Nutrients, Vol. 11, Pages 2421: Anti-VEGF Signalling Mechanism in HUVECs by Melatonin, Serotonin,...
Nutrients, Vol. 11, Pages 2421: Anti-VEGF Signalling Mechanism in HUVECs by Melatonin, Serotonin, Hydroxytyrosol and Other Bioactive CompoundsNutrients, Vol. 11, Pages 2421: Anti-VEGF Signalling Mechanism in HUVECs by Melatonin, Serotonin, Hydroxytyrosol and Other Bioactive Compounds Nutrients doi: 10.3390/nu11102421 Authors: Ana B. Cerezo María Labrador Andrés Gutiérrez Ruth Hornedo-Ortega Ana M. Troncoso M. Carmen Garcia-Parrilla Angiogenesis drives evolution and destabilisation of atherosclerotic...
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International Journal of Environmental Research and Public HealthIJERPH, Vol. 16, Pages 3863: The Association Between Decompensated Liver Cirrhosis and Deep Neck Infection: Real-World EvidenceIJERPH, Vol. 16, Pages 3863: The Association Between Decompensated Liver Cirrhosis and Deep Neck Infection: Real-World Evidence International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16203863 Authors: Ming-Shao Tsai Geng-He Chang Wei-Ming Chen Chia-Yen Liu Meng-Hung Lin Pey-Jium...
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International Journal of Molecular SciencesIJMS, Vol. 20, Pages 5035: Andrographolide Ameliorates Rheumatoid Arthritis by Regulating the Apoptosis–NETosis Balance of NeutrophilsIJMS, Vol. 20, Pages 5035: Andrographolide Ameliorates Rheumatoid Arthritis by Regulating the Apoptosis–NETosis Balance of Neutrophils International Journal of Molecular Sciences doi: 10.3390/ijms20205035 Authors: Xiaohong Li Kai Yuan Qingqing Zhu Qingyi Lu Haixu Jiang Mengmeng Zhu Guangrui Huang Anlong Xu Rheumatoid arthritis...
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International Journal of Environmental Research and Public HealthIJERPH, Vol. 16, Pages 3835: Water Source Preferences and Water Quality Perceptions among Women in the Eastern Region, Ghana: A Grounded Theory StudyIJERPH, Vol. 16, Pages 3835: Water Source Preferences and Water Quality Perceptions among Women in the Eastern Region, Ghana: A Grounded Theory Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16203835 Authors: Jhanel F. Chew Laura Corlin Fernando...
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Cells, Vol. 8, Pages 1234: IL-2 Therapy Diminishes Renal Inflammation and the Activity of Kidney-Infiltrating CD4+ T Cells in Murine Lupus NephritisCells, Vol. 8, Pages 1234: IL-2 Therapy Diminishes Renal Inflammation and the Activity of Kidney-Infiltrating CD4+ T Cells in Murine Lupus Nephritis Cells doi: 10.3390/cells8101234 Authors: Angelika Rose Caroline von Spee-Mayer Lutz Kloke Kaiyin Wu Anja Kühl Philipp Enghard Gerd-Rüdiger Burmester Gabriela Riemekasten Jens Y. Humrich An acquired deficiency...
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Antibiotics, Vol. 8, Pages 183: The Long-Term Persistence of Borrelia burgdorferi Antigens and DNA in the Tissues of a Patient with Lyme DiseaseAntibiotics, Vol. 8, Pages 183: The Long-Term Persistence of Borrelia burgdorferi Antigens and DNA in the Tissues of a Patient with Lyme Disease Antibiotics doi: 10.3390/antibiotics8040183 Authors: Eva Sapi Rumanah S. Kasliwala Hebo Ismail Jason P. Torres Michael Oldakowski Sarah Markland Gauri Gaur Anthony Melillo Klaus Eisendle Kenneth B. Liegner Jenny...
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BMC Evolutionary BiologyImpact of low sperm competition on male reproductive trait allometries in a bush-cricketStudying reproductive trait allometries can help to understand optimal male investment strategies under sexual selection. In promiscuous mating systems, studies across several taxa suggest that testes allometr...Most Recent Articles: BMC Evolutionary BiologyFri Oct 11, 2019 03:00Chromosomal phylogeny and comparative chromosome painting among Neacomys species (Rodentia, Sigmodontinae) from...
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Risk of Post-Operative, Pre-Radiotherapy Contralateral Neck Recurrence in Patients Treated with Surgery Followed by Adjuvant Radiotherapy for Human Papilloma Virus-Associated Tonsil Cancer.Related ArticlesRisk of Post-Operative, Pre-Radiotherapy Contralateral Neck Recurrence in Patients Treated with Surgery Followed by Adjuvant Radiotherapy for Human Papilloma Virus-Associated Tonsil Cancer. Br J Radiol. 2019 Oct 10;:20190466 Authors: Gershowitz J, Chao HH, Doucette A, Lukens JN, Swisher-McClure...
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Two novel TSC2 mutations in renal epithelioid angiomyolipoma sensitive to everolimus.Related ArticlesTwo novel TSC2 mutations in renal epithelioid angiomyolipoma sensitive to everolimus. Cancer Biol Ther. 2019 Oct 10;:1-8 Authors: Wang T, Xie S, Luo R, Shi L, Bai P, Wang X, Wan R, Deng J, Wu Z, Li W, Xiao W, Wang Y, Chen B, Zhang K, Xing J Abstract People who suffers renal angiomyolipoma (AML) has a low quality of life. It is widely known that genetic factors including TSC2 mutation contribute to...
