2016-10-16T06-25-49Z
Source: Indo American Journal of Pharmaceutical Research
Bushra Ahmed Kateb,, Abdulkareem Ali Hussien-, M. A. Basser*.
We applied simple and convenient procedure for the synthesis of optically active1,5- benzothiazepine derivatives by reaction of 2-aminothiophenol with newly synthesized Chalcones under mild conditions in the presence of catalytic amount of Lanthanum Nitrate in short reaction time with excellent yield(75-85%). The compounds (4a-l) were tested for purity by TLC and characterized by M.P, IR and 1H NMR and Mass spectral studies. The synthesized compounds have been screened for antibacterial activity against Staphylococcus aureus gram +ve, Escherichia coli gram ve Bacillus subtilis gram +ve, Salmonella typhi gram ve, and antifungal activity against Aspergillus oryzoe, Aspergillus niger, using disc diffusion method. The compounds show the moderate to good activity against bacteria and fungui.
http://ift.tt/2eelMRv
Κυριακή 16 Οκτωβρίου 2016
SYNTHESIS, AND ANTIMICROBIAL ACTIVITY OF NEW 1, 5-BENZOTHIAZEPINES USING LANTHANUM NITRATE AS A CATALYST
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