Δευτέρα, 30 Δεκεμβρίου 2019

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com, Telephone consultation 11855 int 1193,


Metabolism of Reactive Oxygen Species in Osteosarcoma and Potential Treatment Applications
Cells, Vol. 9, Pages 87: Metabolism of Reactive Oxygen Species in Osteosarcoma and Potential Treatment Applications: Cells, Vol. 9, Pages 87: Metabolism of Reactive Oxygen Species in Osteosarcoma and Potential Treatment ApplicationsCells doi: 10.3390/cells9010087Authors: Wei Sun Bing Wang Xing-Long Qu Bi-Qiang Zheng Wen-Ding Huang Zheng-Wang Sun Chun-Meng Wang Yong Chen Background: The present study was designed to explore the underlying role of hypoxia-inducible factor 1α (HIF-1α)...
Medicine by Alexandros G. Sfakianakis
10:15
Mechanical Deformation Mediated Transmembrane Transport
Mechanical Deformation Mediated Transmembrane Transport: Transmembrane transport is reported to be controlled dynamically and precisely, yet without restructuring molecules by mechanical deformation. This strategy can dynamically regulate the transport of molecules across liposomal bilayer by stretching and loosening. The transport can be switched on and off, and accurately tuned by varying strain. The entire transport process can be simply regulated by applying external mechanical force. AbstractTransmembrane...
Medicine by Alexandros G. Sfakianakis
10:15
Conversion Surgery in Metastatic Gastric Cancer and Cancer Dormancy as a Prognostic Biomarker
Cancers, Vol. 12, Pages 86: Conversion Surgery in Metastatic Gastric Cancer and Cancer Dormancy as a Prognostic Biomarker: Cancers, Vol. 12, Pages 86: Conversion Surgery in Metastatic Gastric Cancer and Cancer Dormancy as a Prognostic BiomarkerCancers doi: 10.3390/cancers12010086Authors: Hun Jee Choe Jin Won Kim Song-Hee Han Ju Hyun Lee Sang-Hoon Ahn Do Joong Park Ji-Won Kim Yu Jung Kim Hye Seung Lee Jee Hyun Kim Hyung-Ho Kim Keun-Wook Lee The role of conversion surgery in...
Medicine by Alexandros G. Sfakianakis
10:14
Admissions for ambulatory care sensitive conditions on rural islands and their association with patient experience
Admissions for ambulatory care sensitive conditions on rural islands and their association with patient experience: a multicentred prospective cohort study: ObjectivesThe rate of admissions for ambulatory care sensitive conditions (ACSCs) is a key outcome indicator for primary care, and patient experience (PX) is a crucial process indicator. Studies have reported higher rates of admission for ACSCs in rural areas than in urban areas. Whether there is an association between admissions for ACSCs and...
Medicine by Alexandros G. Sfakianakis
10:14
Is there a causal relationship between acute stage sensorimotor cortex activity and the development of chronic low back pain?
Is there a causal relationship between acute stage sensorimotor cortex activity and the development of chronic low back pain? a protocol and statistical analysis plan: IntroductionWhy some people develop chronic pain following an acute episode of low back pain is unknown. Recent cross-sectional studies have suggested a relationship between aberrant sensorimotor cortex activity and pain persistence. The UPWaRD (Understanding persistent Pain Where it ResiDes) cohort study is the first prospective,...
Medicine by Alexandros G. Sfakianakis
10:13
Paid disability support for adults with acquired neurological disability and complex needs
Understanding the factors that influence the quality of paid disability support for adults with acquired neurological disability and complex needs: a scoping review protocol: IntroductionAdults with disability as the result of an acquired neurological disorder often have varying and complex support needs. Consequently, adults with complex needs often require paid support to enable them to exercise choice and control and participate fully and effectively in society. Given support is so critical for...
Medicine by Alexandros G. Sfakianakis
10:13
Tonsil-Derived Mesenchymal Stem Cells
Cells, Vol. 9, Pages 89: Tensin-3 Regulates Integrin-Mediated Proliferation and Differentiation of Tonsil-Derived Mesenchymal Stem Cells: Cells, Vol. 9, Pages 89: Tensin-3 Regulates Integrin-Mediated Proliferation and Differentiation of Tonsil-Derived Mesenchymal Stem CellsCells doi: 10.3390/cells9010089Authors: Gi Cheol Park Hyung-Sik Kim Hee-Young Park Yoojin Seo Ji Min Kim Sung-Chan Shin Hyun-Keun Kwon Eui-Suk Sung Jin-Choon Lee Byung-Joo Lee Human palatine tonsils are potential...
Medicine by Alexandros G. Sfakianakis
10:12
PP2A Deficiency Enhances Carcinogenesis of Lgr5+ Intestinal Stem Cells Both in Organoids and In Vivo
Cells, Vol. 9, Pages 90: PP2A Deficiency Enhances Carcinogenesis of Lgr5+ Intestinal Stem Cells Both in Organoids and In Vivo: Cells, Vol. 9, Pages 90: PP2A Deficiency Enhances Carcinogenesis of Lgr5+ Intestinal Stem Cells Both in Organoids and In VivoCells doi: 10.3390/cells9010090Authors: Yu-Ting Yen May Chien Yung-Chih Lai Dao-Peng Chen Cheng-Ming Chuong Mien-Chie Hung Shih-Chieh Hung In most cancers, cellular origin and the contribution of intrinsic and extrinsic factors toward...
