Recent years have witnessed considerable advancement in the understanding of mast cell (MC) development and function in health and disease. MCs arise from CD34+ bone marrow–derived progenitors, but unlike other hematopoietic cells, they are not released to the blood circulation in a mature state.1 Rather, MC precursors home to peripheral tissues, where they reach full differentiation after birth under the influence of the local microenvironment. At this stage, they express the high-affinity IgE receptor FcεRI, along with the stem cell factor (SCF) receptor c-Kit, which is a critical determinant in their maturation, proliferation, and survival.
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