Pemphigus Vulgaris: A Comprehensive Presentation of the Desmosomal Adhesion Disrupting and Oral Blister Causing Multifactorial Autoimmune Disease

2016-12-07T17-58-25Z
Source: Journal of Experimental and Integrative Medicine
Mandy Alhajj, Sathees B Chandra.
Abstract: Pemphigus Vulgaris (PV) is a blister causing autoimmune disease that is continually being studied because of its devastating symptomology and life-threatening effects on patients afflicted with the disease. There is a sense of urgency in finding better treatment options for PV patients and an even greater emphasis placed on diagnosing the disease in its earliest stages in order to improve its prognosis. The purpose of this paper is to provide a thorough presentation of pemphigus vulgaris, by discussing its genetics, prevalence, physiological mechanisms, pathogenesis, diagnostic and monitoring techniques, and treatments, in order to better equip clinicians with the current information on the disease and to prompt interest in future research on identifying potential environmental triggers.


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