Σάββατο 3 Φεβρουαρίου 2018

Technique adaptation, strategic replanning, and team learning during implementation of MR-guided brachytherapy for cervical cancer

Publication date: January–February 2018
Source:Brachytherapy, Volume 17, Issue 1
Author(s): Julia Skliarenko, Marco Carlone, Kari Tanderup, Kathy Han, Akbar Beiki-Ardakani, Jette Borg, Kitty Chan, Jennifer Croke, Alexandra Rink, Anna Simeonov, Reem Ujaimi, Jason Xie, Anthony Fyles, Michael Milosevic
PurposeMR-guided brachytherapy (MRgBT) with interstitial needles is associated with improved outcomes in cervical cancer patients. However, there are implementation barriers, including magnetic resonance (MR) access, practitioner familiarity/comfort, and efficiency. This study explores a graded MRgBT implementation strategy that included the adaptive use of needles, strategic use of MR imaging/planning, and team learning.Methods and MaterialsTwenty patients with cervical cancer were treated with high-dose-rate MRgBT (28 Gy in four fractions, two insertions, daily MR imaging/planning). A tandem/ring applicator alone was used for the first insertion in most patients. Needles were added for the second insertion based on evaluation of the initial dosimetry. An interdisciplinary expert team reviewed and discussed the MR images and treatment plans.ResultsDosimetry-trigger technique adaptation with the addition of needles for the second insertion improved target coverage in all patients with suboptimal dosimetry initially without compromising organ-at-risk (OAR) sparing. Target and OAR planning objectives were achieved in most patients. There were small or no systematic differences in tumor or OAR dosimetry between imaging/planning once per insertion vs. daily and only small random variations. Peer review and discussion of images, contours, and plans promoted learning and process development.ConclusionsTechnique adaptation based on the initial dosimetry is an efficient approach to implementing MRgBT while gaining comfort with the use of needles. MR imaging and planning once per insertion is safe in most patients as long as applicator shifts, and large anatomical changes are excluded. Team learning is essential to building individual and programmatic competencies.



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