Endoplasmic reticulum-mitochondria Ca2+ crosstalk in the control of the tumor cell fate

Publication date: Available online 4 January 2017
Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Author(s): Sonia Missiroli, Alberto Danese, Tommaso Iannitti, Simone Patergnani, Mariasole Perrone, Maurizio Previati, Carlotta Giorgi, Paolo Pinton
Mitochondria-associated membranes are juxtaposed between the endoplasmic reticulum and mitochondria and have been identified as a critical hub in the regulation of apoptosis and tumor growth. One key function of mitochondria-associated membranes is to provide asylum to a number of proteins with tumor suppressor and oncogenic properties. In this review, we discuss how Ca²⁺ flux manipulation represents the primary mechanism underlying the action of several oncogenes and tumor-suppressor genes and how these networks might be manipulated to provide novel therapies for cancer. This article is part of a Special Issue entitled: ECS Meeting edited by Claus Heizmann, Joachim Krebs and Jacques Haiech.



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