Τρίτη 13 Φεβρουαρίου 2018

IJMS, Vol. 19, Pages 562: The Crosstalk between Nrf2 and Inflammasomes

IJMS, Vol. 19, Pages 562: The Crosstalk between Nrf2 and Inflammasomes

International Journal of Molecular Sciences doi: 10.3390/ijms19020562

Authors: Paulina Hennig Martha Garstkiewicz Serena Grossi Michela Di Filippo Lars French Hans-Dietmar Beer

The Nrf2 (nuclear factor E2-related factor or nuclear factor (erythroid-derived 2)-like 2) transcription factor is a key player in cytoprotection and activated in stress conditions caused by reactive oxygen species (ROS) or electrophiles. Inflammasomes represent central regulators of inflammation. Upon detection of various stress factors, assembly of the inflamasome protein complex results in activation and secretion of proinflammatory cytokines. In addition, inflammasome activation causes pyroptosis, a lytic form of cell death, which supports inflammation. There is growing evidence of a crosstalk between the Nrf2 and inflammasome pathways at different levels. For example, Nrf2 activating compounds inhibit inflammasomes and consequently inflammation. This review summarizes what is known about the complex and predominantly antagonistic relationship of both stress-activated pathways.



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