Henderson and colleagues have misinterpreted our Comment1 and the totality of evidence on which it is based. The issue is not whether or not dietary guidelines are beyond criticism but rather whether the criticisms are justified. A substantial body of observational, clinical trial, and experimental evidence summarised in our Comment support the recommendation to reduce total saturated fatty acids and that they might be replaced with unsaturated vegetable oils. Suggestions that some sources of saturated fatty acids might not be associated with adverse health outcomes and that some trans unsaturated fatty acids could be associated with reduced diabetes risk should be a stimulus for further research to enable dietary guidelines to be refined in the future.
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