The Effects of Melatonin on Elevated Liver Enzymes during Statin Treatment

Taking statins can cause increase in the level of aspartate and alanine aminotransferase. The aim of this study was to assess the usefulness of melatonin in counteracting the adverse hepatic events from statins. Methods. The research program included 60 patients (aged 47–65 years, 41 women and 19 men) with hyperlipidemia taking atorvastatin or rosuvastatin at a dose of 20–40 mg daily. The patients were randomly allocated in two groups. Group I () was recommended to take the same statin at a standardized daily dose of 20 mg together with melatonin at a dose of  mg. Group II () patients took statin with placebo at the same dose and time of the day. Follow-up laboratory tests (AST, ALT, GGT, and ALP) were evaluated after 2, 4, and 6 months of treatment. Results. In Group I the levels of all enzymes decreased after 6 months, particularly AST,  U/L versus  U/L (); ALT,  U/L versus  U/L (); and GGT,  U/L versus 59,6 U/L (). Conclusion. Melatonin exerts a hepatoprotective effect in patients taking statins.

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