Animal models of cathartic colon

paythelady.612 shared this article with you from Inoreader Animal models of cathartic colon Μέσω pubmed: "world j clin cases"... World J Clin Cases. 2021 Feb 26;9(6):1251-1258. doi: 10.12998/wjcc.v9.i6.1251. ABSTRACT The incidence of cathartic colon has been increasing, but satisfactory treatments are still lacking. In order to study the pathological mechanisms of the disorder and identify effective treatment methods, researchers have established different animal models of cathartic colon. This minireview briefly summarizes several common cathartic colon animal models, induced with anthraquinone laxatives such as rhubarb, total anthraquinone, rhein, and emodin, or induced with diphenylmethane laxatives such as phenolphthalein. The advantages and limitations of these models are evaluated and analyzed. We hope that this review will facilitate the selection of suitable models and improve relevant modeling methods. We anticipate the development of more convenient and stable models that can reflect the characteristics of cathartic colon in humans, and serve as useful tools for further studies. PMID:33644192 | PMC:PMC7896687 | DOI:10.12998/wjcc.v9.i6.1251 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Treatment of oral lichen planus by surgical excision and acellular dermal matrix grafting: Eleven case reports and review of literature

paythelady.612 shared this article with you from Inoreader Treatment of oral lichen planus by surgical excision and acellular dermal matrix grafting: Eleven case reports and review of literature Μέσω pubmed: "world j clin cases"... World J Clin Cases. 2021 Feb 26;9(6):1446-1454. doi: 10.12998/wjcc.v9.i6.1446. ABSTRACT BACKGROUND: Oral lichen planus (OLP) is a chronic inflammatory disorder, and it can affect normal oral function. The conventional treatments for OLP are not always effective, and relapse easily occurs. Therefore, treatment of OLP is difficult and challenging. In this study, we evaluated over a long period the clinical efficacy of surgical excision and acellular dermal matrix (ADM) grafting in patients with refractory OLP. CASE SUMMARY: Eleven patients with refractory OLP underwent a standardized protocol of surgical excision and ADM grafting. The condition of the area of the grafted wound, the intraoperative maximum mouth opening, pain, and clinical healing were assessed at postoperative follow-up visits. All patients had a flat surgical area with similar mucosal tissue coverage and local scar formation. Patients had no irritation and pain in their mucous membranes when eating acidic and spicy food. All patients' mouth openings returned to normal within 2-6 mo after surgery. During follow-up, none of the patients had recurrence of OLP after surgery. The longest follow-up was 11 yr and the shortest was 6 mo, and none of the patients relapsed during follow-up. CONCLUSION: Surgical excision and ADM grafting could be an effective method to treat refractory OLP. PMID:33644214 | PMC:PMC 7896670 | DOI:10.12998/wjcc.v9.i6.1446 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Gastrointestinal stromal tumor with multisegmental spinal metastases as first presentation: A case report and review of the literature

paythelady.612 shared this article with you from Inoreader Gastrointestinal stromal tumor with multisegmental spinal metastases as first presentation: A case report and review of the literature Μέσω pubmed: "world j clin cases"... World J Clin Cases. 2021 Feb 26;9(6):1490-1498. doi: 10.12998/wjcc.v9.i6.1490. ABSTRACT BACKGROUND: Gastrointestinal stromal tumor (GIST) usually originates in the stomach, followed by the small intestine, rectum, and other parts of the gastrointestinal tract. The most common sites of metastasis are the liver and peritoneum, whereas spinal metastases from GIST are extremely rare. CASE SUMMARY: We found a case of GIST with the first presentation of multilevel spinal metastases involving the thoracic and lumbar vertebrae. A 61-year-old Chinese man presented to our clinic because of pain in his lower back and hip for 10 d without cause. Subsequently, computed tomography (CT) and magnetic resonance imaging (MRI) revealed abnormal signals in the vertebral appendages of T12 and L4 accompanied by spinal canal stenosis, which was considered as tumor metastasis. As there were no metastases to vital organs, posterior thoracic and lumbar sp inal decompression + adnexal mass resection + pedicle internal fixation was adopted to achieve local cure and prevent nerve compression. The results of histopathological studies were consistent with the metastasis of GIST. No local recurrence or new metastases were found at the 6-mo follow-up at the surgical site. The patient has no neurological symptoms at present. It is worth mentioning that a rectal mass was found and surgically removed 1 mo after the patient was discharged from hospital, and the pathological diagnosis of the mass was GIST. CONCLUSION: By reviewing 26 previously reported cases of spinal metastasis in GIST, it was found that spinal metastasis of GIST has become more common in recent years, so the possibility of early spinal metastasis should be recognized. CT and MRI are of great value in the diagnosis of spinal metastatic tumors, and pathological biopsy is the gold standard for the diagnosis of metastatic tumors. It is safe and feasible to treat isolated sp inal metastasis in GIST by excising metastatic masses, decompressing the spinal canal, and stabilizing the spine. PMID:33644220 | PMC:PMC7896676 | DOI:10.12998/wjcc.v9.i6.1490 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Nonalcoholic fatty liver disease as a risk factor for cytomegalovirus hepatitis in an immunocompetent patient: A case report

