A crucial factor in maintaining genome stability is establishing deoxynucleoside triphosphate (dNTP) levels within a range that is optimal for chromosomal replication. Since DNA replication is relevant to a wide range of other chromosomal activities, these may all be directly or indirectly affected when dNTP concentrations deviate from a physiologically normal range. The importance of understanding these consequences is relevant to genetic disorders that disturb dNTP levels, and strategies that inhibit dNTP synthesis in cancer chemotherapy and for treatment of other disorders. We review here how abnormal dNTP levels affect DNA replication and discuss the consequences for genome stability.
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2jy8o7P
via IFTTT
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Abstract We present an analytic study to support the understanding of collapsing of glass tubes released by local heating and driven by th...
-
The San Diego Union-Tribune Scientists move closer to detecting cancer long before any symptoms appear The San Diego Union-Tribune T...
-
Abstract Software defined network (SDN) is a very popular notion and has drawn much attention from academia. In this study, we propose an ...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου