Source:Radiotherapy and Oncology
Author(s): Ronald Chow, Keyue Ding, Vithusha Ganesh, Ralph M. Meyer, Yvette M. van der Linden, Daniel Roos, William F. Hartsell, Peter Hoskin, Jackson S.Y. Wu, Abdenour Nabid, Manouk van Acht, Rinus Wanders, Scott Babington, William F. Demas, Carolyn F. Wilson, Rebecca K.S. Wong, Michael Brundage, Liting Zhu, Edward Chow
Background and purposePatient's gender and age may influence physicians in prescribing palliative radiotherapy. The purpose of this secondary analysis of the National Cancer Institute of Canada Clinical Trials Group Symptom Control Trial SC.20 was to explore the gender and age differences in pain and patient reported outcomes in cancer patients with bone metastases undergoing re-irradiation.Materials and methodsResponse to radiation was evaluated using the International Bone Metastases Consensus Endpoint Definitions. Patients completed the Brief Pain Inventory (BPI) and European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (C30) before and 2 months after re-irradiation.ResultsA total of 847 patients were analyzed. At baseline, men had more dyspnea, and mild pain. Older patients consumed less analgesic. More women reported clinically significant improvement in mood and enjoyment of life in the BPI after radiation. Similarly, younger patients reported better improvement in enjoyment of life. There were no significant gender or age differences in overall survival, response to radiation, or in C30 scores at 2 months.ConclusionSimilar benefit in terms of pain relief was observed across all patient groups. Cancer patients with bone metastases should be offered palliative re-irradiation irrespective of gender or age.Trial Registration: NCT00080912; http://ift.tt/2hL93EO.
from Imaging via alkiviadis.1961 on Inoreader http://ift.tt/2AdyBkS
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