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Optogenetic auditory fMRI reveals the effects of visual cortical inputs on auditory midbrain response.Related ArticlesOptogenetic auditory fMRI reveals the effects of visual cortical inputs on auditory midbrain response. Sci Rep. 2018 06 07;8(1):8736 Authors: Leong ATL, Dong CM, Gao PP, Chan RW, To A, Sanes DH, Wu EX Abstract Sensory cortices contain extensive descending (corticofugal) pathways, yet their impact on brainstem processing - particularly across sensory systems - remains poorly understood....
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A Surgical Variant of the Pre-Lacrimal Approach to the Maxillary Sinus.Related ArticlesA Surgical Variant of the Pre-Lacrimal Approach to the Maxillary Sinus. Iran J Otorhinolaryngol. 2019 Sep;31(106):327-328 Authors: Preti A, Turri-Zanoni M, Arosio AD, Castelnuovo P, Battaglia P Abstract Introduction: When dealing with maxillary sinus pathology, some areas of the sinus remain difficult to examine. In this regard, the pre-lacrimal approach is a minimally invasive technique to reach anterolateral...
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Contribution of retrotransposition to developmental disordersNature Communications, Published online: 11 October 2019; doi:10.1038/s41467-019-12520-yRetrotransposition events have been linked to some human disorders. Here, Gardner et al. systematically search for mobile genetic elements (ME) in trio whole exome-sequencing datasets and ascertain 9 de novo MEs and further estimate genome-wide germline ME burden and constraint.Nature Communications - current - nature.com science feedsFri Oct 11, 2019...
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Discordant Marker Expression Between Invasive Breast Carcinoma and Corresponding Synchronous and Preceding DCISDuctal carcinoma in situ (DCIS) is considered a potential precursor of invasive breast carcinoma (IBC). Studies aiming to find markers involved in DCIS progression generally have compared characteristics of IBC lesions with those of adjacent synchronous DCIS lesions. The question remains whether synchronous DCIS and IBC comparisons are a good surrogate for primary DCIS and subsequent IBC....
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Combined gadoxetic acid and gadobenate dimeglumine enhanced liver MRI: a parameter optimization studyAbstract Purpose To demonstrate the feasibility of combined delayed-phase gadoxetic acid (GA) and gadobenate dimeglumine (GD) enhanced liver MRI for improved detection of liver metastases, and to optimize contrast agent dose, timing, and flip angle (FA). Methods Fourteen healthy volunteers underwent liver MRI at 3.0T at two visits during which they received...Latest Results for Abdominal Radiology03:00The...
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[ASAP] Molecular Structure of the Long Periodicity Phase in the Stratum CorneumJournal of the American Chemical SocietyDOI: 10.1021/jacs.9b08995Journal of the American Chemical Society: Latest Articles (ACS Publications)Fri Oct 11, 2019 07:00[ASAP] Hybrid Photo-induced Copolymerization of Ring-Strained and Vinyl Monomers Utilizing Metal-Free Ring-Opening Metathesis Polymerization ConditionsJournal of the American Chemical SocietyDOI: 10.1021/jacs.9b09025Journal of the American Chemical Society: Latest...
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Radiotherapy in India: History, current scenario and proposed solutionsAnusheel Munshi, Tharmarnadar Ganesh, Bidhu K MohantiIndian Journal of Cancer 2019 56(4):359-363 The history and current status of a biomedical discipline in a country or region provide important health system indicators. During the last one hundred years, radiotherapy has established its position as a vital specialty in cancer management. It has proved to be one of the most cost effective ways of treating cancer providing both...
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Impact of low sperm competition on male reproductive trait allometries in a bush-cricket Studying...
Impact of low sperm competition on male reproductive trait allometries in a bush-cricketStudying reproductive trait allometries can help to understand optimal male investment strategies under sexual selection. In promiscuous mating systems, studies across several taxa suggest that testes allometr...BMC Evolutionary Biology - Latest ArticlesFri Oct 11, 2019 03:00Chromosomal phylogeny and comparative chromosome painting among Neacomys species (Rodentia, Sigmodontinae) from eastern AmazoniaThe Neacomys...
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Duplication and divergence of the retrovirus restriction gene Fv1 in Mus caroli mice allows protection from multiple retroviruses [NEW RESULTS]Viruses and their hosts are locked in an evolutionary race where resistance to infection is acquired by the hosts while viruses develop strategies to circumvent these host defenses. Forming one arm of the host defense armory are cell autonomous restriction factors like Fv1. Originally described as protecting laboratory mice from infection by murine leukemia...
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Engineering Surface Patterning of Colloidal Rings through Plateau–Rayleigh InstabilityPlateau–Rayleigh (P‐R) instability occurring on Brownian colloidal particles was observed and used for the surface patterning of colloidal rings. Multi‐patch rings, one‐patch rings, and patchy disks were synthesized in high yields. The number and size of patches are tunable, and the patches were functionalized to prepare pH‐responsive inverse patchy colloids. Abstract Plateau–Rayleigh (P‐R) instability occurring...
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Frequency Therapeutics Begins Phase 2a Testing on Drug to Cure Hearing LossFrequency Therapeutics has commenced dosing in a Phase 2a clinical study of FX-322, a drug designed to regenerate auditory hair cells and restore hearing function. This multi-center, randomized, double-blind, placebo-controlled study aims to further establish the positive hearing signal observed in a Phase 1/2 study, including improved clarity of sound and word recognition. Frequency also hopes to evaluate safety and define...