Medicine by Alexandros G. Sfakianakis
10:12
HbA1c variability in adults with type 1 diabetes on continuous subcutaneous insulin infusion (CSII) therapy compared to multiple daily injection (MDI) treatment
HbA1c variability in adults with type 1 diabetes on continuous subcutaneous insulin infusion (CSII) therapy compared to multiple daily injection (MDI) treatment: ObjectiveTo determine if continuous subcutaneous insulin infusion (CSII) therapy is associated with lower glycated haemoglobin (HbA1c) variability (long-term glycaemic variability; GV) relative to multiple daily injection (MDI) treatment in adults with type 1 diabetes mellitus (T1DM).DesignRetrospective audit.Setting and participantsClinic...
Medicine by Alexandros G. Sfakianakis
10:12
Which public health interventions are effective in reducing morbidity, mortality and health inequalities from infectious diseases amongst children in low-income and middle-income countries (LMICs): protocol for an umbrella review
Which public health interventions are effective in reducing morbidity, mortality and health inequalities from infectious diseases amongst children in low-income and middle-income countries (LMICs): protocol for an umbrella review: IntroductionDespite significant progress in the last few decades, infectious diseases remain a significant threat to children's health in low-income and middle-income countries. Effective means of prevention and control for these diseases exist, making any differences in...
Medicine by Alexandros G. Sfakianakis
10:11
Medical education quality assurance
Realist evaluation of UK medical education quality assurance: ObjectivesThe aim of the study was to explore what components of the General Medical Council's (GMC) Quality Assurance Framework work, for whom, in what circumstances and how?SettingUK undergraduate and postgraduate medical education and training.ParticipantsWe conducted interviews with a stratified sample of 36 individuals. This included those who had direct experiences, as well as those with external insights, representing local, national...
Medicine by Alexandros G. Sfakianakis
10:11
AMEND study protocol: a case-control study to assess the long-term impact of invasive meningococcal disease
AMEND study protocol: a case-control study to assess the long-term impact of invasive meningococcal disease in Australian adolescents and young adults: IntroductionInvasive meningococcal disease (IMD) primarily causes disease in young children and adolescents and can cause long-term disability. Many countries are considering implementation of meningococcal B and/or meningococcal ACWY vaccines to control meningococcal disease. Estimating the cost-effectiveness of meningococcal vaccine programme is...
Medicine by Alexandros G. Sfakianakis
10:11
Feasibility study of early outpatient review and early cardiac rehabilitation after cardiac surgery
Feasibility study of early outpatient review and early cardiac rehabilitation after cardiac surgery: mixed-methods research design--a study protocol: IntroductionFollowing cardiac surgery, patients currently attend an outpatient review 6 weeks after hospital discharge, where recovery is assessed and suitability to commence cardiac rehabilitation (CR) is determined. CR is then started from 8 weeks. Following a median sternotomy, cardiac surgery patients are required to refrain from upper body exercises,...
Medicine by Alexandros G. Sfakianakis
10:10
Housing situation and healthcare for patients in a psychiatric centre
Housing situation and healthcare for patients in a psychiatric centre in Berlin, Germany: a cross-sectional patient survey: ObjectiveTo determine the housing situation among people seeking psychiatric treatment in relation to morbidity and service utilisation.DesignCross-sectional patient survey.SettingPsychiatric centre with a defined catchment area in Berlin, Germany, March–September 2016.Participants540 psychiatric inpatients including day clinics (43.2% of all admitted patients in the study period...
Medicine by Alexandros G. Sfakianakis
10:10
Supporting people with type 2 diabetes
Supporting people with type 2 diabetes in effective use of their medicine through mobile health technology integrated with clinical care (SuMMiT-D Feasibility): a randomised feasibility trial protocol: IntroductionType 2 diabetes is common, affecting over 400 million people worldwide. Risk of serious complications can be reduced through use of effective treatments and active self-management. However, people are often concerned about starting new medicines and face difficulties in taking them regularly....
Medicine by Alexandros G. Sfakianakis
10:10
Safety of switching from vitamin K antagonist to non-vitamin K antagonist oral anticoagulant in frail elderly with atrial fibrillation: rationale and design of the FRAIL-AF randomised controlled trial
Safety of switching from vitamin K antagonist to non-vitamin K antagonist oral anticoagulant in frail elderly with atrial fibrillation: rationale and design of the FRAIL-AF randomised controlled trial: IntroductionClinical guidelines recommend non-vitamin K antagonist oral anticoagulants (NOACs) over vitamin K antagonists (VKAs) for stroke prevention in most patients with atrial fibrillation (AF). Frail elderly were under-represented in the landmark NOAC-trials, leaving a knowledge gap on the optimal...
