IJMS, Vol. 19, Pages 240: Hypoxia and Hormone-Mediated Pathways Converge at the Histone Demethylase KDM4B in Cancer

IJMS, Vol. 19, Pages 240: Hypoxia and Hormone-Mediated Pathways Converge at the Histone Demethylase KDM4B in Cancer

International Journal of Molecular Sciences doi: 10.3390/ijms19010240

Authors: Jun Yang Adrian Harris Andrew Davidoff

Hormones play an important role in pathophysiology. The hormone receptors, such as estrogen receptor alpha and androgen receptor in breast cancer and prostate cancer, are critical to cancer cell proliferation and tumor growth. In this review we focused on the cross-talk between hormone and hypoxia pathways, particularly in breast cancer. We delineated a novel signaling pathway from estrogen receptor to hypoxia-inducible factor 1, and discussed the role of this pathway in endocrine therapy resistance. Further, we discussed the estrogen and hypoxia pathways converging at histone demethylase KDM4B, an important epigenetic modifier in cancer.

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