Sleep Phase Delay in Cystic Fibrosis: A Potential New Manifestation of Cystic Fibrosis Transmembrane Regulator Dysfunction

Background

Cystic fibrosis (CF) transmembrane regulator (CFTR) protein dysfunction causes CF. Improving survival allows detection of increasingly subtle disease manifestations. CFTR dysfunction in the central nervous system (CNS) may disturb circadian rhythm and thus sleep phase. We studied sleep in adults to better understand potential CNS CFTR dysfunction.

Methods

We recruited participants from April 2012 through April 2015 and administered the Munich Chronotype Questionnaire (MCTQ). We compared free-day sleep measurements between CF and non-CF participants and investigated associations with CF survival predictors.

Results

We recruited 23 female and 22 male adults with CF aged 18-46 years and 26 female and 22 male volunteers aged 18-45 years. Compared to non-CF volunteers, patients with CF had delayed sleep-onset (0.612 hrs, P = 0.015), mid-sleep (1.11 hrs, P Conclusion

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