Medicine by Alexandros G. Sfakianakis
10:09
Fatty acid profile and in vitro biological properties of two Rosacea species (Pyrus glabra and Pyrus syriaca)
Fatty acid profile and in vitro biological properties of two Rosacea species (Pyrus glabra and Pyrus syriaca), grown as wild in Iran: One of the most important findings of this study is the introduction of Pyrus glabra and Pyrus syriaca as a new source of plant oils. The significant amount of antioxidants, especially in P. glabra oil, may serve as a dietary source of natural antioxidants and increase the stability and quality of food products. The results showed that the P. glabra seed oil is rich...
Medicine by Alexandros G. Sfakianakis
10:09
Sleep problems of healthcare workers in tertiary hospital
Sleep problems of healthcare workers in tertiary hospital and influencing factors identified through a multilevel analysis: a cross-sectional study in China: ObjectivesSleep problems are common among healthcare workers, especially among those who work in tertiary hospitals; however, studies focusing on healthcare workers in tertiary hospitals in China are limited. Therefore, we aimed to examine the prevalence of sleep problems among tertiary hospital employees in China and identify associated factors.DesignCross-sectional...
Medicine by Alexandros G. Sfakianakis
10:08
Improving chronic pain management with eHealth and mHealth
Improving chronic pain management with eHealth and mHealth: study protocol for a randomised controlled trial: IntroductionChronic pain has become a matter of public health concern due to its high prevalence and because public costs associated with treatment and disability increase each year. Research suggests that limitations in the traditional assessment of chronic pain patients limit the effectiveness of current medical treatments. The use of technology might serve change patient traditional monitoring...
Medicine by Alexandros G. Sfakianakis
10:08
Healthcare utilisation for eating disorders among patients with depression
Healthcare utilisation for eating disorders among patients with depression: a cross-sectional study in Taiwan: ObjectivesAlthough depressed patients may have a comorbid eating disorder (ED), to date, no study has focused on healthcare utilisation among this population. This study was designed to investigate the characteristics of healthcare service utilisation among depressed patients with ED.DesignA cross-sectional study.SettingThis population-based study used claims data from Taiwan's National...
Medicine by Alexandros G. Sfakianakis
10:07
Effect of involving certified healthcare assistants in primary care
Effect of involving certified healthcare assistants in primary care in Germany: a cross-sectional study: ObjectivesGrowing prevalence of chronic diseases and limited resources are the key challenges for future healthcare. As a promising approach to maintain high-quality primary care, non-physician healthcare professionals have been trained to broaden qualifications and responsibilities. This study aimed to assess the influence of involving certified healthcare assistants (HCAs, German: Versorgungsassistent/in...
Medicine by Alexandros G. Sfakianakis
10:04
Womens health-related vulnerabilities in natural disasters
Womens health-related vulnerabilities in natural disasters: a systematic review protocol: IntroductionThere is a paucity of evidence identifying both the physical and psychological health risks and underlying causes of women's health-related vulnerabilities related to natural disasters. Therefore, this systematic review will be conducted to determine the impact of natural disasters on women's health from a global perspective.Methods and analysisFive electronic databases of health research, including...
Medicine by Alexandros G. Sfakianakis
10:04
Family-building decision aid and planning tool for young adult women after cancer treatment: protocol for preliminary testing of a web-based decision support intervention in a single-arm pilot study
Family-building decision aid and planning tool for young adult women after cancer treatment: protocol for preliminary testing of a web-based decision support intervention in a single-arm pilot study: IntroductionMany young adult female (YA-F) cancer survivors who received gonadotoxic therapy will experience fertility problems. After cancer, having a child will often require assisted reproductive technology (ART), surrogacy or adoption. However, there are significant informational, psychosocial, financial...
Medicine by Alexandros G. Sfakianakis
10:04
Adverse events and good practices in maternity wards
Multicentre cross-sectional study on adverse events and good practices in maternity wards in Brazil and Mexico: same problems, different magnitude: ObjectiveTo evaluate the quality of delivery care in maternity wards in Brazil and Mexico based on good practices (GP) and adverse events (AE), in order to identify priorities for improvement.DesignA multicentre cross-sectional study with data collection from medical records between 2015 and 2016 to compare indicators of maternal and neonatal GP and EA...
Medicine by Alexandros G. Sfakianakis
10:00
Does 'online confidence predict application success and later academic performance in medical school?
Does 'online confidence predict application success and later academic performance in medical school? A UK-based national cohort study: ObjectivesThe UK Clinical Aptitude Test (UKCAT) previously piloted an assessment of 'online confidence', where candidates were asked to indicate how confident they were with their answers. This study examines the relationship between these ratings, the odds of receiving an offer to study medicine and subsequent undergraduate academic performance.DesignNational cohort...
Medicine by Alexandros G. Sfakianakis
10:00

Healthcare in rural and underserved areas : Cost-effectiveness analysis of a physician deployment program to improve access
Cost-effectiveness analysis of a physician deployment program to improve access to healthcare in rural and underserved areas in the Philippines: ObjectivesThe objective of this study is to explore the cost-effectiveness of Doctor to the Barrios (DTTB), a physician deployment program in the Philippines.DesignCost-effectiveness analysis using decision tree models with a lifetime time horizon and probabilistic sensitivity analysis.SettingSocietal and healthcare perspectives.PopulationHypothetical cohort...
Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης
09:59
Increased risk of bullous pemphigoid in dipeptidyl peptidase 4 inhibitors
Increased risk of bullous pemphigoid in dipeptidyl peptidase 4 inhibitors: A nationwide, population‐based, cohort study in Taiwan: AbstractRecent studies revealed the risk of bullous pemphigoid (BP) in patients with diabetes mellitus (DM) taking dipeptidyl peptidase 4 (DPP‐4) inhibitors. To clarify the relationship between taking DPP‐4 inhibitors and the risk of BP among patients with DM, we conducted a cohort study by using the National Health Insurance Research Database of Taiwan from 1 January...
Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης
09:58
Successful Treatment of verruca plana with NB‐UVB: A Case report
Successful Treatment of verruca plana with NB‐UVB: A Case report: AbstractVerruca plana is a kind of benign proliferative skin disease that generally occurs in exposed parts, but the treatment of warts poses a therapeutic challenge for physicians, as there is no method, among numerous approaches, that has been proven effective for completely curing this disease. We report a case of verruca plana cured by narrow‐band ultraviolet B (NB‐UVB), which provides a new treatment of verruca plana.This article...
Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης
09:58
Effect of Q‐switched Nd‐YAG laser on the clinical, pigmentary and immunological markers in the patients with lichen planus pigmentosus: A pilot study
Effect of Q‐switched Nd‐YAG laser on the clinical, pigmentary and immunological markers in the patients with lichen planus pigmentosus: A pilot study: AbstractThe persistent discolouration in lichen planus pigmentosus is secondary to persistent melanophages in superficial dermis in these patients. We evaluated the effect of Q‐switched Nd‐YAG laser on the clinical, pigmentary and immunological markers in the patients with lichen planus pigmentosus. Nine females with a clinical diagnosis of lichen...
Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης
09:57
Microbial activities associated with human intestinal mucosal biofilms change mRNAs and microRNAs to promote carcinogenesis in mice [miRNA]
GSE108164 Microbial activities associated with human intestinal mucosal biofilms change mRNAs and microRNAs to promote carcinogenesis in mice [miRNA]: Contributors : Cynthia Sears ; Christian JobinSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusDisrupted interactions between host and intestinal bacteria are implicated in the development of colorectal cancer (CRC). However, the functional impacts of these inter-kingdom interactions remain poorly defined....
Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης
09:56
Genes, Vol. 11, Pages 44: Porcine Epidemic Diarrhea Altered Colonic Microbiota Communities in Suckling Piglets
Genes, Vol. 11, Pages 44: Porcine Epidemic Diarrhea Altered Colonic Microbiota Communities in Suckling Piglets: Genes, Vol. 11, Pages 44: Porcine Epidemic Diarrhea Altered Colonic Microbiota Communities in Suckling PigletsGenes doi: 10.3390/genes11010044Authors: Zhen Tan Wanting Dong Yaqun Ding Xiangdong Ding Qin Zhang Li Jiang Porcine epidemic diarrhea (PED) is a major gastrointestinal disease afflicting suckling pigs that causes huge industrial economic losses. In this study, we investigated...
Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης
09:55
The Practice of Pharmaceutics and the Obligation to Expand Access to Investigational Drugs
The Practice of Pharmaceutics and the Obligation to Expand Access to Investigational Drugs: AbstractDo pharmaceutical companies have a moral obligation to expand access to investigational drugs to patients outside the clinical trial? One reason for thinking they do not is that expanded access programs might negatively affect the clinical trial process. This potential impact creates dilemmas for practitioners who nevertheless acknowledge some moral reason for expanding access. Bioethicists have explained...
Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης
09:55
SEOM clinical guidelines in hereditary breast and ovarian cancer (2019)
SEOM clinical guidelines in hereditary breast and ovarian cancer (2019): AbstractMutations in BRCA1 and BRCA2 high penetrance genes account for most hereditary breast and ovarian cancer, although other new high-moderate penetrance genes included in multigene panels have increased the genetic diagnosis of hereditary breast and ovarian cancer families by 50%. Multigene cancer panels provide new challenges related to increased frequency of variants of uncertain significance, new gene-specific cancer...
Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης
09:55
Elevated Intraocular Pressure Causes Abnormal Reactivity of Mouse Retinal Arterioles
Elevated Intraocular Pressure Causes Abnormal Reactivity of Mouse Retinal Arterioles: Objective. Glaucoma is a leading cause of severe visual impairment and blindness. Although high intraocular pressure (IOP) is an established risk factor for the disease, the role of abnormal ocular vessel function in the pathophysiology of glaucoma gains more and more attention. We tested the hypothesis that elevated intraocular pressure (IOP) causes vascular dysfunction in the retina. Methods. High IOP was induced...
Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης
09:55

Restoration of Autophagic Flux Rescues Oxidative Damage and Mitochondrial Dysfunction to Protect against Intervertebral Disc Degeneration
Restoration of Autophagic Flux Rescues Oxidative Damage and Mitochondrial Dysfunction to Protect against Intervertebral Disc Degeneration: Oxidative stress-induced mitochondrial dysfunction and nucleus pulposus (NP) cell apoptosis play crucial roles in the development of intervertebral disc degeneration (IDD). Increasing studies have shown that interventions targeting impaired autophagic flux can maintain cellular homeostasis by relieving oxidative damage. Here, we investigated the effect of curcumin...
Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης
09:54
The Evolution of Positive and Negative Affect in a Longitudinal Sample of Children and Adolescents
The Evolution of Positive and Negative Affect in a Longitudinal Sample of Children and Adolescents: AbstractThis article explores the evolution of Positive and Negative Affect (PA and NA) and their relationship with a single-item measure of overall life satisfaction (OLS) through a five-year longitudinal study on 1696 ten to eighteen-year-olds in Catalonia (Spain). The results, which were obtained through structural equation modelling with a cross-lagged panel, show that mean scores for both PA and...
Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης
09:37
Antibiotics, Vol. 9, Pages 10: Simple Carbohydrate Derivatives Diminish the Formation of Biofilm of the Pathogenic Yeast Candida albicans
Antibiotics, Vol. 9, Pages 10: Simple Carbohydrate Derivatives Diminish the Formation of Biofilm of the Pathogenic Yeast Candida albicans: Antibiotics, Vol. 9, Pages 10: Simple Carbohydrate Derivatives Diminish the Formation of Biofilm of the Pathogenic Yeast Candida albicansAntibiotics doi: 10.3390/antibiotics9010010Authors: Olena P. Ishchuk Olov Sterner Ulf Ellervik Sophie Manner The opportunistic human fungal pathogen Candida albicans relies on cell morphological transitions to develop...
Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης
09:37
Medgadget's Best Medical Technologies of 2019
Medgadget's Best Medical Technologies of 2019: Wrapping up this year and looking back on the particularly interesting developments in medical technology, we at Medgadget are impressed and very excited about the future. We're lucky to cover one of the most innovative fields of research and one that improves and saves lives. Having a constant eye on what's new in medtech, we present what we believe are the most novel, smart, and medically important technologies we encountered in this passing year....
Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης
09:36
Description of a disease activity proforma for documentation of hidradenitis suppurativa severity and distribution, and suggestions for use as a patient‐reported outcome measure
Description of a disease activity proforma for documentation of hidradenitis suppurativa severity and distribution, and suggestions for use as a patient‐reported outcome measure: AbstractThe whole process is intuitive and can be completed in under five minutes using a combination of clinical examination and verbal patient questioning. The completed proforma enables the clinician to visualise a concise but comprehensive overview of HS activity and distribution for an individual patient. In addition...
Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης
09:35
Cancers, Vol. 12, Pages 85: Molecular Genetics of Renal Cell Tumors: A Practical Diagnostic Approach
Cancers, Vol. 12, Pages 85: Molecular Genetics of Renal Cell Tumors: A Practical Diagnostic Approach: Cancers, Vol. 12, Pages 85: Molecular Genetics of Renal Cell Tumors: A Practical Diagnostic ApproachCancers doi: 10.3390/cancers12010085Authors: Reza Alaghehbandan Delia Perez Montiel Ana Silvia Luis Ondrej Hes Renal epithelial cell tumors are composed of a heterogeneous group of tumors with variable morphologic, immunohistochemical, and molecular features. A "histo-molecular" approach is...
Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης
09:34
Cancers, Vol. 12, Pages 84: Real-World Data on Cabozantinib in Previously Treated Patients with Metastatic Renal Cell Carcinoma: Focus on Sequences and Prognostic Factors
Cancers, Vol. 12, Pages 84: Real-World Data on Cabozantinib in Previously Treated Patients with Metastatic Renal Cell Carcinoma: Focus on Sequences and Prognostic Factors: Cancers, Vol. 12, Pages 84: Real-World Data on Cabozantinib in Previously Treated Patients with Metastatic Renal Cell Carcinoma: Focus on Sequences and Prognostic FactorsCancers doi: 10.3390/cancers12010084Authors: Matteo Santoni Daniel Y. Heng Sergio Bracarda Giuseppe Procopio Michele Milella Camillo Porta Marc R....
Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης
09:34
Cells, Vol. 9, Pages 88: Vertically-Aligned Functionalized Silicon Micropillars for 3D Culture of Human Pluripotent Stem Cell-Derived Cortical Progenitors
Cells, Vol. 9, Pages 88: Vertically-Aligned Functionalized Silicon Micropillars for 3D Culture of Human Pluripotent Stem Cell-Derived Cortical Progenitors: Cells, Vol. 9, Pages 88: Vertically-Aligned Functionalized Silicon Micropillars for 3D Culture of Human Pluripotent Stem Cell-Derived Cortical ProgenitorsCells doi: 10.3390/cells9010088Authors: Alessandro Cutarelli Simone Ghio Jacopo Zasso Alessandra Speccher Giorgina Scarduelli Michela Roccuzzo Michele Crivellari Nicola Maria...
Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης
09:34
Toxins, Vol. 12, Pages 16: Ephedra sinica Stapf and Gypsum Attenuates Heat-Induced Hypothalamic Inflammation in Mice
Toxins, Vol. 12, Pages 16: Ephedra sinica Stapf and Gypsum Attenuates Heat-Induced Hypothalamic Inflammation in Mice: Toxins, Vol. 12, Pages 16: Ephedra sinica Stapf and Gypsum Attenuates Heat-Induced Hypothalamic Inflammation in MiceToxins doi: 10.3390/toxins12010016Authors: Wonnam Kim Wonil Lee Eugene Huh Eunjung Choi Young Pyo Jang Yun-Kyung Kim Tae-Hee Lee Myung Sook Oh Ephedra sinica Stapf (EH) exert toxic effects, such as excitability, cardiac arrhythmia, and others. On the...
Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης
09:34
Is Surgery-first Still a Reasonable Option in the Era of Neoadjuvant Chemotherapy for Resectable Pancreatic Cancer?
Is Surgery-first Still a Reasonable Option in the Era of Neoadjuvant Chemotherapy for Resectable Pancreatic Cancer?: The incidence of pancreatic ductal adenocarcinoma has risen rapidly. By 2030, it is likely to be the second most prevalent cause of death by cancer, following cancer of the lung. Unfortunately, most patients present with advanced disease. In fact, only 20% of patients are candidates for surgery. More research is needed to find dependable treatment options for this disease. Although...
Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης
09:33
SEOM clinical guidelines in hereditary breast and ovarian cancer (2019)
SEOM clinical guidelines in hereditary breast and ovarian cancer (2019): AbstractMutations in BRCA1 and BRCA2 high penetrance genes account for most hereditary breast and ovarian cancer, although other new high-moderate penetrance genes included in multigene panels have increased the genetic diagnosis of hereditary breast and ovarian cancer families by 50%. Multigene cancer panels provide new challenges related to increased frequency of variants of uncertain significance, new gene-specific cancer...
Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης
09:33
Porous high-density polyethylene (MEDPOR)
Retraction NotePublished: 30 December 2019Retraction Note to: Management of the large septal perforations with the support of porous high-density polyethylene (MEDPOR)Ilteris Murat Emsen European Journal of Plastic Surgery (2019)Cite this articleRetraction Note to: Eur J Plast Surg (2007) 29:277–283https://doi.org/10.1007/s00238-006-0103-9The Editor-in-Chief has retracted this article [1] because significant parts of the text and Figs. 1 to 6 and 7a were duplicated from a previously published article...
Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης
09:33
Algorithmic Puzzles: History, Taxonomies, and Applications in Human Problem Solving
Algorithmic Puzzles: History, Taxonomies, and Applications in Human Problem Solving: Anany Levitin, Journal of Problem Solving, Dec 30, 2019 This is a fun read from a couple of years ago that turned up in an O'Reilly mailing list this week. While it will be of interest to psychologists and computer scientists, it will also give teachers ideas for class discussion or computation projects. The paper (15 page PDF) considers the nature or algorithmic puzzles, identifies two typologies based on the...
Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης
09:30
Tumor uptake and associated greater efficacy of anti-Her2 immunoliposome does not rely on Her2 expression status: study of a docetaxel-trastuzumab immunoliposome on Her2+ breast cancer model (SKBR3)
Tumor uptake and associated greater efficacy of anti-Her2 immunoliposome does not rely on Her2 expression status: study of a docetaxel-trastuzumab immunoliposome on Her2+ breast cancer model (SKBR3): Nanoparticles have been used for decades in breast cancer. More recently, anti-human epidermal receptor 2 (Her2) immunoliposomes are of rising interest. However, recent studies have questioned the actual relevance of using anti-Her2 antibodies to improve liposome distribution and efficacy. Using standard...
Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης
09:29
Utility of Ga68 prostate‐specific membrane antigen positron‐emission tomography for pre‐operative staging of high‐risk prostate cancer in a prospective cohort
Utility of Ga68 prostate‐specific membrane antigen positron‐emission tomography for pre‐operative staging of high‐risk prostate cancer in a prospective cohort: AbstractIntroductionTo assess the yield of Ga68 PSMA PET/CT added to the conventional staging of high‐risk prostate cancer in terms of altered staging and changes to management.MethodsPatients with high‐risk prostate cancer without metastatic disease on conventional staging referred for Ga68 PSMA PET/CT at Mercy Radiology, Auckland, New Zealand,...
Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης
09:28
Why considering sexual differences is necessary when studying encephalopathy of prematurity through rodent models
Why considering sexual differences is necessary when studying encephalopathy of prematurity through rodent models: AbstractPreterm birth is a high‐risk factor for the development of gray and white matter abnormalities, referred to as "encephalopathy of prematurity," that may lead to life‐long motor, cognitive, and behavioral impairments. The prevalence and clinical outcomes of encephalopathy of prematurity differ between sexes, and elucidating the underlying biological basis has become a high‐priority...
Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης
09:28
The Invention of "Ethical AI": How Big Tech Manipulates Academia to Avoid Regulation
The Invention of "Ethical AI": How Big Tech Manipulates Academia to Avoid Regulation: Rodrigo Ochigame, The Intercept, Dec 30, 2019 According to this article, "Silicon Valley's vigorous promotion of 'ethical AI' has constituted a strategic lobbying effort, one that has enrolled academia to legitimize itself." Playing a key role in this was Joi Ito and the MIT Media Lab. "The corporate, academic, and military proponents of 'ethical AI' have collaborated closely for mutual benefit," writes Rodrigo...
Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης
09:28
Health and Occupational Injury Experienced by Child Farmworkers
IJERPH, Vol. 17, Pages 248: Health and Occupational Injury Experienced by Latinx Child Farmworkers in North Carolina, USA: IJERPH, Vol. 17, Pages 248: Health and Occupational Injury Experienced by Latinx Child Farmworkers in North Carolina, USAInternational Journal of Environmental Research and Public Health doi: 10.3390/ijerph17010248Authors: Thomas A. Arcury Taylor J. Arnold Sara A. Quandt Haiying Chen Gregory D. Kearney Joanne C. Sandberg Jennifer W. Talton Melinda F. Wiggins ...
Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης
09:24
Assessing and Improving the Quality in Mental Health Services
IJERPH, Vol. 17, Pages 249: Assessing and Improving the Quality in Mental Health Services: IJERPH, Vol. 17, Pages 249: Assessing and Improving the Quality in Mental Health ServicesInternational Journal of Environmental Research and Public Health doi: 10.3390/ijerph17010249Authors: Lampros Samartzis Michael A. Talias Background: The mental health of the population consists of the three essential pillars of quality of life, economy, and society. Mental health services take care of the prevention...
Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης
09:23
Potency of Papaya Leaf (Carica papaya L.) as Toxicant and Repellent against German Cockroach (Blattella germanica L.)
Potency of Papaya Leaf (Carica papaya L.) as Toxicant and Repellent against German Cockroach (Blattella germanica L.): Background and Objective: Papaya leaves have the potency to be developed as alternative insecticide to control the German cockroaches that have been resistant to synthetic insecticides. This study aimed to determine the potency of ethanolic extract of papaya leaf as toxicant and repellent against 2 populations of German cockroaches which are known resistant to synthetic insecticide....
Medicine by Alexandros G. Sfakianakis
09:22

Hypoglycemic Potential of Supplementation with a Vegetable and Legume Juice Formula in Type 2 Diabetic Patients
Hypoglycemic Potential of Supplementation with a Vegetable and Legume Juice Formula in Type 2 Diabetic Patients: Background and Objective: Type 2 diabetes affects a large number of people all over the world; hence, it is worthy to supplement those patients with a food formula containing biologically active ingredients that can help to control the disease and its complications. The present study was designed to prepare a plant formula in the form of a juice taken during treatment to synergies and...
Medicine by Alexandros G. Sfakianakis
09:20
Common Co-morbidities Are Challenging in the Diagnosis of Middle East Respiratory Syndrome (MERS-CoV) in Saudi Arabia
Common Co-morbidities Are Challenging in the Diagnosis of Middle East Respiratory Syndrome (MERS-CoV) in Saudi Arabia: Background and Objective: Middle East respiratory syndrome coronavirus (MERS-CoV) is a relatively recent human disease reported initially in Saudi Arabia in September, 2012. Morbidities investigation includes a process of excluding other possible options until certain suspected cases are confirmed. Material and Methods: In this study, we formulated a model under the authorization...
Medicine by Alexandros G. Sfakianakis
09:20
Symbiotic collision tumour of the scalp: squamous cell carcinoma and malignant melanoma
Symbiotic collision tumour of the scalp: squamous cell carcinoma and malignant melanoma: AbstractCutaneous collision tumours are the co‐existence of two tumours of different histopathological morphologies that coincide at the same or adjacent anatomical sites. A large scalp nodule excised from a 70 year‐old man revealed a collision tumour composed of cells of squamous carcinoma (SCC) and malignant melanoma. Immunohistochemistry using dual staining for melanoma and squamous cell carcinoma demonstrated...
Medicine by Alexandros G. Sfakianakis
09:19
Antioxidants, Vol. 9, Pages 32: Protective Role of Peroxiredoxins against Reactive Oxygen Species in Neonatal Rat Testicular Gonocytes
Antioxidants, Vol. 9, Pages 32: Protective Role of Peroxiredoxins against Reactive Oxygen Species in Neonatal Rat Testicular Gonocytes: Antioxidants, Vol. 9, Pages 32: Protective Role of Peroxiredoxins against Reactive Oxygen Species in Neonatal Rat Testicular GonocytesAntioxidants doi: 10.3390/antiox9010032Authors: Cristian O'Flaherty Annie Boisvert Gurpreet Manku Martine Culty Peroxiredoxins (PRDXs) are antioxidant enzymes that protect cells from oxidative stress and play a role in reactive...
Medicine by Alexandros G. Sfakianakis
09:19
Viruses, Vol. 12, Pages 41: Investigation of the Role of the Spike Protein in Reversing the Virulence of the Highly Virulent Taiwan Porcine Epidemic Diarrhea Virus Pintung 52 Strains and Its Attenuated Counterpart
Viruses, Vol. 12, Pages 41: Investigation of the Role of the Spike Protein in Reversing the Virulence of the Highly Virulent Taiwan Porcine Epidemic Diarrhea Virus Pintung 52 Strains and Its Attenuated Counterpart: Viruses, Vol. 12, Pages 41: Investigation of the Role of the Spike Protein in Reversing the Virulence of the Highly Virulent Taiwan Porcine Epidemic Diarrhea Virus Pintung 52 Strains and Its Attenuated CounterpartViruses doi: 10.3390/v12010041Authors: Chi-Fei Kao Hui-Wen Chang Porcine...