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Investigation of insulin-like growth factors/insulin-like growth factor binding proteins regulation in metabolic syndrome patientsThe insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are thought to play a significant role in metabolic pathways and glucose metabolism. Unregulated levels of IGFs/IGFBPs have been assoc...BMC Research NotesFri Oct 11, 2019 03:00Accuracy of the lower third molar radiographic imaging to estimate age among Ugandan young peopleDental development is...
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Gastrointestinal histoplasmosis mimicking peritonitis carcinomatosis: a rare case of an emergent surgical presentation of HIV de novoAbstractGastrointestinal perforation due to infection, including disseminated histoplasmosis, is a rare cause of the surgical acute abdomen, especially in an apparently healthy patient. We describe a rare case of gastrointestinal histoplasmosis-induced small intestine perforation as the first manifestation of acquired immune deficiency syndrome in a healthy patient....
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Mass balance and metabolite profiling of 14 C-guadecitabine in patients with advanced cancerSummary Purpose The objective of this mass balance trial was to determine the excretory pathways and metabolic profile of the novel anticancer agent guadecitabine in humans after administration of a 14C-radiolabeled dose of guadecitabine. Experimental design Included patients received at least one cycle of 45 mg/m2 guadecitabine subcutaneously as once-daily doses on Days 1 to 5 of a 28-day cycle, of which...
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Metamorphosis: Less Is More in Varicose Vein SurgeryPublication date: Available online 10 October 2019Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Sergi Bellmunt-Montoya, José M. EscribanoScienceDirect Publication: European Journal of Vascular and Endovascular SurgeryFri Oct 11, 2019 16:22Combination of Colour Duplex and Contrast Enhanced Ultrasound as an Alternative to Computed Tomography Angiography in Isolated Mesenteric Artery Dissection SurveillancePublication date:...
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The effect of dopamine on pulmonary diffusing capacity and capillary blood volume responses to exercise in young healthy humansAbstract Purpose: Pulmonary capillary blood volume (Vc) and diffusing membrane capacity (Dm) expansion are important contributors to the increased pulmonary diffusing capacity (DLCO) observed during upright exercise. Dopamine is a pulmonary vascular vasodilator, and recent studies suggest that dopamine may play a role in Vc regulation through changes in pulmonary vascular...
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CD36 expression on oral squamous cell carcinoma cells correlates with enhanced proliferation and migratory activityAbstract Objective Recent studies have demonstrated the pro‐tumour role of CD36 in multiple cancer types. However, its role has not been well elucidated in oral squamous cell carcinoma (OSCC). Here, we aimed to evaluate the role of CD36 in proliferation and migration of OSCC cells. Methods Human OSCC cell lines HSC‐2, HSC‐3, HSC‐4, and Ca9‐22 were assessed for proliferation by staining...
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Introducing the Ambu® aScope™ for speech valve retrieval: How I do itClinical OtolaryngologyFri Oct 11, 2019 11:34The efficacy of statins as otoprotective agents: A systematic reviewAbstract Objective This systematic review examined the current literature, summarized research findings and identified research gaps regarding the efficacy of statins on audiological outcomes. Methods Systematic search of electronic databases and grey literature was performed. Eligibility criteria was the study of a statin...
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Activity-Based Training Reverses Spinal Cord Injury–Induced Changes in Kidney Receptor Densities and Membrane ProteinsJournal of Neurotrauma, Ahead of Print.Journal of NeurotraumaFri Oct 11, 2019 10:00Neuron-Derived Plasma Exosome Proteins after Remote Traumatic Brain InjuryJournal of Neurotrauma, Ahead of Print.Journal of NeurotraumaFri Oct 11, 2019 10:00Dexamethasone Therapy in Symptomatic Chronic Subdural Hematoma (DECSA–R): A Retrospective Evaluation of Initial Corticosteroid Therapy versus Primary...
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Intradural disc herniation at the L1–L2 level: A case report and literature reviewIntradural disc herniation at the L1–L2 level: A case report and literature review Category: Article Type: Raysa Moreira Aprígio, Ricardo Lourenço Caramanti, Felipe Oliveira Rodrigues Santos, Isabela Pinho Tigre Maia, Fernando Manuel Rana Filipe, Dionei Freitas de Moraes, Eduardo Carlos da Silva, Fabiano Morais NogueiraDepartment of Neurosurgery, São José do Rio Preto Medical Faculty, São José...Surgical neurology internationalFri...
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A modification for the calculation of water depth profiles in oil‐treated skin by in vivo confocal Raman microscopyAbstract In this study, an extended calculation method for the determination of the water profiles in oil‐treated skin is proposed, which is based on the calculation of the ratio between the Raman band intensities of water (3350–3550 cm‐1) and keratin Amide I at 1650 cm‐1. The proposed method is compared with the conventional method based on the ratio of the Raman band intensities of...
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Analyzing Tumor Gene Expression Factors with the CorExplorer Web PortalWe introduce the CorExplorer web portal, an resource for exploration of tumor RNA sequencing factors found by the machine learning algorithm CorEx (Correlation Explanation), and show how factors can be analyzed relative to survival, database annotations, protein-protein interactions, and one another to gain insight into tumor biology and therapeutic interventions.JoVE: Journal of Visualized ExperimentsFri Oct 11, 2019 22:18Optimized...
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Central compartment atopic disease: prevalence of allergy and asthma compared with other subtypes...
Central compartment atopic disease: prevalence of allergy and asthma compared with other subtypes of chronic rhinosinusitis with nasal polyps.Related ArticlesCentral compartment atopic disease: prevalence of allergy and asthma compared with other subtypes of chronic rhinosinusitis with nasal polyps. Int Forum Allergy Rhinol. 2019 Oct 10;: Authors: Marcus S, Schertzer J, Roland LT, Wise SK, Levy JM, DelGaudio JM Abstract BACKGROUND: Central compartment atopic disease (CCAD) is a recently described...
