Reliability and Validity of the Atopic Dermatitis Symptom Score.
Pediatr Allergy Immunol. 2018 Jan 19;:
Authors: Lee JY, Kim M, Yang HK, Kim HM, Cho J, Kim YM, Lim IS, Cheong HK, Kim HS, Sohn I, Kim J, Ahn K
Abstract
BACKGROUND: We have developed the Atopic Dermatitis Symptom Score (ADSS) by which patients or parents can easily assess and record AD symptoms on a daily basis in a smartphone application. The aim of the present study was to evaluate the reliability and validity of the ADSS.
METHODS: We enrolled 307 children and adolescents with AD. Parents or caregivers were asked to record daily symptoms of the patients (itching, sleep disturbance, erythema, dryness, oozing, and oedema) using a scale of 0 to 4. Statistical analyses consisted of the test-retest reliability, concurrent validity, minimal clinically important difference (MCID), responsiveness, floor or ceiling effects, and screening accuracy. Receiver-operating characteristic analyses were conducted to evaluate the ADSS cut-off point for predicting severe AD (SCORing AD [SCORAD] ≥40).
RESULTS: Test-retest reliability between daytime and nighttime ADSS was good (intraclass correlation coefficient, 0.82 [95% CI: 0.70-0.90]). An increase in ADSS was significantly associated with an increase in SCORAD (r = 0.64, P < 0.0001) (concurrent validity). The MCID was 4.1 points for the ADSS. There was a significant association between changes in ADSS and SCORAD (r = 0.56, P < 0.0001), indicating good responsiveness. At the optimal ADSS cut-off value of 7.0, sensitivity, specificity, and positive and negative predictive values were 88.4%, 78.6%, 21.1%, and 99.1%, respectively (screening accuracy).
CONCLUSIONS: The ADSS can be a useful tool for self-assessment of skin symptoms in children with AD. This article is protected by copyright. All rights reserved.
PMID: 29350788 [PubMed - as supplied by publisher]
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