paythelady.612 shared this article with you from Inoreader Nonalcoholic fatty liver disease as a risk factor for cytomegalovirus hepatitis in an immunocompetent patient: A case report Μέσω pubmed: "world j clin cases"... World J Clin Cases. 2021 Feb 26;9(6):1455-1460. doi: 10.12998/wjcc.v9.i6.1455. ABSTRACT BACKGROUND: Almost 80 percent of adults in the United States have had cytomegalovirus (CMV) infection by age 40. The number of symptomatic CMV hepatitis cases has been increasing along with non-alcoholic fatty liver disease (NAFLD) cases in the United States that is estimated to be 25 percent of the population. In this paper, we try to link these two entities together. CASE SUMMARY: In this case report, we describe a young female who presented with fever, nausea, and vomiting who was found to have NAFLD and CMV hepatitis that was treated supportively. CONCLUSION: In this case report, we describe NAFLD as a risk factor for CMV hepatitis and discuss the possible impact on clinical practice. We believe, it is essential to consider NAFLD and it's disease mechanisms' localized immu-nosuppression, as a risk factor of CMV hepatitis and severe c oronavirus disease 2019 infection. PMID:33644215 | PMC:PMC7896686 | DOI:10.12998/wjcc.v9.i6.1455 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Early reoccurrence of traumatic posterior atlantoaxial dislocation without fracture: A case report

paythelady.612 shared this article with you from Inoreader Early reoccurrence of traumatic posterior atlantoaxial dislocation without fracture: A case report Μέσω pubmed: "world j clin cases"... World J Clin Cases. 2021 Feb 26;9(6):1461-1468. doi: 10.12998/wjcc.v9.i6.1461. ABSTRACT BACKGROUND: In general, atlantoaxial dislocation is rare due to the stability of the C1-C2 complex. Traumatic atlantoaxial dislocations are usually anterior and accompanied by odontoid fractures. Posterior atlantoaxial dislocations are rare, and complete posterior dislocation without associated fracture is even more rare. A case of early recurrence of posterior atlantoaxial dislocation without fracture being in therapy of first closed reduction and then open reduction has not been previously reported. CASE SUMMARY: A 45-year-old female presented with traumatic posterior atlantoaxial dislocation (TPAD) of C1-C2 without associated fractures, and Frankel Grade B spinal cord function. She was successfully managed by immediate closed reduction under skull traction. Unexpectedly, 17 d later, re-dislocation was discovered. On day 28, closed reduction was performed as before but failed. Then, open reduction and posterior internal fixation with autologous iliac bone grafts was performed. By 6 mo after surgery, atlantoaxial joint fusion was achieved, and neurological function had recovered to Frankel Grade E. At 12 mo follow-up, she had lost only 15° of cervical rotation, and atlantoaxial complex instability in joint flexing and extending were no longer observed under fluoroscopy. CONCLUSION: Early assessment of transverse ligament is critical for TPAD without fracture avoiding re-dislocation after closed reduction. PMID:33644216 | PMC:PMC7896674 | DOI:10.12998/wjcc.v9.i6.1461 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Spontaneous small bowel perforation secondary to Vibrio parahaemolyticus infection: A case report

paythelady.612 shared this article with you from Inoreader Spontaneous small bowel perforation secondary to <em>Vibrio parahaemolyticus</em> infection: A case report Μέσω pubmed: "world j clin cases"... World J Clin Cases. 2021 Feb 16;9(5):1210-1214. doi: 10.12998/wjcc.v9.i5.1210. ABSTRACT BACKGROUND: Vibrio pararhaemolyticus (V. parahaemolyticus), a pathogen that commonly causes gastroenteritis, could potentially lead to a pandemic in Asia. Its pathogenesis and molecular mechanisms vary, and the severity of illness can be diverse, ranging from mild gastroenteritis, requiring only supportive care, to sepsis. CASE SUMMARY: We outline a case of a 71-year-old female who experienced an acute onset of severe abdominal tenderness after two days of vomiting and diarrhea prior to her emergency department visit. A small bowel perforation was diagnosed using computed tomography. The ascites cultured revealed infection due to V. parahaemolyticus. CONCLUSION: Our case is the first reported case of V. parahaemolyticus-induced gastroenteritis resulting in small bowel perforation. PMID:33644186 | PMC:PMC7896667 | DOI:10.12998/wjcc.v9.i5.1210 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Intrahepatic cholangiocarcinoma is more complex than we thought: A case report

paythelady.612 shared this article with you from Inoreader Intrahepatic cholangiocarcinoma is more complex than we thought: A case report Μέσω pubmed: "world j clin cases"... World J Clin Cases. 2021 Feb 26;9(6):1469-1474. doi: 10.12998/wjcc.v9.i6.1469. ABSTRACT BACKGROUND: Brain metastasis from intrahepatic cholangiocarcinoma is rare. To the best of our knowledge, only a few cases have been reported. The biological behavior was complex, and treatment requires further investigation. CASE SUMMARY: A 62-year-old woman complained of left limb weakness. Abdominal computed tomography showed a 5.0 cm × 5.6 cm lesion in the left lobe of the liver. Tumor markers were normal. Serological analysis indicated absence of hepatitis virus. Brain magnetic resonance imaging revealed a 1.0 cm × 1.3 cm mass in the right frontal lobe. Intrahepatic cholangiocarcinoma with brain metastasis was diagnosed by our liver cancer multidisciplinary team. After sufficient preparation, the patient underwent partial frontal lobotomy and left hemihepatectomy. Histopathological results confirmed that both the lesions were cholangioca rcinoma. Six cycles of gemcitabine combined with S1 were administered. During a 39 mo postoperative follow-up, no sign of local recurrence or distant metastasis was observed. CONCLUSION: This case expands our knowledge concerning the complex and heterogeneous nature of tumor metastasis. PMID:33644217 | PMC:PMC7896692 | DOI:10.12998/wjcc.v9.i6.1469 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Congenital hepatic fibrosis in a young boy with congenital hypothyroidism: A case report

paythelady.612 shared this article with you from Inoreader Congenital hepatic fibrosis in a young boy with congenital hypothyroidism: A case report Μέσω pubmed: "world j clin cases"... World J Clin Cases. 2021 Feb 26;9(6):1475-1482. doi: 10.12998/wjcc.v9.i6.1475. ABSTRACT BACKGROUND: Congenital hepatic fibrosis (CHF) is a rare autosomal recessive disorder characterized by variable degrees of periportal fibrosis and malformation of bile ducts. CHF is generally accompanied by a variety of conditions or syndromes with other organ involvement. CASE SUMMARY: We report a 5-year-4-month-old Chinese boy with congenital hypothyroidism (CH) diagnosed with CHF. The patient was diagnosed with CH by a newborn screening test and has since been taking levothyroxine. He has developed normally without neurocognitive deficits. Abnormal liver function was observed in the patient at the age of 4 years and 11 mo, and elevated levels of liver function indices were persistent for 5 mo. Radiological imaging indicated hepatospleno-megaly without narrowing of the portal vein but dilated splenic vein. A liver biopsy confirmed the patholo gical features of CHF. Genetic testing revealed two novel homozygous mutations, namely, c.2141-3T>C variant in PKHD1 related to CHF and c.2921G>A (p.R974H) in DUOX2 related to CH. The patient was treated with compound glycyrrhizin tablet, ursodeoxycholic acid, and levothyroxine after diagnosis. The patient achieved a favorable clinical outcome during a follow-up period of over 2 years. CONCLUSION: Herein, we report the first case of a Chinese boy with comorbidity of CHF and CH, carrying both PKHD1 gene and DUOX2 gene novel mutations. Liver biopsy and genetic testing should be considered for the diagnosis of coexistent liver disease in CH patients with unexplained abnormal liver function. PMID:33644218 | PMC:PMC7896672 | DOI:10.12998/wjcc.v9.i6.1475 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Venetoclax in combination with chidamide and dexamethasone in relapsed/refractory primary plasma cell leukemia without t(11;14): A case report

