Evaluating the genomic yield of a single endobronchial ultrasound-guided transbronchial needle aspiration in lung cancer: meeting the challenge of doing more with less

The minimum quantity of material obtained by needle-based techniques to perform genetic profiling of lung cancer remains unclear. We show that a single endobronchial ultrasound-guided needle aspiration yields sufficient DNA to support genetic analysis with high diagnostic accuracy for clinically important mutations. This has significant implications for procedural performance in lung cancer cases where genetic alterations are highly suspected.

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