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The de Novo Reference Genome and Transcriptome Assemblies of the Wild Tomato Species Solanum chilense Highlights Birth and Death of NLR Genes Between Tomato SpeciesWild tomato species, like Solanum chilense, are important germplasm resources for enhanced biotic and abiotic stress resistance in tomato breeding. S. chilense also serves as a model to study adaptation of plants to drought and the evolution of seed banks. The absence of a well-annotated reference genome in this compulsory outcrossing,...
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Postprandial leptin and adiponectin in response to sugar and fat in obese and normal weight individualsAbstract Purpose Adipokines produced by white adipose tissue are central in the development of lifestyle diseases. Individuals in industrialized countries spend a substantial part of life in the non-fasting, postprandial state, which is associated with increased oxidation and inflammation. The aim was to study postprandial adiponectin and leptin levels after an oral fat tolerance test (OFTT) and...
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The age-adjusted Charlson comorbidity index as a predictor of overall survival of surgically treated non-metastatic clear cell renal cell carcinomaAbstract Purpose No study has evaluated the prognostic impact of the age-adjusted Charlson comorbidity index (AACI) in those with renal cell carcinoma (RCC). This study aimed to evaluate the utility of the AACI for predicting long-term survival in patients with surgically treated non-metastatic clear cell RCC (ccRCC). Methods Data from 698 patients with...
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iRhythm-Verily Partnership: Interview with iRhythm CEO Kevin KingiRhythm and Verily announced a partnership last month to "co-develop solutions intended to provide early warning, diagnosis and management for patients, particularly for those with silent or undiagnosed AF." We spoke with iRhythm CEO Kevin King to understand how the two companies complement each other and how they can solve the problem together. Ben Ouyang, Medgadget: Tell us about yourself. Kevin King: I've been CEO of iRhythm now...
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[ASAP] Centrifugal-Driven Droplet Generation Method with Minimal Waste for Single-Cell Whole Genome AmplificationAnalytical ChemistryDOI: 10.1021/acs.analchem.9b02786Analytical ChemistryFri Oct 11, 2019 07:00[ASAP] Variable-Angle Nanoplasmonic Fluorescence Microscopy: An Axially Resolved Method for Tracking the Endocytic PathwayAnalytical ChemistryDOI: 10.1021/acs.analchem.9b02845Analytical ChemistryFri Oct 11, 2019 07:00[ASAP] Ratiometric Imaging of ?-Glutamyl Transpeptidase Unperturbed by pH, Polarity,...
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Tumor-Infiltrating CD1a + DCs and CD8 + /FoxP3 + Ratios Served as Predictors for Clinical Outcomes in Tongue Squamous Cell Carcinoma PatientsAbstract Tumor-infiltrating immune cells engage in an extensive crosstalk with tumors and act as two-edged swords by inhibiting or promoting cancer growth. Therefore, identifying the density and prognostic values of tumor-infiltrating immune cells will provide valuable tips for cancer treatments. In this study, we identified the density of tumor inflammatory...
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Associations among neighborhood greenspace, neighborhood violence, and children's asthma control in an urban cityAmong 6.1 million children with asthma,1 38% have uncontrolled asthma leading to increased pediatric emergency department (ED) visits, hospitalizations, and healthcare costs.2 Uncontrolled asthma unequally harms children from lower-income, racial and ethnic minority families.1 Disparities in asthma control have been attributed to differential exposures to poverty, living in unsafe, stressful...
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A case series of seven patients with recurrent median nerve neuropathy treated by the revision surgery of median nerve neurolysis and wrapping with radial artery perforator adipose flapAdhesion neuropathy of the median nerve with persistent pain can be a challenging problem. Currently, coverage of the median nerve with a well-vascularized soft tissue is deemed necessary after secondary neurolysis. Herein, we reviewed the outcomes of seven patients with a persistent median nerve neuropathy after a...
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Φυσικό αντικαταθλιπτικό «πιάνει» σε τρεις εβδομάδες χωρίς παρενέργειεςΗ υγιεινή διατροφή δεν χαρίζει μόνο υγεία και ισορροπημένο βάρος, αλλά και… ευτυχία υποστηρίζουν αυστραλοί ερευνητές. Η αντικαταθλιπτική δράση της υγιεινής και ισορροπημένης διατροφής παρατηρήθηκε σε μικρή έρευνα σε νεαρούς ενήλικες με φτωχή διατροφή και μέτρια προς έντονα συμπτώματα κατάθλιψης. Όσοι υιοθέτησαν πιο υγιεινές διατροφικές επιλογές ανέφεραν λιγότερα συμπτώματα άγχους και ανησυχίας και πολύ καλύτερη διάθεση μέσα σε...
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Trends in Imaging Workup of the Male Breast: Experience from a Single Center.Related ArticlesTrends in Imaging Workup of the Male Breast: Experience from a Single Center. Isr Med Assoc J. 2019 Oct;21(10):666-670 Authors: Lawson P, Nissan N, Faermann R, Halshtok O, Shalmon A, Gotleib M, Akiva Ben David M, Sklair Levy M Abstract BACKGROUND: Male breast cancer (MBC) is a rare disease representing less than 1% of breast cancers. In the absence of a screening program, such as for females, the diagnostic...
