2016-09-29T05-30-58Z
Source: Journal of Applied Pharmaceutical Science
Surendra Tripathy, Brijesh Kumar Singh, Dilip Kumar Patel, Narahari Narayan Palei.
The major drawback of Simvastatin to formulate a dosage form is its poor aqueous solubility. In this study a solvent and carrier less technique called Melt sonocrystallization was utilized to form tiny crystals of Simvaststin with enhanced solubility in distilled water and Phosphate buffer pH 7.4, with an insignificant (p > 0.05) change in partition behaviour. The Melt sonocrystallized Simvaststin (MSCSIM) was characterized by FT-IR, DSC and SEM. The flow property was characterized and compared with pure Simvastatin. The MSCSIM was incorporated in directly compressed matrix tablets formed with varying proportion of HPMC K100 LV and starch. The formed tablets were evaluated for pharmacotechnical parameters along with drug release study. After melt sonocrystallization the chemical integrity of drug was unchanged and showed a sound flow property. The pharmacotechnical features of the tablets were noted to be within pharmacopoeial limit. The formulation F5 displayed a comparatively more controlled release of drug (96.45%) over 12 hours. The major release mechanism was found to be anomalous diffusion, with n value of 0.58 from the Korsmeyer-Peppas model, suggesting the drug release driven by swelling of matrix and diffusion. This technique may prove to be beneficial for poorly water soluble drugs and the melt sonocrystallized drugs can lend themselves for developing controlled release formulations.
http://ift.tt/2cDTN7a
Πέμπτη 29 Σεπτεμβρίου 2016
Hydrophilic Matrix Based Oral Controlled Release Tablets of Melt Sonocrystallized Simvastatin
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Publication date: Available online 4 January 2018 Source: European Journal of Radiology Author(s): Peiyao Zhang, Jing Wang, Qin Xu, Zhen...
-
Background Hyperthyroidism is associated with increased thrombotic risk. As contact system activation through formation of neutrophil extrac...
-
Dtsch med Wochenschr DOI: 10.1055/s-0043-100054 Hintergrund und Fragestellung Ein etablierter Weg, die optimale Behandlung von Tumorpatien...
-
Publication date: March 2017 Source: Free Radical Biology and Medicine, Volume 104 from #AlexandrosSfakianakis via Alexandros G.Sfak...
-
Related Articles Anatomic parameters of the sacral lamina for osteosynthesis in transverse sacral fractures. Surg Radiol Anat....
-
Medicine by Alexandros G. Sfakianakis,Anapafseos 5... Medicine by Alexandros G. Sfakianakis,Anapafseos 5... Heralding change: The evolution ...
-
BACKGROUND AND PURPOSE: Dengue is a common arboviral disease, which uncommonly involves the brain. There has been a recent surge in dengu...
-
Purpose. We present a case of a patient with Soemmering ring after cataract surgery and a potential complication that can arise as a result ...
-
Abstract Purpose Investigate in patients with metastatic and/or irresectable colorectal cancer treated with systemic treatment with cape...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου