JCM, Vol. 6, Pages 74: The Role of Th17 Cells in the Pathogenesis of Behcet’s Disease

JCM, Vol. 6, Pages 74: The Role of Th17 Cells in the Pathogenesis of Behcet’s Disease

Journal of Clinical Medicine doi: 10.3390/jcm6070074

Authors: Yuki Nanke Toru Yago Shigeru Kotake

Behcet’s disease (BD) is a polysymptomatic and recurrent systemic vasculitis with a chronic course and unknown cause. The pathogenesis of BD has not been fully elucidated; however, BD has been considered to be a typical Th1-mediated inflammatory disease, characterized by elevated levels of Th1 cytokines such as IFN-γ, IL-2, and TNF-α. Recently, some studies reported that Th17-associated cytokines were increased in BD; thus, Th17 cells and the IL17/IL23 pathway may play important roles in the pathogenesis of BD. In this chapter, we focus on the pathogenic role of Th17 cells in BD.

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