Association between environmental tobacco smoke exposure and the occurrence of EGFR mutations and ALK-rearrangements in never-smokers with non-small cell lung cancer: analyses from a prospective multinational ETS registry

Environmental tobacco smoke (ETS) is a potential cause of driver gene alterations. Using an extended multinational cohort of 498 never-smoker patients with non-small cell lung cancer (NSCLC), the authors show higher incidence of EGFR mutations in patients with ETS exposure compared with those with no ETS exposure, significant associations of increasing ETS exposure and EGFR mutation frequency in female but not male gender, and no correlation of ETS exposure and ALK rearrangements.

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