Factors Predicting Renal Function Outcome after Augmentation Cystoplasty

We determined the cause of renal deterioration after augmentation cystoplasty (AC). Twenty-nine adult patients with refractory bladder dysfunction and who underwent ileocystoplasty from 2004 to 2015 were studied. Patients with a decline in glomerular filtration rate (GFR) after augmentation were reviewed. The primary outcome was to determine the factors that might lead to deterioration of estimated GFR. Median follow-up was years. Significant bladder capacity, end filling pressure, and bladder compliance were achieved from median to  ml (), to  cm H2O (), and to (), respectively. Renal function remained stable and improved in 22 () patients from median eGFR to  ml/min/1.73 m2 (). Significant deterioration was found in 7 () patients from median eGFR to (). The causes of renal deterioration were noncompliance to self-catheterization (2 patients), posterior urethral valve/dysplastic kidneys (2 patients), and reflux/infection (2 patients). On multivariate analysis, recurrent pyelonephritis (OR 3.87, ) and noncompliance (OR 30.78, ) were significant. We concluded that AC is not the cause of progression to end-stage renal disease in patients with renal insufficiency.

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