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The roles of fission yeast exonuclease 5 in nuclear and mitochondrial genome stabilityPublication date: November 2019Source: DNA Repair, Volume 83Author(s): Justin L. Sparks, Kimberly J. Gerik, Carrie M. Stith, Bonita L. Yoder, Peter M. BurgersAbstractThe Exo5 family consists of bi-directional, single-stranded DNA-specific exonucleases that contain an iron-sulfur cluster as a structural motif and have multiple roles in DNA metabolism. S. cerevisiae Exo5 is essential for mitochondrial genome maintenance,...
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Radiocontrast media: Applications and concernsRajiv Mahajan, Pushpinder SinghInternational Journal of Applied and Basic Medical Research 2019 9(4):191-192Emergency focused assessment with sonography in blunt trauma abdomenShradha Engles, Navdeep Singh Saini, Shubra RathoreInternational Journal of Applied and Basic Medical Research 2019 9(4):193-196Background: Focused assessment with sonography in trauma (FAST) being a rapid noninvasive examination is used primarily to evaluate for the evidence of...
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Will health marketplace apps improve laboratories?Jacob McKnight, Ken FlemingIndian Journal of Cancer 2019 56(4):291-292Revisiting adjuvant ovarian suppression in premenopausal breast cancer patientsWaseem Abbas, Ranga Raju RaoIndian Journal of Cancer 2019 56(4):293-296Adjuvant ovarian suppression, on addition to chemotherapy, reduces the risk of breast cancer in pre-menopausal women after surgery and adjuvant hormonal therapy. Suppression of Ovarian Function Trial (SOFT) and Tamoxifen and Exemestane...
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Institute-based sustainable palliative care program: A unique initiative of "cancer treatment center program"Sushma BhatnagarIndian Journal of Palliative Care 2019 25(4):485-486The psychosocial and spiritual experiences of patients with advanced incurable illness in Bangladesh: A cross-sectional observational studyMegan E Doherty, Liam Power, Rubayet Rahman, Lailatul Ferdous, Kazi M Akter, Sayeda Sharmin Quadir, Sadia Sharmin, Emily Evans, Farzana KhanIndian Journal of Palliative Care 2019 25(4):487-493Context:...
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DOCA/Salt: much more than a model of hypertension.Mineralocorticoid excess produces inflammation, hypertrophy, and fibrosis independently of its effects on sodium balance and blood pressure. Mineralocorticoids act through the mineralocorticoid receptor (MR) which mediates transcriptional and rapid non-genomic effects in non-epithelial cells including cardiomyocytes, vascular endothelial and smooth muscle cells, macrophages and T-cells, and neurons. DOCA, an inactive pro-drug, is converted to DOC...
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Periocular esthetic procedures: Do patients understand the risks?Abdullah S Al-MujainiOman Journal of Ophthalmology 2019 12(3):143-144Prevalence of visual impairment in school-going children among the rural and urban setups in the Udupi district of Karnataka, India: A cross-sectional studyAvinash V Prabhu, Ramesh S Ve, Juthika Talukdar, Varalakshmi ChandrasekaranOman Journal of Ophthalmology 2019 12(3):145-149AIM: The aim of this study is to estimate the prevalence of visual impairment among school-going...
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Treatment Failures of Direct Oral AnticoagulantsBackground: Use of direct oral anticoagulants (DOACs) has increased over the years, because they have become a safe and effective alternative to the Vitamin-K antagonists in various clinical scenarios. With their increased use, reports have emerged describing their failure. Study Question: What are the patient characteristics and clinical settings in which DOAC treatment failure manifests? Data Sources: We searched published reports in Google Scholar,...
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Risk factors, pattern of presentation, methods of diagnosis, and results of treatment of acute portal vein thrombosis: A multicenter studyMohamed Salem Al Saeed, Bilal O Al-Jiffry, Alaa Younes, Samir Badr, Tamer Abdel-Rahman, Mohamed Hatem, Mahmoud El-MeteiniSaudi Journal for Health Sciences 0 0(0):0-0Background and Aim of the Work: Portal vein thrombosis (PVT) is a serious condition; however, the outcome may be improved by early recognition and prompt management. The aim of this multicenter retrospective...
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Oral isotretinoin for treating mucocutaneous human papillomavirus infections: A systematic review and meta-analysisTing-Hua Yang, Tsai-Hsien Lee, Yu-Chen HuangIndian Journal of Dermatology, Venereology, and Leprology 2019 85(6):569-577Introduction: Some viral warts are refractory to treatment, some others tend to recur. Oral isotretinoin is useful against warts to varying degrees. Objective: To determine the efficacy of oral isotretinoin for treating mucocutaneous human papillomavirus infections....
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Dental practice management in the dental curriculumThangadurai MaheswaranIndian Journal of Multidisciplinary Dentistry 2019 9(1):1-2Patient satisfaction after rehabilitation with tooth-supported fixed partial dentures: A cross-sectional studyRajlakshmi Banerjee, Vijeta Gajbhiye, Usha Radke, Trupti BangareIndian Journal of Multidisciplinary Dentistry 2019 9(1):3-8Introduction: Patients' perceptions of their oral health status are important outcomes in prosthodontics. There is an increasing realization...
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Steintherapie bei Kindern: Medikamentöse und chirurgische AnsätzeRadium-223 zur Therapie des metastasierten kastrationsresistenten Prostatakarzinoms (mCRPC)ZusammenfassungHintergrundRadium-223 verlängert das Gesamtüberleben und erhält die Lebensqualität von Patienten mit metastasiertem kastrationsresistentem Prostatakarzinom (mCRPC) und symptomatischen Knochenmetastasen ohne bekannte Viszeralmetastasen. Kombiniert mit einem LHRH-Analogon kann Radium-223 in der therapeutischen Sequenz eingesetzt werden,...
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Mentor's Self-Efficacy Trajectories During a Mentoring Program for At-Risk AdolescentsAbstractThe concept of self-efficacy is dynamic and may change over time. Mentors of youth exposed to risk factors are likely to experience shifts in the degree to which they feel confident in their ability to form a positive mentoring bond with their mentee, potentially affecting the quality of the relationship. Based on previous literature, mentors' personality traits, their perceptions of positive mentee behaviors,...
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Die aktualisierte S3-Leitlinie SchizophrenieZusammenfassungDie Schizophrenie ist eine der schwersten psychischen Erkrankungen und führt zu erheblichen persönlichen und sozialen Beeinträchtigungen der betroffenen Personen. Die Erkrankung verläuft häufig rezidivierend, resultiert in einer erhöhten Mortalität, bedingt mit die höchsten sozioökonomischen Kosten aller Erkrankungen und die betroffenen Personen erleben in vielen Alltags- und Behandlungssituationen eine Stigmatisierung. Die Revision der 1998...
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A time travel story: metagenomic analyses decipher the unknown geographical shift and the storage history of possibly smuggled antique marble statuesAbstractIn this study, three possibly smuggled marble statues of an unknown origin, two human torsi (a female and a male) and a small head, were subjected to molecular analyses. The aim was to reconstruct the history of the storage of each single statue, to infer the possible relationship among them, and to elucidate their geographical shift. A genetic...
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HEAD NECK 1.Normative Responses to Clinical Tests for Cervicogenic Dizziness: Clinical Cervical Torsion Test and Head-Neck Differentiation Test.Science.gov (United States)Treleaven, Julia; Joloud, Vladimir; Nevo, Yoav; Radcliffe, Clare; Ryder, Mollie2019-10-04 PubMedDOI: 10.1093/ptj/pzz143 ISSN: 0031-9023Keywords: Asymptomatic, Cervical Torsion Test, Cervicogenic Dizziness, Head-Neck Differentiation TestThe clinical diagnosis of cervicogenic dizziness (CGD) is challenging because of a lack of sensitive...
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This World Arthritis Day, Springer Nature brings you articles, collections, and books on rheumatology, from the latest research on psoriatic arthritis to arthralgia and fatigue management. Below, you can read samples from our books, submit your papers to our latest BMC collection, and share our free-to-read and open access articles with your colleagues. Articles These select articles on rheumatology, covering topics from prevention and management to rheumatic and musculoskeletal diseases,...
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Effects of Tropilaelaps mercedesae on midgut bacterial diversity of Apis melliferaAbstractTropilaelaps mercedesae is an ectoparasite of Apis mellifera in Asia and is considered a major threat to honey bee health. Herein, we used the Illumina MiSeq platform 16S rDNA Amplicon Sequencing targeting the V3–V4 regions and analysed the effects on the midgut bacterial communities of honey bees infested with T. mercedesae. The overall bacterial community in honey bees infested with T. mercedesae were observed...
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RESEARCH,Pathology of Senegalese breast cancersMegan Burke Fitzpatrick et al.Breast cancer is the most common cancer affecting women in Africa (100per 100,000), and is the second leading cause of cancer deaths (49 per 100,000). Western African countries have an average estimated breast cancer incidence of 20-25 per 100,000 women, second only to cervical cancer. Age-standardized incidence rates are comparatively lower in Senegal (22.4 per 100,000) than other regional rates (i.e Nigeria 50.4 per...
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Mitochondrial oncobioenergetics of prostate tumorigenesis (Review)Praveen Kumar VayalilView Abstract ❯Sonic Hedgehog signaling pathway as a potential target to inhibit the progression of hepatocellular carcinoma (Review)Kuo‑Shyang Jeng, Chi‑Juei Jeng, Wen‑Juei Jeng, I‑Shyan Sheen, Shih‑Yun Li, Chuen‑Miin Leu, Yeou‑Guang Tsay, Chiung‑Fang ChangView Abstract ❯Role of circular RNA in hematological malignancies (Review)Mei Mei, Yingjun Wang, Zhaoming Li, Mingzhi ZhangView Abstract ❯Molecular mechanisms...
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Clinician Perception of a Machine Learning–Based Early Warning System Designed to Predict Severe Sepsis and Septic Shock*Objective: To assess clinician perceptions of a machine learning–based early warning system to predict severe sepsis and septic shock (Early Warning System 2.0). Design: Prospective observational study. Setting: Tertiary teaching hospital in Philadelphia, PA. Patients: Non-ICU admissions November–December 2016. Interventions: During a 6-week study period conducted 5 months after...
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Association of rosacea with inflammatory bowel disease: A MOOSE-compliant meta-analysisRosacea has been reported with several systemic comorbidities, but its relationship with inflammatory bowel disease (IBD) is unclear. Thus, our objective is to conduct a meta-analysis on the association of rosacea with IBD. We conduct a meta-analysis and searched MEDLINE, CENTRAL, and Embase databases for case-controlled and cohort studies that assessed the association of rosacea with IBD from inception to July...
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Association of rosacea with inflammatory bowel disease: A MOOSE-compliant meta-analysisRosacea has been reported with several systemic comorbidities, but its relationship with inflammatory bowel disease (IBD) is unclear. Thus, our objective is to conduct a meta-analysis on the association of rosacea with IBD. We conduct a meta-analysis and searched MEDLINE, CENTRAL, and Embase databases for case-controlled and cohort studies that assessed the association of rosacea with IBD from inception to July...
