The Upsides and Downsides of Organelle Interconnectivity

Publication date: 23 March 2017
Source:Cell, Volume 169, Issue 1
Author(s): Daniel E. Gottschling, Thomas Nyström
Interconnectivity and feedback control are hallmarks of biological systems. This includes communication between organelles, which allows them to function and adapt to changing cellular environments. While the specific mechanisms for all communications remain opaque, unraveling the wiring of organelle networks is critical to understand how biological systems are built and why they might collapse, as occurs in aging. A comprehensive understanding of all the routes involved in inter-organelle communication is still lacking, but important themes are beginning to emerge, primarily in budding yeast. These routes are reviewed here in the context of sub-system proteostasis and complex adaptive systems theory.

Teaser

The communication between cellular organelles is important for basic cellular function. Mapping the wiring between organelle networks can reveal how and when a collapse in communication may occur, such as aging.


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