The relationship between serum visfatin and the progress of chronic viral hepatitis B cirrhosis

OBJECTIVE: To explore the relationship between serum visfatin and the progress of chronic viral hepatitis B cirrhosis.

PATIENTS AND METHODS: Selected 153 cases of chronic hepatitis B patients with cirrhosis as an observational group. Among which, Child-Pugh Grade was divided into grade A with 31 cases, grade B with 79 cases and grade C with 43 cases. 50 healthy people were added to the study and were considered as control group. Comparison of the sera levels of visfatin, blood lipid, liver fibrosis indexes, fasting plasma glucose and fasting insulin of the observational and those of the control group were done.

RESULTS: Levels of visfatin, hyaluronic acid (HA), laminin (LN), type IV collagen (CIV) and insulin resistance index (HOMA-IR) were significantly increased (p<0.05) while those of the liver function damage aggravating in observational group. The differences were of no statistical significance for the levels of triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), fasting plasma glucose (FBG) and fasting insulin level (Fins) (p<0.05).

CONCLUSIONS: The increase of the levels of serum visfatin of chronic hepatitis B patients with cirrhosis is related to liver cirrhosis progress, indicators of hepatic fibrosis and HOMA-IR.

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