Alterations in prefrontal cortex (PFC) function and abnormalities in its interactions with other brain areas (i.e., the hippocampus) have been related to Alzheimer Disease (AD). Considering that these malfunctions correlate with the increase in the brain’s amyloid beta (Aβ) peptide production, here we looked for a causal relationship between these pathognomonic signs of AD. Thus, we tested whether or not Aβ affects the activity of the PFC network and the activation of this cortex by hippocampal input stimulation in vitro. We found that Aβ application to brain slices inhibits PFC spontaneous network activity as well as PFC activation, both at the population and at the single-cell level, when the hippocampal input is stimulated. Our data suggest that Aβ can contribute to AD by disrupting PFC activity and its long-range interactions throughout the brain.
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2hMxXFZ
via IFTTT
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Publication date: Available online 4 January 2018 Source: European Journal of Radiology Author(s): Peiyao Zhang, Jing Wang, Qin Xu, Zhen...
-
Consulting to Finance: How to Network, Tell Your Story, Spin Your Resume, and Dominate Your Investment Banking and Private Equity Interviews...
-
Abstract Purpose Pedicle screw malplacement, leading to neurological symptoms, vascular injury, and premature implant loosening, is not ...
-
Chromatin-based mechanisms offer therapeutic targets in acute myeloid leukemia (AML) that are of great current interest. In this study, we c...
-
A comparison of the academic performance and intelligence scores of asthmatic and nonasthmatic primary... A comparison of the academic perfo...
-
Publication date: Available online 10 February 2017 Source: Brachytherapy Author(s): M.F. Jamaluddin, S. Ghosh, M.P. Waine, M. Tavakoli, J...
-
Abstract Background Tracheoesophageal puncture is an effective and reliable method for voice restoration after total laryngectomy that m...
-
The Future of Pediatric Obesity. Prim Care. 2016 Mar;43(1):1-17 Authors: Hutchinson J, Emerick J, Saxena H Abstract The National He...
-
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2zeMqlg via IFTTT
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου