Neuroimaging of Meckel’s cave in normal and disease conditions

Abstract

Meckel's cave is a dural recess in the posteromedial portion of the middle cranial fossa that acts as a conduit for the trigeminal nerve between the prepontine cistern and the cavernous sinus, and houses the Gasserian ganglion and proximal rootlets of the trigeminal nerve. It serves as a major pathway in perineural spread of pathologies such as head and neck neoplasms, automatically upstaging tumours, and is a key structure to assess in cases of trigeminal neuralgia. The purpose of this pictorial review is threefold: (1) to review the normal anatomy of Meckel's cave; (2) to describe imaging findings that identify disease involving Meckel's cave; (3) to present case examples of trigeminal and non-trigeminal processes affecting Meckel's cave.

Teaching points

• Meckel's cave contains the trigeminal nerve ganglion and rootlets between the prepontine cistern and cavernous sinus.

• Assessment is essential for perineural spread of disease and trigeminal neuralgia.

• Key imaging: neural enhancement, enlargement, perineural fat/CSF effacement and skull base foraminal changes.

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