Understanding the role of the gut ecosystem in Diabetes Mellitus.

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Understanding the role of the gut ecosystem in Diabetes Mellitus.

J Diabetes Investig. 2017 Apr 08;:

Authors: Aw W, Fukuda S

Abstract
Diabetes mellitus is a type of metabolic disorder patients are unable to regulate glycemia. It is currently worldwide public health issue and is a burden to society due to its disabling and common complications. Diabetes is multi-factorial and also induces the onset of other diseases. In this report, we will review the labyrinth encompassing the gut microbiota and gut microbiota derived metabolites on type 1 diabetes and type 2 diabetes pathogenesis. There has been exceptional improvements in Deoxyribonucleic acid (DNA) sequencing and mass spectrometry technologies throughout these years and this has allowed the comprehensive collection of information on our unique gut ecosystem. We would like to advocate incorporating metagenome and metabolome information for comprehensive perspective of the complex interrelationships between the gut environment, host metabolism and diabetes pathogenesis. We hope that with this improved understanding we would be able to provide exciting novel therapeutic approaches to engineer an ideal gut ecosystem for optimal health. This article is protected by copyright. All rights reserved.

PMID: 28390093 [PubMed - as supplied by publisher]

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