IJMS, Vol. 19, Pages 698: Importance of ERK1/2 in Regulation of Protein Translation during Oocyte Meiosis

IJMS, Vol. 19, Pages 698: Importance of ERK1/2 in Regulation of Protein Translation during Oocyte Meiosis

International Journal of Molecular Sciences doi: 10.3390/ijms19030698

Authors: Jaroslav Kalous Anna Tetkova Michal Kubelka Andrej Susor

Although the involvement of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) pathway in the regulation of cytostatic factor (CSF) activity; as well as in microtubules organization during meiotic maturation of oocytes; has already been described in detail; rather less attention has been paid to the role of ERK1/2 in the regulation of mRNA translation. However; important data on the role of ERK1/2 in translation during oocyte meiosis have been documented. This review focuses on recent findings regarding the regulation of translation and the role of ERK1/2 in this process in the meiotic cycle of mammalian oocytes. The specific role of ERK1/2 in the regulation of mammalian target of rapamycin (mTOR); eukaryotic translation initiation factor 4E (eIF4E) and cytoplasmic polyadenylation element binding protein 1 (CPEB1) activity is addressed along with additional focus on the other key players involved in protein translation.

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