Παρασκευή 2 Σεπτεμβρίου 2016
Redesign of the GATE PET coincidence sorter
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Non-local total-variation (NLTV) minimization combined with reweighted L1-norm for compressed sensing CT reconstruction
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Motion-aware temporal regularization for improved 4D cone-beam computed tomography
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How a young maverick’s grit saved the world’s rarest bird
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IJMS, Vol. 17, Pages 1467: Aberrant JAK/STAT Signaling Suppresses TFF1 and TFF2 through Epigenetic Silencing of GATA6 in Gastric Cancer
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IJMS, Vol. 17, Pages 1469: Advances in Integrating Traditional and Omic Biomarkers When Analyzing the Effects of the Mediterranean Diet Intervention in Cardiovascular Prevention
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IJMS, Vol. 17, Pages 1427: MicroRNA-378 Alleviates Cerebral Ischemic Injury by Negatively Regulating Apoptosis Executioner Caspase-3
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IJMS, Vol. 17, Pages 1465: Restoration of Immune Responsiveness to Glioma by Vaccination of Mice with Established Brain Gliomas with a Semi-Allogeneic Vaccine
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IJMS, Vol. 17, Pages 1470: Cannibalism Affects Core Metabolic Processes in Helicoverpa armigera Larvae—A 2D NMR Metabolomics Study
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IJMS, Vol. 17, Pages 1464: Infectious Diseases: Pathophysiology, Diagnostics and Prevention
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IJMS, Vol. 17, Pages 1466: Preparation of Silk Sericin/Lignin Blend Beads for the Removal of Hexavalent Chromium Ions
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IJMS, Vol. 17, Pages 1463: Perillyl Alcohol and Its Drug-Conjugated Derivatives as Potential Novel Methods of Treating Brain Metastases
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IJMS, Vol. 17, Pages 1468: Melanoma Brain Metastasis: Mechanisms, Models, and Medicine
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IJERPH, Vol. 13, Pages 879: Atherogenic Index of Plasma Predicts Hyperuricemia in Rural Population: A Cross-Sectional Study from Northeast China
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IJERPH, Vol. 13, Pages 880: Neighborhood Landscape Spatial Patterns and Land Surface Temperature: An Empirical Study on Single-Family Residential Areas in Austin, Texas
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IJERPH, Vol. 13, Pages 878: Spatial Variability of PAHs and Microbial Community Structure in Surrounding Surficial Soil of Coal-Fired Power Plants in Xuzhou, China
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Functional SNP in 3’-UTR microRNA Binding Site of ZNF350 Confers Risk for Age-Related Cataract
ABSTRACT
Many studies have suggested that individual susceptibility to age-related cataract (ARC) may be associated with DNA sequence polymorphisms affecting gene regulation. As DNA repair is implicated in ARC pathogenesis and single nucleotide polymorphisms (SNPs) in the 3’-terminal untranslated region (3’-UTR) targeted by microRNAs (miRNAs) can alter the gene function, we hypothesize that the miRNA biding SNPs (miRSNPs) in DNA double-strand break repair (DSBR) and nucleotide excision repair (NER) pathways might associate with ARC risk. We genotyped 9 miRSNPs of 8 genes in DSBR and NER pathways in Chinese population and found that ZNF350- rs2278414:G>A was significantly associated with ARC risk. Even though the Comet assay of cellular DNA damage indicated that all the subtypes of ARC patients had more DNA breaks in peripheral lymphocytes than the controls independent of rs2278414 genotypes, individuals carrying the variant A allele (AA and AG) had lower ZNF350 mRNA levels compared to individuals with GG genotype. Moreover, the in vitro experiment indicated that miR-21-3p and miR-150-5p specifically downregulated luciferase reporter expression in the cell lines transfected with rs2278414 A allele compared to rs2278414 G. These results suggested that the association of SNP rs2278414 with ARC might involve an altered miRNA regulation of ZNF350.