Medicine by Alexandros G. Sfakianakis
09:18
Microorganisms, Vol. 8, Pages 61: Prenatal Transfer of Gut Bacteria in Rock Pigeon
Microorganisms, Vol. 8, Pages 61: Prenatal Transfer of Gut Bacteria in Rock Pigeon: Microorganisms, Vol. 8, Pages 61: Prenatal Transfer of Gut Bacteria in Rock PigeonMicroorganisms doi: 10.3390/microorganisms8010061Authors: Maurine W. Dietz Joana F. Salles Bin-Yan Hsu Cor Dijkstra Ton G. G. Groothuis Marco van der Velde Yvonne I. Verkuil B. Irene Tieleman Vertebrates evolved in concert with bacteria and have developed essential mutualistic relationships. Gut bacteria are vital for...
Medicine by Alexandros G. Sfakianakis
09:18
Gene Expression Profiling of Head and Neck Tumors Identifies FOXP1 and SOX10 Expression as Useful for Distinguishing Ameloblastoma From Basaloid Salivary Gland Tumors
Gene Expression Profiling of Head and Neck Tumors Identifies FOXP1 and SOX10 Expression as Useful for Distinguishing Ameloblastoma From Basaloid Salivary Gland Tumors: Odontogenic tumors show considerable morphologic heterogeneity and at times the diagnosis can be challenging. Ameloblastoma, the most common odontogenic tumor, can have morphologic similarity to some salivary gland tumors and therefore we sought to identify biomarkers that might aid in the diagnosis by performing transcriptome wide...
Medicine by Alexandros G. Sfakianakis
09:18
Clinical Applications, Pitfalls, and Uncertainties of Thrombin Generation in the Presence of Platelets
JCM, Vol. 9, Pages 92: Clinical Applications, Pitfalls, and Uncertainties of Thrombin Generation in the Presence of Platelets: JCM, Vol. 9, Pages 92: Clinical Applications, Pitfalls, and Uncertainties of Thrombin Generation in the Presence of PlateletsJournal of Clinical Medicine doi: 10.3390/jcm9010092Authors: Marina Panova-Noeva Paola E.J. van der Meijden Hugo ten Cate Platelet-dependent thrombin generation is a helpful tool to assess ex vivo the interaction between platelets and plasma coagulation...
Medicine by Alexandros G. Sfakianakis
09:17
Why Uptake of Blended Internet-Based Interventions for Depression Is Challenging: A Qualitative Study on Therapists' Perspectives
JCM, Vol. 9, Pages 91: Why Uptake of Blended Internet-Based Interventions for Depression Is Challenging: A Qualitative Study on Therapists' Perspectives: JCM, Vol. 9, Pages 91: Why Uptake of Blended Internet-Based Interventions for Depression Is Challenging: A Qualitative Study on Therapists' PerspectivesJournal of Clinical Medicine doi: 10.3390/jcm9010091Authors: Mayke Mol Claire van Genugten Els Dozeman Digna J. F. van Schaik Stasja Draisma Heleen Riper Jan H. Smit (1) Background:...
Medicine by Alexandros G. Sfakianakis
09:17
Journals for Dec 30th.2019
1a6ue1-xc26e.htmlMinds and Machines, Vol. 29, Issue 4 - New Issue Alert.eml 2asu1z-42vkx.htmlNervous Diseases and Mental Hygiene, Year 2019, Issue 08 -New Issue Alert..eml 3aewxb-lfl3g.htmlNew articles available for Clinical Medicine Insights_ Case Reports.eml 4acp2h-ocdmd.htmlNew articles available for Integrative Cancer Therapies.eml 5apzyx-ock1g.htmlOphthalmology in China, Year 2019, Issue 05 -New Issue Alert..eml 6axcdy-fec7g.htmlPAP Alert - Dermatologic Surgery.eml 7apmpz-cpiuh.htmlRadiologic...
Medicine by Alexandros G. Sfakianakis
09:13

70 Journals for Dec 28th.2019
Journals1apfrr-gsv90.htmlRead the latest The Journal of Strength & Conditioning Research - Vol. 34, No. 1, January 2020.eml 2abkgt-ly7fd.htmlRead the latest Transplantation - Vol. 104, No. 1, January 2020.eml 3apouu-64ym7.htmlReminder_ Get End-of-Year CME with JAMA Otolaryngology Clinical Challenges.eml 4ao6rp-sw2mv.htmlSaudi Endod J - New issue online.eml 5avesw-7q3zd.htmlScan Blog_ Investigation Following Moffitt Departures, NSF Nominee May Boost White House Ties, more.eml 6ag1ol-0gxo1.htmlSelectas...
Medicine by Alexandros G. Sfakianakis
Sat Dec 28, 2019 14:55

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