paythelady.612 shared this article with you from Inoreader Venetoclax in combination with chidamide and dexamethasone in relapsed/refractory primary plasma cell leukemia without t(11;14): A case report Μέσω pubmed: "world j clin cases"... World J Clin Cases. 2021 Feb 16;9(5):1175-1183. doi: 10.12998/wjcc.v9.i5.1175. ABSTRACT BACKGROUND: Conventional therapies for primary plasma cell leukemia (pPCL) are usually ineffective, with a short remission time with the use of multiple myeloma medications, showing aggressiveness of pPCL. B-cell lymphoma-2 inhibitor venetoclax is usually used for relapsed/refractory multiple myeloma (RRMM) with t(11;14). There are very few studies published on the use of venetoclax in pPCL without t(11;14). Similarly, histone deacetylase inhibitors are considered effective for the treatment of RRMM, but there are no reports on their use in pPCL. CASE SUMMARY: A 57-year-old woman with severe anemia, thrombocytopenia, multiple bone destruction, impaired renal function, and 42.7% of peripheral plasma cells is reported. After multiple chemotherapy regimens and chimeric antigen receptor T-cell treatment, the disease progressed again. The patient h ad very good partial response and was maintained for a long time on venetoclax in combination with chidamide and dexamethasone therapy. CONCLUSION: The success of venetoclax-chidamide-dexamethasone combination therapy in achieving a very good partial response suggested that it can be used for refractory/relapsed pPCL patients who have been exhausted with the use of various drug combinations and had poor survival outcomes. PMID:33644182 | PMC: PMC7896656 | DOI:10.12998/wjcc.v9.i5.1175 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Polidocanol sclerotherapy for multiple gastrointestinal hemangiomas: A case report

paythelady.612 shared this article with you from Inoreader Polidocanol sclerotherapy for multiple gastrointestinal hemangiomas: A case report Μέσω pubmed: "world j clin cases"... World J Clin Cases. 2021 Feb 26;9(6):1483-1489. doi: 10.12998/wjcc.v9.i6.1483. ABSTRACT BACKGROUND: Gastrointestinal (GI) hemangioma has a low incidence among systemic hemangiomas, and some GI hemangiomas occur in the intestine, stomach, and esophagus. Polidocanol has been increasingly used in sclerotherapy. However, this paper reports that minimally invasive treatment of multiple hemangiomas with large diameters can achieve satisfactory results by multipoint injection. CASE SUMMARY: A 46-year-old female patient was hospitalized in another hospital for cough. We accidentally found thickening of the lower esophagus by chest computed tomography. The patient was eventually diagnosed with multiple GI hemangiomas and underwent a series of examinations including esophagogastroduodenoscopy (EGD), endoscopic ultrasound, and magnetic resonance imaging. We calculated the dose of polidocanol according to the volumes of the hemangiomas, fixe d the target vein with the help of a transparent cap, and then administered polidocanol via multipoint injection into the hemangiomas under endoscopic guidance. EGD and endoscopic ultrasound showed that the hemangiomas disappeared. The color of the esophageal mucosa returned to normal 1 mo after sclerotherapy. CONCLUSION: Sclerotherapy may be a safe and effective method for treating multiple hemangiomas of the alimentary canal. PMID:33644219 | PMC:PMC7896683 | DOI:10.12998/wjcc.v9.i6.1483 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Imaging characteristics of a rare case of monostotic fibrous dysplasia of the sacrum: A case report

paythelady.612 shared this article with you from Inoreader Imaging characteristics of a rare case of monostotic fibrous dysplasia of the sacrum: A case report Μέσω pubmed: "world j clin cases"... World J Clin Cases. 2021 Feb 16;9(5):1111-1118. doi: 10.12998/wjcc.v9.i5.1111. ABSTRACT BACKGROUND: Fibrous dysplasia (FD) is a common benign intramedullary fibro-osseous lesion. Involvement of the spine is rare, with the literature including only case reports, and cases of monostotic FD (MFD) in the sacrum are extremely rare. A correct preoperative diagnosis of spinal MFD is important for clinicians to select proper treatment. CASE SUMMARY: We retrospectively assessed a case report of MFD in the sacrum. This patient was examined by computed tomography (CT) and magnetic resonance imaging (MRI), and the diagnosis was confirmed by pathology. A review of the literature was performed to analyze the imaging characteristics and differential diagnoses of spinal MFD. For our patient, the CT scan showed the lesion to be expansile, with ground glass opacity and a sclerotic rim. On MRI, the lesion showed iso-low signal intensity on T1WI and iso-high signal intensity on T2WI. A low signal rim was found on T1WI and T2WI. Our patient was treated by posterior focal excision, decompression, bone grafting, fusion and pedicle screw fixation. A satisfactory result was achieved, with pain disappearance. No complications had occurred at the 1-year follow up. CONCLUSION: MFD is an expansile osteolytic change. Ground glass opacity and a sclerotic margin are obvious characteristics. The lesion often involves the vertebral body and posterior element. Knowledge of these imaging characteristics of spinal FD could be helpful for diagnosis and prevent unnecessary procedures. PMID:33644174 | PMC:PMC7896654 | DOI:10.12998/wjcc.v9.i5.1111 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.