Publication date: Available online 3 November 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Konstantinos I. Tosios, Eleni-Marina Kalogirou, Alexandra Sklavounou
ObjectiveTo describe four patients with oral mucosa hyperpigmentation associated with four drug classes and review the literature.Study DesignTwo patients under imatinib and hydroxychloroquine treatment exhibited diffuse palatal hyperpigmentation, while two patients medicated with minocycline and golimumab showed multifocal pigmented macules. In all cases biopsies were performed.ResultsMicroscopically, in all cases there was no increase in the number of melanocytes in the epithelium and pigment granules were present in the lamina propria. The pigment granules in minocycline- and golimumab-associated hyperpigmentation were seen in the superficial lamina propria and reacted for silver but not iron, while in imatinib- and hydroxychloroquine-associated hyperpigmentation were found in the reticular lamina propria and reacted both for silver and iron. A review of the literature found 38 cases of oral mucosa hyperpigmentation attributed to minocycline, 23 to imatinib, one to hydroxychloroquine without microscopic documentation, and none to golimumab.ConclusionThe temporal relationship between pigmentation and drug onset, resolution following drug withdrawal and exclusion of other causes support the diagnosis of drug-induced hyperpigmentation. Microscopic examination may be contributory to diagnosis, as there are differences among drugs in the distribution of pigment granules and their histochemical reactions.
from Imaging via alkiviadis.1961 on Inoreader http://ift.tt/2h2gFC1
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Publication date: Available online 4 January 2018 Source: European Journal of Radiology Author(s): Peiyao Zhang, Jing Wang, Qin Xu, Zhen...
-
Publication date: March 2017 Source: Free Radical Biology and Medicine, Volume 104 from #AlexandrosSfakianakis via Alexandros G.Sfak...
-
Dtsch med Wochenschr DOI: 10.1055/s-0043-100054 Hintergrund und Fragestellung Ein etablierter Weg, die optimale Behandlung von Tumorpatien...
-
Background Hyperthyroidism is associated with increased thrombotic risk. As contact system activation through formation of neutrophil extrac...
-
Deepak Thapa, Vanita Ahuja, Deepanshu Dhiman Indian Journal of Anaesthesia 2017 61(12):1012-1014 from #AlexandrosSfakianakis via Alexa...
-
BACKGROUND AND PURPOSE: Dengue is a common arboviral disease, which uncommonly involves the brain. There has been a recent surge in dengu...
-
Abstract Limited memory size is considered as a major bottleneck in data centers for intelligent urban computing. It is shown that there e...
-
Abstract Objective Functional magnetic resonance imaging (fMRI) is one of the most advanced techniques to analyze the cerebral effects o...
-
Vol.36 No.6 from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1k8FKtW via IFTTT
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου