The role of changes in maximum standardized uptake value of FDG PET-CT for post-treatment surveillance in patients with head and neck squamous cell carcinoma treated with chemoradiotherapy: Preliminary findings.

The role of changes in maximum standardized uptake value of FDG PET-CT for post-treatment surveillance in patients with head and neck squamous cell carcinoma treated with chemoradiotherapy: Preliminary findings.

Br J Radiol. 2017 Jan 05;:20150404

Authors: Matoba M, Tuji H, Shimode Y, Kondo T, Oota K, Tonami H

Abstract
OBJECTIVE: No clear consensus exists regarding the optimal interval and frequency of follow-up PET-CT in head and neck squamous cell carcinoma (HNSCC) patients treated with chemoradiotherapy (CRT). Here we sought to clarify whether the changes in the maximum standardized uptake value (ΔSUVmax) may be a valid parameter to help decision-making for surveillance management after CRT.
METHODS: Forty patients underwent PET-CT at pretreatment and 3 months after CRT. Patients were followed by sequential PET-CT for 2 years after CRT. The ΔSUVmax of the primary tumour and the metastatic nodes were calculated between pretreatment and 3 months after the CRT, and we evaluated the associations between ΔSUVmax and the manifestation of recurrence, time to recurrence, and the patients' survival.
RESULTS: The ΔSUVmax of the primary tumour was significantly lower for the lesions with recurrence compared to those with nonrecurrence for both the primary site and the nodal site (p=0.007, 0.02). A significant correlation was found between the time to recurrence and the ΔSUVmax of the primary tumour (r=0.63, p<0.05). The threshold ΔSUVmax of the primary tumour of 1.04 revealed 76.9% sensitivity and 86.4% specificity for distinguishing recurrence from nonrecurrence. The progression-free survival and overall survival of the two patients groups divided by the ΔSUVmax of the primary tumour at 1.04 showed a significant difference (p=0.003, 0.02). The ΔSUVmax of the metastatic nodes did not show a significant association with recurrence or patient survival.
CONCLUSION: The ΔSUVmax of the primary tumour showed a significant association with recurrence and patient survival. Advances in knowledge: The ΔSUVmax of the primary tumour may be a valid clinical parameter to help decision-making for the surveillance management of HNSCC patients after CRT.

PMID: 28055245 [PubMed - as supplied by publisher]

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