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Genotype–Phenotype Correlations of Malignant Hyperthermia and Central Core Disease Mutations in the Central Region of the RYR1 Channel
ABSTRACT
Type 1 ryanodine receptor (RYR1) is a Ca2+ release channel in the sarcoplasmic reticulum of skeletal muscle and is mutated in some muscle diseases, including malignant hyperthermia (MH) and central core disease (CCD). Over 200 mutations associated with these diseases have been identified, and most mutations accelerate Ca2+-induced Ca2+ release (CICR), resulting in abnormal Ca2+ homeostasis in skeletal muscle. However, it remains largely unknown how specific mutations cause different phenotypes. In this study, we investigated the CICR activity of 14 mutations at 10 different positions in the central region of RYR1 (10 MH and four MH/CCD mutations) using a heterologous expression system in HEK293 cells. In live-cell Ca2+ imaging, the mutant channels exhibited an enhanced sensitivity to caffeine, a reduced endoplasmic reticulum Ca2+ content, and an increased resting cytoplasmic Ca2+ level. The three parameters for CICR (Ca2+ sensitivity for activation, Ca2+ sensitivity for inactivation, and attainable maximum activity, i.e., gain) were obtained by [3H]ryanodine binding and fitting analysis. The mutant channels showed increased gain and Ca2+ sensitivity for activation in a site-specific manner. Genotype–phenotype correlations were explained well by the near-atomic structure of RYR1. Our data suggest that divergent CICR activity may cause various disease phenotypes by specific mutations.
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How a young maverick’s grit saved the world’s rarest bird
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News Beyond Our Pages
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Brief Overview of This Month's JACI
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News & Notes
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Table of Contents
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CME Activities Calendar
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Editorial Board
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The Editors' Choice
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Information for Readers
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Anionic surfactants and commercial detergents decrease tight junction barrier integrity in human keratinocytes
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Role of regulatory B cells in immune tolerance to allergens and beyond
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Regulatory T cells in allergic diseases
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Regulatory T cells in allergic diseases
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Creation and implementation of SAMPRO™: A school-based asthma management program
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Effect of treatment of rectal cancer metastasis with intravitreal bevacizumab (Avastin) in patient with subretinal fluid and macular oedema: short-term follow-up
We describe the management of subretinal fluid and macular oedema due to colorectal cancer metastasis to the choroid using intravitreal bevacizumab. A patient with grade VI KRAS mutation rectal cancer with metastasis to the lung and cerebellum presented with left eye choroidal metastasis 1 week after being started on the experimental medication KTN3379. After intravitreal bevacizumab administration, the patient had improvement in macular subretinal fluid, but eventually progressed to severe cystoid macular oedema despite monthly intravitreal bevacizumab treatment.
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Ethiopian-Israeli community
The Ethiopian-Jewish community in Israel is an immigrant population numbering 131 400 as of 2012. Many arrived from 1980 to 1992 by airborne operations coordinated by the Israeli government. Immigration was prompted by Israeli recognition of the community's Jewish citizenship eligibility status. This period in Israel's history saw the First Lebanon War, the First Intifada, the Gulf War and the beginning of Soviet Jewish immigration. The Ethiopian community faced difficult integration, cross-cultural misunderstandings and the development of chronic disease, due to lifestyle changes and differences in cultural beliefs. These factors significantly affect the community's health. Governmental and non-governmental organisations have sought to improve the quality of life for Ethiopian Israelis through empowerment and education. Enhancing societal integration, augmenting cross-cultural communication and understanding and instituting community-based health projects are essential in improving the health of this community. Successful healthcare intervention requires a biopsychosocial model of analysis and usage of a culturally appropriate context.
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ANCA-negative eosinophilic granulomatosis with polyangitis (EGPA) manifesting as a large intracardiac thrombus and glomerulonephritis with angionecrosis
A 59-year-old woman with a history of bronchial asthma presented with a prolonged fever and eosinophilia. There was transient proteinuria and troponin level was elevated. Antineutrophil cytoplasmic antibody was negative and she did not fulfil criteria for eosinophilic granulomatosis with polyangitis (EGPA). Echocardiography showed a large apical mass in the left ventricle, but there was no systolic dysfunction, local asynergy or ventricular remodelling. On MRI, apical mass was compatible with a thrombus and endocardial region was diffusely damaged. Loeffler endocarditis-like cardiac manifestation led to meticulous examination, which found no aetiology for eosinophilia. Finally, renal biopsy revealed eosinophil infiltration and glomerular angionecrosis, confirming as EGPA. This case highlights the isolated large cardiac thrombus as a rare presenting sign for EGPA and underscores current complicated strategy to diagnose EGPA. Of note, this clinical challenge was mostly caused by inchoate comprehension of hypereosinophilia-related disorders.
