2016-09-26T04-35-55Z
Source: Indo American Journal of Pharmaceutical Research
Godiyal Shilpa*, Nihalani Girish, Qureshi Rizwan, Jadhav Kisan, Kadam Vilasrao.
A simple, economic, accurate, rapid high performance thin-layer chromatography method has been developed and validated for quantitative estimation of valsartan in bulk and from marketed formulation. The chromatographic separation was carried out on Silica Gel 60 F254 precoated TLC plates using toluene: ethanol: glacial acetic acid (7:3:0.01 v/v) as mobile phase. Detection was carried out densitometrically using UV detector at 251 nm. This system was found to give separation for valsartan with Rf 0.56. The calibration curve was found to be linear between 50 300 ng/spot for valsartan with significantly high value of correlation coefficient (r2 = 0.9926). The limits of detection and quantitation were found to be 1.8548 and 5.6206 ng/spot for valsartan. The accuracy was determined by percentage recovery and was found to be 99.41% for valsartan. The developed HPTLC method was validated as per recommendations given by ICH guidelines Q2 (R1). The developed method was found to be specific, reproducible, selective for estimation of valsartan from bulk and its marketed formulation.
http://ift.tt/2ddAJB1
Δευτέρα 26 Σεπτεμβρίου 2016
DEVELOPMENT AND VALIDATION OF HPTLC METHOD FOR ESTIMATION OF VALSARTAN IN BULK AND MARKETED FORMULATION
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