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Fatty acid-binding proteins: functional understanding and diagnostic implicationsPurpose of review Fatty acid-binding proteins (FABPs) are a family of small, abundant proteins with highly tissue-specific expression patterns whose different functions remain incompletely understood. The purpose of this review is to summarize recent findings regarding FABP functions and mechanisms of action, including their potential utilization as serum markers of tissue-specific metabolic diseases. Recent findings...
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Advances in gastrointestinal immunologyNo abstract availableNutritional regulators of intestinal inflammationPurpose of review Recent knowledge teaches us that food is one of the most important environmental factors affecting our health from disease prevention to cause. Food is one of the key players in the normal gut microenvironment, affecting microbial composition, function, gut barrier and host immunity. This review aims to summarize the current data on food components as regulators of intestinal...
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Influenza (Flu)2019 - 2020 Flu SeasonOctober 11, 2019www.cdc.gov/fluWeekly U.S. Influenza Surveillance ReportFluView has been updated! The first report of the 2019-2020 is now available. CDC's Influenza Division produces a weekly influenza surveillance report. According to this week's report (Sept 29 - Oct 5), low level influenza activity is occurring in the United States at this time. Learn MoreMMWR: Summer Flu Activity in the U.S. and Composition of the 2020 Southern Hemisphere Flu VaccineSummer...
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Update: Interim Guidance for Health Care Providers Evaluating and Caring for Patients with Suspected E-cigarette, or Vaping, Product Use Associated Lung Injury — United States, October 2019David A. Siegel, MD; Tara C. Jatlaoui, MD; Emily H. Koumans, MD; et al.Based on the most current data, CDC's updated interim guidance provides a framework for health care providers in their initial assessment, evaluation, management, and follow-up of persons with symptoms of e-cigarette, or vaping, product use...
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Helping Babies Sleep Safely , Expecting or caring for a baby? Take these steps to help baby sleep safely and reduce the risk of sleep-related infant deaths, including sudden infant death syndrome (SIDS).Learn MoreNational Latinx AIDS Awareness DayNational Latinx AIDS Awareness Day (NLAAD), coordinated by the Latino Commission on AIDS, is October 15. This year's theme, Living with HIV or not … we're fighting this together, reminds us that regardless of our HIV status, we can work together to reduce...
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Ζαγόρι: Τα 5 πιο αυθεντικά χωριά του Πατήστε εδώ8 ξενώνες για το φθινόπωροΚαππαδοκία: Η τέχνη της φύσηςΠατήστε εδώΠατήστε εδώΛουγκάνο: Μια Ελβετίδα με ιταλικό ταμπεραμέντοΠατήστε εδώ
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How Culture is Understood in Faculty Development in the Health Professions: A Scoping ReviewPurpose: To examine the ways in which culture is conceptualized in faculty development (FD) in the health professions. Method: The authors searched PubMed, Web of Science, ERIC, and CINAHL, as well as the reference lists of identified publications, for articles on culture and FD published between 2006 and 2018. Based on inclusion criteria developed iteratively, they screened all articles. A total of 955 articles...
Fri Oct 11, 2019 09:57
The New England Journal of Medicine: Search Results in Emergency MedicineAlgorithm-Aided Prediction of Patient Preferences — An Ethics Sneak PeekThe use of artificial intelligence (AI) is increasingly common in medicine, as it is in other fields. Just as AI systems using natural language processing answer legal questions, predict court decisions, and prepare contracts, and as self-driving cars gather traffic information so they can make and…The New England Journal of Medicine: Search Results in Emergency...
Fri Oct 11, 2019 09:44
Treatment package time in node-positive cutaneous head and neck squamous cell carcinomaPublication date: Available online 10 October 2019Source: Practical Radiation OncologyAuthor(s): Christopher P. Daniels, Mathias Bressel, June Corry, Aidan Cole, Margaret S-T Chua, Albert Tiong, Nir Hirshoren, Ben Dixon, Lachlan J. McDowellAbstractPurposeTreatment package time (TPT) prolongation is associated with lower overall survival (OS) and locoregional control in mucosal head and neck SCC (mHNSCC) but there...
Fri Oct 11, 2019 09:43
Musical training sharpens behavioral tuning more saliently than peripheral tuningMusical training appears to enhance performance at both peripheral and central auditory sites. We compared behavioral and peripheral frequency tuning in normal-hearing musicians and nonmusicians, whose native language is Mandarin. The results indicate that, at higher probe frequencies, musical training sharpens behavioral tuning more saliently than peripheral tuning. The improved peripheral tuning for musician appears...
Fri Oct 11, 2019 09:42
Tumour‐suppressive circRNAs: Mechanisms underlying their suppression of tumour occurrence and use...
Tumour‐suppressive circRNAs: Mechanisms underlying their suppression of tumour occurrence and use as therapeutic targetsAbstract Circular RNAs (circRNAs) exhibit a covalently closed circular conformation and are structurally stable. Those circRNAs with tumour‐suppressive properties play an important role in tumorigenesis and metastasis and thus may be used as therapeutic targets of cancers. Here, we review the current understandings of the classification of circRNAs and summarise the functions and...
Fri Oct 11, 2019 09:40
Voice , Self-Assessment of Vocal Fatigue in Muscle Tension Dysphonia and Vocal Nodules: A Preliminary Analysis of the Discriminatory Potential of the Croatian Adaptation of the Vocal Fatigue Index (VFI-C)Publication date: Available online 9 October 2019Source: Journal of VoiceAuthor(s): Ana Bonetti, Luka Bonetti, Ozana ČipčićABSTRACTIn this paper the authors hypothesize that the intensity of subjective experience of vocal fatigue (VF) potentially reflects primary (hyper) functional vocal disorders...
