This year will see major changes in leadership at WHO and at the Global Fund to Fight AIDS, Tuberculosis and Malaria, and probably in some other health-related multilateral organisations as well. History has shown that an able leader at the helm can make a difference. However, governance, organisational culture and performance, and funding equally define a leader's effectiveness. In the case of multilateral institutions, these are complex matters given the conflicting interests of their multiple stakeholders.
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