The flow of intracellular calcium (Ca2+) is critical for the activation and regulation of important biological events that are required in living organisms. As the major Ca2+ repositories inside the cell, the endoplasmic reticulum (ER) and the sarcoplasmic reticulum (SR) of muscle cells are central in maintaining and amplifying the intracellular Ca2+ signal. The morphology of these organelles, along with the distribution of key calcium-binding proteins (CaBPs), regulatory proteins, pumps, and receptors fundamentally impact the local and global differences in Ca2+ release kinetics. In this review, we will discuss the structural and morphological differences between the ER and SR and how they influence localized Ca2+ release, related diseases, and the need for targeted genetically encoded calcium indicators (GECIs) to study these events.
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2puK2yJ
via IFTTT
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Publication date: Available online 4 January 2018 Source: European Journal of Radiology Author(s): Peiyao Zhang, Jing Wang, Qin Xu, Zhen...
-
Abstract Hepatitis B virus (HBV) infection is a major public health problem worldwide and the major cause of hepatocellular carcinoma (HCC)...
-
Persuasive speech ideas - 50+ provoking, fresh ideas to help you find the persuasive speech topic best suited to you and your audience. fr...
-
Abstract Purpose Pedicle screw malplacement, leading to neurological symptoms, vascular injury, and premature implant loosening, is not ...
-
A comparison of the academic performance and intelligence scores of asthmatic and nonasthmatic primary... A comparison of the academic perfo...
-
Publication date: Available online 10 February 2017 Source: Brachytherapy Author(s): M.F. Jamaluddin, S. Ghosh, M.P. Waine, M. Tavakoli, J...
-
Abstract Background Tracheoesophageal puncture is an effective and reliable method for voice restoration after total laryngectomy that m...
-
Abstract In humans, thirst tends to be alleviated before complete rehydration is achieved. When sweating rates are high and ad libitum flui...
-
The area-perimeter allometric scaling is an important approach for researching fractal cities, and the basic ideas and models have been rese...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου