Forms and functions of store-operated calcium entry mediators, STIM and Orai

Publication date: Available online 22 November 2017
Source:Advances in Biological Regulation
Author(s): James W. Putney
Calcium signals arise by multiple mechanisms, including mechanisms of release of intracellular stored Ca²⁺, and the influx of Ca²⁺ through channels in the plasma membrane. One mechanism that links these two sources of Ca²⁺ is store-operated Ca²⁺ entry, the most commonly encountered version of which involves the extensively studied calcium-release-activated Ca²⁺ (CRAC) channel. The minimal and essential molecular components of the CRAC channel are the STIM proteins that function as Ca²⁺ sensors in the endoplasmic reticulum, and the Orai proteins that comprise the pore forming subunits of the CRAC channel. CRAC channels are known to play significant roles in a wide variety of physiological functions. This review discusses the multiple forms of STIM and Orai proteins encountered in mammalian cells, and discusses some specific examples of how these proteins modulate or mediate important physiological processes.



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