Fri Oct 11, 2019 09:39
The Journal of Nuclear Medicine (JNM) , Preoperative localisation of adenomas in primary hyperparathyroidism: the value of 11C-choline PET/CT in patients with negative or discordant ultrasonography and 99mTc-Sesta-MIBI-SPECT/CTPurpose: We aimed to assess the value of 11C-choline positron emission tomography (PET) in patients with primary hyperparathyroidism (pHPT) with negative or discordant results in methoxyisobutylisonitrile (MIBI) imaging and neck ultrasound. Methods: Eighty-seven patients with...
Fri Oct 11, 2019 09:14
JoVE: Journal of Visualized ExperimentsImpact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of TrainingHere, we present protocols of high-intensity interval and moderate-intensity continuous exercise to observe the response of circulating cardiac troponin T (cTnT) concentration to acute exercise over 10 days. The information may assist with clinical interpretations of post-exercise cTnT elevation and guide the prescription...
Fri Oct 11, 2019 09:13
ScienceDirect Publication: TalantaA new and feasible analytical method using reversed-phase dispersive liquid-liquid microextraction (RP-DLLME) for further determination of Nickel in hydrogenated vegetable fatPublication date: 1 February 2020Source: Talanta, Volume 208Author(s): Daneysa Lahis Kalschne, Cristiane Canan, Murilo Oliveira Beato, Oldair Donizete Leite, Eder Lisandro Moraes FloresAbstractA new and simple method for Ni determination in hydrogenated vegetable fat (HVF) has been developed...
Fri Oct 11, 2019 09:12
AlcoholALCOHOL; +31 new citations31 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: ALCOHOL These pubmed results were generated on 2019/10/10PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.AlcoholThu Oct 10, 2019 05:20ALCOHOL; +31 new citations31...
Fri Oct 11, 2019 09:10
Journal of Neurosurgical Anesthesiology - Effect of General Anesthetics on Caspase-3 Levels in Patients With Aneurysmal Subarachnoid Hemorrhage: A Preliminary StudyBackground: General anesthesia has been associated with neuronal apoptosis and activation of caspases. Apoptosis is a crucial factor in early brain injury following aneurysmal subarachnoid hemorrhage (aSAH). We conducted a double-blind, prospective, randomized pilot study to evaluate the effect of 4 anesthetic agents on cerebrospinal fluid...
Fri Oct 11, 2019 09:09
Allergy , ILC3 Deficiency and Generalized ILC Abnormalities in DOCK8 Deficient PatientsAbstract Background Dedicator of cytokinesis 8 (DOCK8) deficiency is the main cause of the autosomal recessive hyper IgE syndrome (HIES). We previously reported the selective loss of group 3 innate lymphoid cell (ILC) number and function in a Dock8‐deficient mouse model. In this study, we sought to test whether DOCK8 is required for the function and maintenance of ILC subsets in humans. Methods Peripheral blood...
Fri Oct 11, 2019 09:09
Intra-Arterial Injection of Human Adipose-Derived Stem Cells Improves Viability of the Random Component of Axial Skin Flaps in Nude Mice: Skin flap necrosis is a common postoperative complication in reconstructive surgery. Recent evidence suggests that subcutaneously injected adipose-derived stem cells (ASCs) increase the viability of random skin flaps. Here, we examined whether intra-arterial human ASC administration could improve random component survival of axial skin flaps in nude mice.
Fri Oct 11, 2019 09:08
A Novel Way for Upper Eyelid Rejuvenation by Combination of Local Fat-Fascia-Muscle Flap Repositioning for Middle-Aged Asian Women: Upper eyelid aging is common among middle-aged Asians. Apart from skin aging, there has been an increasing recognition for the role of sunken eyelid playing in upper eyelid aging. Various methods have been developed to deal with the upper eyelid volume deflation. However, autologous fat tissue could not achieve stable and satisfying rejuvenation results, especially for...
Fri Oct 11, 2019 09:08
Cancers, Vol. 11, Pages 1531: 99mTc-A1 as a Novel Imaging Agent Targeting Mesothelin-Expressing Pancreatic Ductal AdenocarcinomaCancers, Vol. 11, Pages 1531: 99mTc-A1 as a Novel Imaging Agent Targeting Mesothelin-Expressing Pancreatic Ductal Adenocarcinoma Cancers doi: 10.3390/cancers11101531 Authors: Montemagno Cassim Trichanh Savary Pouyssegur Pagès Fagret Broisat Ghezzi : Mesothelin is a membrane-associated protein overexpressed in pancreatic ductal adenocarcinoma (PDAC). Some mesothelin-targeted...
Fri Oct 11, 2019 09:07
Social Sciences, Vol. 8, Pages 284: The Linguistic Integration of Refugees in ItalySocial Sciences, Vol. 8, Pages 284: The Linguistic Integration of Refugees in Italy Social Sciences doi: 10.3390/socsci8100284 Authors: Bianco Ortiz Cobo The creation of laws regarding the linguistic integration of migrants has contributed to the change in Italian language teaching, which has had to adapt its materials and methodology to migrants. However, the specific case of refugees has not been specifically assessed,...
Fri Oct 11, 2019 09:05
International Journal of Environmental Research and Public HealthIJERPH, Vol. 16, Pages 3830: Characterization of Airborne Particles Emitted During Application of Cosmetic Talc ProductsIJERPH, Vol. 16, Pages 3830: Characterization of Airborne Particles Emitted During Application of Cosmetic Talc Products International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16203830 Authors: Pat E. Rasmussen Christine Levesque Jianjun Niu Howard D. Gardner Gregory Nilsson Kristin Macey...
Fri Oct 11, 2019 09:03
