Τρίτη 28 Μαρτίου 2017

Exhaustion-associated regulatory regions in CD8+ tumor-infiltrating T cells [Immunology and Inflammation]

T-cell exhaustion is a progressive loss of effector function and memory potential due to persistent antigen exposure, which occurs in chronic viral infections and cancer. Here we investigate the relation between gene expression and chromatin accessibility in CD8+ tumor-infiltrating lymphocytes (TILs) that recognize a model tumor antigen and have features...

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