Heterogeneity of longitudinal and circumferential contraction in relation to late gadolinium enhancement in hypertrophic cardiomyopathy patients with preserved left ventricular ejection fraction

Abstract

Purpose

To evaluate heterogeneity of myocardial contraction in relation to extensive late gadolinium enhancement (LGE) in hypertrophic cardiomyopathy (HCM) patients with preserved left ventricular ejection fraction, using fast strain-encoded magnetic resonance imaging.

Materials and methods

Twenty-two HCM patients and 24 age-matched control subjects were included in this retrospective study. The regional and global peak values of longitudinal and circumferential strain (LS_regional, LS_global, CS_regional, CS_global), and their regional heterogeneities were evaluated using coefficients of variation (LS_CoV, CS_CoV) in relation to LGE. Receiver operating characteristic curve analysis was performed to identify patients with a total left ventricular myocardial LGE ≥ 15%.

Results

LS_global in HCM patients was significantly decreased compared to that in controls (− 14.4 ± 2.4% vs − 17.2 ± 2.0%; p = 0.0004), while CS_global was not (p = 1.0). Negative LGE segments demonstrated decreased LS_regional in HCM patients compared to in controls (p < 0.0001), while CS_regional was not decreased. CS_CoV demonstrated the largest area under the curve (AUC) (0.91), with high sensitivity (83%) and specificity (94%) for detection of HCM patients with extensive LGE, while the AUC of LS_CoV was low (0.49).

Conclusion

The heterogeneity in CS_regional has a high diagnostic value for detection of HCM patients with extensive LGE.

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