IJMS, Vol. 18, Pages 2479: Ergostane-Type Sterols from King Trumpet Mushroom (Pleurotus eryngii) and Their Inhibitory Effects on Aromatase

IJMS, Vol. 18, Pages 2479: Ergostane-Type Sterols from King Trumpet Mushroom (Pleurotus eryngii) and Their Inhibitory Effects on Aromatase

International Journal of Molecular Sciences doi: 10.3390/ijms18112479

Authors:Takashi KikuchiNaoki MotoyashikiTakeshi YamadaKanae ShibataniKiyofumi NinomiyaToshio MorikawaReiko Tanaka

Two new ergostane-type sterols; (22E)-5α,6α-epoxyergosta-8,14,22-triene-3β,7β-diol (1) and 5α,6α-epoxyergost-8(14)-ene-3β,7α-diol (2) were isolated from the fruiting bodies of king trumpet mushroom (Pleurotus eryngii), along with eight known compounds (3–10). All isolated compounds were evaluated for their inhibitory effects on aromatase. Among them, 4 and 6 exhibited comparable aromatase inhibitory activities to aminoglutethimide.

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