DOCK8-Deficient CD4+ T Cells are Biased to a Th2 Effector Fate at the Expense of Th1 and Th17 Cells

DOCK8-deficient CD4+ T cells exhibit dysregulated cytokine responses, with exaggerated production of Th2 cytokines, and impaired production of Th1 and Th17 cytokines. Collectively these findings provide explanations for some of the clinical features of DOCK8 deficiency, such as eczema and food allergies, and recurrent viral and microbial infections.

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