically approached, using as surgical access the pre-existing laceration in the submental region. Five days after discharge, the patient returned with dehiscence of the wound and physical examination...

Postoperative cardiogenic shock secondary to Takotsubos syndrome: Takotsubo's syndrome is a rare acute reversible heart failure, where the pathophysiology is not fully understood. It is being increasingly diagnosed in varied clinical contexts, which can result in atypical presentations in the context of surgical or anaesthetic stress. We discuss the case of a 22-year-old woman who developed cardiogenic shock and impaired left ventricular function after an elective gynaecological procedure. She had...
Ranolazine Induced Bradycardia, Renal Failure, and Hyperkalemia: A BRASH Syndrome Variant: Ranolazine is a well-known antianginal drug, that was first licensed for use in the United States in 2006. It was objectively shown to improve exercise capacity and to lengthen the time to symptom onset in patients with coronary artery disease. The most commonly reported side effects of ranolazine include dizziness, headache, constipation, and nausea. Here, we describe a case of bradycardia, hyperkalemia, and...
Infective myositis, an uncommon presentation of melioidosis: a case report and review of the literature: AbstractBackgroundMelioidosis is considered endemic in certain areas of the world. Musculoskeletal and soft tissue involvement are relatively uncommon presentations in melioidosis. We present a case of infective myositis in a patient with melioidosis in Sri Lanka, which is not considered an endemic country. Even though multiple cases of melioidosis have been reported with an increasing number...
Laceration of the transverse mesocolon in an old man with a habit of abdominal massage for constipation: a case report: AbstractBackgroundAbdominal massage for the resolution of constipation has been reported to be safe and recommended in some studies. It is conventionally performed for the elderly suffering from intractable constipation. Meantime, isolated mesenteric injury after blunt abdominal trauma is uncommon. Here, we report a case of isolated mesenteric injury following self-abdominal massage...
Inguinal hernia with complete urinary bladder herniation: a case report and review of the literature: AbstractAlthough inguinal hernias are common, inguinal herniation of the urinary bladder wall is rare. Moreover, the complete migration of the urinary bladder into the scrotum is considered less frequent. The majority of patients with bladder hernias are asymptomatic and diagnosis is made intraoperatively; however, difficulties in urination may lead to the correct diagnosis. We report about a case...
Neuromyelitis optica spectrum disorder and active tuberculosis: Tuberculosis is on the rise again. It brings with it potential for neurological involvement both as a direct infection and as a parainfectious process. Accordingly we report the development of neurological problems affecting a 48-year-old patient's vision and sensation while being treated for active tuberculosis. At its nadir her vision deteriorated to nil perception of light and she had a sensory level to T10. Neuromyelitis optica spectrum...
Diffuse large B-cell lymphoma of the vagina in pregnancy: A 28-year-old primigravida was evaluated for complaints of difficulty urinating and pelvic pain of 6-weeks duration. She denied fever, night sweats, weight loss or fatigue. Pelvic ultrasonography revealed a single fetal pole with cardiac activity and a 7 cm mass in the anterior vagina which encased the urethra. The diagnosis of diffuse large B-cell lymphoma germinal centre type was made on analysis of biopsied pelvic mass. Whole body MRI revealed...
Adies tonic pupil presenting with unilateral photophobia successfully treated with dilute pilocarpine: A 40-year-old healthy man presented with a 4-month history of photophobia, blurred vision and a right dilated pupil. Examination revealed a right pupil that was not reactive to light but constricted strongly to a near target and slowly redilated when he looked back in the distance. Pharmacological testing with dilute pilocarpine 0.1% resulted in constriction of the right pupil but no change in the...
When multimodality cardiac imaging saves the day: rare cause of embolic strokes: Hypereosinophilic syndrome (HES) is a rare disorder characterised by eosinophilic infiltration of tissues. Myocardial infiltration occurs in 50%–60% of HES and leads to a condition called Loeffler's endocarditis. This can lead to endomyocardial injury with resultant superimposed thrombus formation and embolic stroke. We describe the case of a 57-year-old female patient presenting with neurological symptoms who was found...
Double-hit monomorphic B-cell lymphoma after liver transplantation: We report the first case of double-hit (MYC and BCL-6) monomorphic post-transplant lymphoproliferative disorder in a patient status post liver transplantation. Our patient is a 71-year-old man with a past medical history of Budd–Chiari syndrome complicated by cirrhosis and hepatocellular carcinoma. He underwent a deceased donor liver transplantation 2 years prior to presentation and was maintained on tacrolimus and mycophenolate...
Subcutaneous sacrococcygeal myxopapillary ependymoma misdiagnosed as pilonidal disease: Ependymomas are neoplasms which arise from the radial glial cells, which many recent studies have proposed are neural stem cells. Extracranial ependymomas are rare. We present the case report and supporting multimedia of a 37-year-old man who presented with a painless intergluteal swelling which was diagnosed clinically as a pilonidal cyst. However, on excision, he was found to have a subcutaneous sacrococcygeal...
Diffuse epithelioid malignant mesothelioma of the pleura presenting as a hydropneumothorax and vertebral body invasion: Malignant mesothelioma is an uncommon form of neoplastic transformation of the mesothelial cells that line the serosal surfaces of the body. It most commonly affects the pleura and is often associated with pleural effusions and pleural-based masses. The annual incidence in the United States is only 3300 cases, representing less than 0.3% of all cancers worldwide, although this is...
Activation of paulomycin production by exogenous γ -butyrolactone signaling molecules in Streptomyces albidoflavus J1074: AbstractThe interspecies communication roles of γ-butyrolactones (GBLs) have been described for a long time but are still poorly understood. Herein, we analyzed more than 1000 Streptomyces strains and noticed a big quantitative gap between the strains with GBL biosynthetic genes and the strains with GBL receptor genes, which implies the wide-spread of GBLs as interspecies signals...
Development and evaluation of a gp85 protein-based subgroup-specific indirect enzyme-linked immunosorbent assay for the detection of anti-subgroup J avian leukosis virus antibodies: AbstractAvian leukosis virus subgroup J (ALV-J) is an important pathogen for various neoplasms and causes significant economic losses in the poultry industry. Serological detection of specific antibodies against ALV-J infection is important for successful clinical diagnosis. Here, a 293F stable cell line was established...
Viruses, Vol. 12, Pages 58: Infection with Foamy Virus in Wild Ruminants—Evidence for a New Virus Reservoir?: Viruses, Vol. 12, Pages 58: Infection with Foamy Virus in Wild Ruminants—Evidence for a New Virus Reservoir?Viruses doi: 10.3390/v12010058Authors: Magdalena Materniak-Kornas Martin Löchelt Jerzy Rola Jacek Kuźmak Foamy viruses (FVs) are widely distributed and infect many animal species including non-human primates, horses, cattle, and cats. Several reports also suggest that other...
Viruses, Vol. 12, Pages 57: A Polymorphism in the Catalase Gene Promoter Confers Protection against Severe RSV Bronchiolitis: Viruses, Vol. 12, Pages 57: A Polymorphism in the Catalase Gene Promoter Confers Protection against Severe RSV BronchiolitisViruses doi: 10.3390/v12010057Authors: Jeffrey M. Chambliss Maria Ansar John P. Kelley Heidi Spratt Roberto P. Garofalo Antonella Casola Respiratory syncytial virus (RSV) infection is associated with oxidative lung injury, decreased levels...
Enterocele Presenting as Anterior Rectal Prolapse: Resolution with Vaginal Repair: An enterocele is a pelvic hernia formed from the separation of endopelvic fascia, associated with the posterior or anterior vaginal fornix, and most commonly located in the posterior superior vaginal segment. Rectal prolapse is a debilitating condition in which the mucosa of the rectum protrudes circumferentially from the anus. Surgical repair is the recommended treatment for rectal prolapse, and though there are many...
Large Orbital Pediatric Intraosseous Hemangioma: A five-year-old male presenting with progressive right facial swelling underwent multiple biopsies before being diagnosed with a polyostotic frontal-zygomatic primary intraosseous hemangioma. Intraosseous hemangiomas are rare, more frequently afflict adult females, and very rarely involve the orbit. Our case with bony destruction and surrounding soft tissue mass measured 5.3 cm in a child mimicked a more ominous malignancy. This case is unique with...
Overexpression of miR-375 Protects Cardiomyocyte Injury following Hypoxic-Reoxygenation Injury: The aim of the study was to evaluate the clinical significance of microRNA-375 in acute myocardial infarction patients and its mimic action in hypoxia/reoxygenation- (H/R-) induced ventricular cardiomyocyte H9c2 injury. In the current study, 90 ST-elevated acute MI patients (STEMI), 75 non-ST-elevated acute MI patients (NSTEMI), 90 healthy subjects, 14 weeks old mice, and ventricular cardiomyocyte H9c2...

The Phosphatase PHLPP2 Plays a Key Role in the Regulation of Pancreatic Beta-Cell Survival: Currently available antidiabetic treatments fail to halt, and may even exacerbate, pancreatic β-cell exhaustion, a key feature of type 2 diabetes pathogenesis; thus, strategies to prevent, or reverse, β-cell failure should be actively sought. The serine threonine kinase Akt has a key role in the regulation of β-cell homeostasis; among Akt modulators, a central role is played by pleckstrin homology domain leucine-rich...
Continuous endoglin (CD105) overexpression disrupts angiogenesis and facilitates tumor cell metastasis: AbstractEndoglin (CD105) is an auxiliary receptor for members of the TFG-β superfamily. Whereas it has been demonstrated that the deficiency of endoglin leads to minor and defective angiogenesis, little is known about the effect of its increased expression, characteristic of several types of cancer. Angiogenesis is essential for tumor growth, so high levels of proangiogenic molecules, such as endoglin,...
Intrahepatic bacterial metataxonomic signature in non-alcoholic fatty liver disease: ObjectiveWe aimed to characterise the liver tissue bacterial metataxonomic signature in two independent cohorts of patients with biopsy-proven non-alcoholic fatty liver disease (NAFLD) diagnosis, as differences in the host phenotypic features—from moderate to severe obesity—may be associated with significant changes in the microbial DNA profile.Design and methodsLiver tissue samples from 116 individuals, comprising...
Impairment of spermatogenesis and sperm motility by the high-fat diet-induced dysbiosis of gut microbes: ObjectiveHigh-fat diet (HFD)-induced metabolic disorders can lead to impaired sperm production. We aim to investigate if HFD-induced gut microbiota dysbiosis can functionally influence spermatogenesis and sperm motility.DesignFaecal microbes derived from the HFD-fed or normal diet (ND)-fed male mice were transplanted to the mice maintained on ND. The gut microbes, sperm count and motility were...
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