First experimental comparison between the Cartesian and the Lissajous trajectory for magnetic particle imaging

Magnetic particle imaging (MPI) is a quantitative imaging modality that allows us to determine the distribution of superparamagnetic nanoparticles. Sampling is achieved by moving a field-free point (FFP) along a specific trajectory through the volume of interest. The magnetic material that lies along the path or in the close vicinity of the FFP changes its magnetization and induces a voltage in the surrounding receiver coils. Various trajectories for the FFP are conceivable, but most experimental MPI scanners either use a Cartesian or a Lissajous sampling trajectory. For the first time, this study compares both sampling methods experimentally using an MPI scanner that allows us to implement both sampling patterns. By default, the scanner is capable of scanning 2D and 3D field of views using a Lissajous trajectory. But since it also has a 1D mode, it is possible to perform Cartesian measurements by shifting the 1D scan line in a perpendicular direction to the FFP movement using t...

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