2016-11-08T01-11-23Z
Source: Indo American Journal of Pharmaceutical Research
Abdulkareem Ali Hussein,*, Bushra Ahmed Kateb,, P.A. Kulkarni.
In the present study, a novel series of N-acetyl pyrazolines (4a-j) were synthesized from different chalcones (3a-j) with hydrazine hydrate and glacial acetic acid. The compounds were synthesized and characterizes by TLC, melting points, IR, and 1H-NMR spectra. All the synthesized compounds have been screened and evaluated for antibacterial activity against Staphylococcus aureus gr +ve, Escherichia coli gr ve, Bacillus subtilis gr +ve, Salmonella typhi gr ve , and antifungal activity against Aspergillus oryzoe, Aspergillus niger, using disc diffusion method. The compounds show the moderate to good activity against bacteria. The new structural classes of compounds may prove as lead molecules and good candidates for the future investigations.
http://ift.tt/2fyRPIS
Τρίτη 8 Νοεμβρίου 2016
SYNTHESIS AND ANTIMICROBIAL SCREENING OF SOME NEW N-ACETYL PYRAZOLINES FROM SUBSTITUTED CHALCONES
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