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Orolingual angioedema to alteplase. Identify, counsel and monitor at risk patients
Orolingual angioedema (OLA) is a known complication of intravenous alteplase used to treat ischaemic stroke. The incidence may be as high as 5.1%. ACE inhibitors are thought to increase the risk of developing this potentially life-threatening complication. This case report demonstrates how we may improve in the identification of risk factors in the history; the counselling of patients appropriately; in seeking alternative therapies such as mechanical thrombectomy; and in the monitoring of patients for signs of OLA once alteplase has been given.
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Penetrating cardiac injury: sustaining health by building team resilience in growing civilian violence
Penetrating cardiac injury (PCI) is gradually increasing in developing countries owing to large-scale manufacturing of illegal country-made weapons. These injuries are associated with significant morbidity and mortality. Logistically it is difficult to have all organ-based specialists arrive together and attend every critically injured patient round-the-clock in developing countries. It is therefore important for doctors (physicians, surgeons and anaesthetists) to be trained for adequate management of critically injured patients following trauma. We report the approach towards 2 cases of haemodynamically unstable PCI managed by a team of trauma doctors. Time lag (duration between injury and arrival at hospital) and quick horizontal resuscitation are important considerations in the treatment. By not referring these patients to different hospitals the team actually reduced the time lag, and a quick life-saving surgery by trauma surgeons (trained in torso surgery) offered these almost dying patients a chance of survival.
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Traumatic anterior dislocation of the hip
A 31-year-old male motorcyclist presented to the emergency department(ED) following a road traffic accident with significant right hip pain and inability to weight bear. On examination the patient had a shortened and externally rotated leg with absent peripheral pulses and cold peripheries concerning for vascular compromise. A plain radiograph demonstrated an anterior hip dislocation (AHD) with a greater trochanter (GT) fracture (figure 1). An urgent CT of the pelvis was performed to exclude the possibility of a femoral neck fracture (figure 2A, B). The hip was reduced under conscious sedation in the ED using the Allis method. The peripheral pulses returned. A further CT angiogram of the pelvis was performed which showed concentric reduction, an undisplaced GT fracture and a short segment dissection of the right external iliac artery which was managed conservatively as directed by the vascular team (figure 3A,...
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Retinoic acid suppresses colorectal cancer development, researchers say: https://t.co/4NROGcc45o
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Preparations underway for our upcoming event in Cardiff! Contact editor@ecancer .org for last-minute signup! https://t.co/nKbgKSh5rE
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RT @ecancer_espanol : Dr Adele Murrell discussed the potential influence of epigenetics on lung cancer #lungcancer16
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RT @ecancer_espanol : Dr O Pardo talked about the use of metabolomics to find novel target in Chemo-resistant lung cancer #lungcancer16 http…
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Dr Olivier Pardo discusses challenges & the future of metabolomics at #lungcancer16 https://t.co/S26V6ceOC8
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Dr Adele Murrell: 'We should ideally be looking for pre-disposition to cancer for early intervention' #lungcancer16 https://t.co/h8CvkDZstl
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People born underweight do less exercise throughout their lives
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There is now a sixth taste – and it explains why we love carbs
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Kjøtt sett i relasjon til evolusjonen
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Hvem fikk tidlig hjelp etter Utøya-angrepet?
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David Oliver: Groundhog days for doctors
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Δημοφιλείς αναρτήσεις
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Background Hyperthyroidism is associated with increased thrombotic risk. As contact system activation through formation of neutrophil extrac...
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UM-Chor1: establishment and characterization of the first validated clival chordoma cell line. J Neurosurg. 2017 Apr 21;:1-9 Authors:...
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Impact of habitat loss and fragmentation on reproduction, dispersal and species persistence for an endangered Chilean tree Abstract Survival...
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Publication date: Available online 10 May 2017 Source: Journal of Dairy Science Author(s): R.E. Vibart, M. Tavendale, D. Otter, B.H. Schw...
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Competency-based psychiatric education for Indian medical undergraduates Vijayalakshmi Pernenkil Archives of Mental Health 2019 20(1):1-2 Be...
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Related Articles Developmental control of macrophage function. Curr Opin Immunol. 2017 Dec 13;50:64-74 Authors: Bonnardel J, Guillia...
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Kajal Manchanda, Sandip Mohanty, Pallavi C Rohatgi Indian Dermatology Online Journal 2017 8(3):186-191 Introduction: Topical corticoster...
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Summary The preventive effect of coffee on cancer at different sites has been reported, although the effect on all-sites cancer incidence ...
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A mutational signature associated with alcohol consumption and prognostically significantly mutated driver genes in esophageal squamous...