Lateral semicircular canal-BPPV: Prospective randomized study on the efficacy of four repositioning maneuvers

xlomafota13 shared this article with you from Inoreader Message: https://link.springer.com/article/10.1007/s12070-019-01737-4#:~:text=BPPV%20originating%20from%20stimulation%20of,lateral%20canal%20instead%20of%20the Lateral Semicircular Canal BPPV…Are We Still Ignorant? Jaskaran Singh & Bhanu Bhardwaj Indian Journal of Otolaryngology and Head & Neck Surgery volume 72, pages175–183(2020)Cite this article 137 Accesses Metricsdetails Abstract Benign Paroxysmal Vertigo is one of the most common causes of vertigo. The most common semicircular canal involved in pathogenesis of BPPV is Posterior semicircular canal. However anterior and lateral semicircular canals can also sometimes be responsible for BPPV but their involvement in pathogenesis is still underrated. The incidence of lateral semicircular canal BPPV is in literature is around 10–12% while anterior canal is about 3%. The main objective of this study was to provide the database for incidence of lateral canal BPPV from a tertiary care hospital with the aim that more clinicians incorporate this entity into their differential diagnosis when their cases of posterior canal BPPV are refractory. This was an observational cross-sectional study of 300 patients of BPPV who were coming in ENT OPD as primum or as referral. All the patients underwent both the Dix–Hallpike maneuver as well as the supine roll test. The patients who were having upbeating torsional vertical nyst agmus on Dix–Hallpike were treated on lines of posterior canal BPPV whereas those with horizontal nystagmus on supine roll test were treated on lines of lateral canal BPPV. The data was tabulated and analysed for the incidence of lateral canal BPPV. Out of 300 patients; 188 were males and 122 were females. Most commonly affected age group by BPPV was 40–50 years. Out of 300 cases 260 cases (86.6%) had posterior BPPV and 37 cases (12.3%) had lateral canal BPPV. 3 cases (1%) also had anterior canal BPPV. 30/37 cases of lateral BPPV had geotropic nystagmus while 7 cases had apo-geotropic nystagmus. Posterior canal BPPv was treated by Epleys maneuver. Superior canal BPPV was treated by Yacovino maneuver. The cases of lateral canal BPPV were treated by either Vannucchi-asprella; Gufoni; Lempert maneuver or by the combination of two maneuvers. Lateral canal BPPV is an important diagnosis to consider in all cases of BPPV. Its true incidence is still under blanket as many clinicians are not using supine roll test routinely in their practice while diagnosing BPPV. Many refractory cases of BPPV can be cured if the involvement of other canals in its pathogenesis is kept in the mind so that correct diagnostic and repositioning maneuvers can be applied. We also encourage more institutional studies on lateral canal BPPV so that a standard treatment protocol with clear indications can be designed for this entity as is available for BPPV. This is a preview of subscription content, access via your institution. References 1. Hotson JR, Baloh RW (1998) Acute vestibular syndrome. N Engl J Med 339:680–685 CAS Article Google Scholar 2. Bertholon P, Tringali S, Faye MB, Antoine JC, Martin C (2006) Prospective study of positional nystagmus in 100 consecutive patients. Ann Otol Rhinol Laryngol 115:587–594 Article Google Scholar 3. Barany R (1921) Diagnose von krankheitserscheinungen im. Bereiche des otolithenapparates. Acta Otolaryngol 2:434–437 Article Google Scholar 4. Dix MR, Hallpike CS (1952) The pathology symptomatology and diagnosis of certain common disorders of the vestibular system. Proc R Soc Med 45:341–354 CAS PubMed PubMed Central Google Scholar 5. Schuknecht HF (1969) Cupulolithiasis. Arch Otolaryngol 90:765–778 CAS Article Google Scholar 6. Parnes LS, McClure JA (1992) Free-floating endolymph particles: a new operative finding during posterior semicircular canal occlusion. Laryngoscope 102:988–992 CAS Article Google Scholar 7. McClure JA (1985) Horizontal canal BPV. J Otolaryngol 14:305 Google Scholar 8. Casani AP, Vannucci G, Fattori B, Berrettini S (2002) The treatment of horizontal canal positional vertigo: our experience in 66 cases. Laryngoscope 112:172–178 Article Google Scholar 9. Anagnostou E, Kouzi I, Spengos K (2015) Diagnosis and treatment of anterior-canal benign paroxysmal positional vertigo: a systematic review. J Clin Neurol 11(3):262–267 Article Google Scholar 10. Imai T, Takeda N, Ikezono T, Shigeno K, Asai M, Watanabe Y et al (2017) Classification, diagnostic criteria and management of benign paroxysmal positional vertigo. Auris Nasus Larynx 44:1–6 Article Google Scholar 11. Mandala M (2017) How to diagnose and treat BPPV. In: 3rd Congress of the European Academy of Neurology. Amsterdam 12. Dix MR, Hallpike CS (1952) The pathology, symptomatology and diagnosis of certain common disorders of the vestibular system. Ann Otol Rhinol Laryngol 61(4):987–1016 CAS Article Google Scholar 13. Bhattacharyya N, Gubbels SP, Schwartz SR, Edlow JA, El-Kashlan H, Fife T, Holmberg JM, Mahoney K, Hollingsworth DB, Roberts R, Seidman MD, Prasaad Steiner RW, Tsai Do B, Voelker CC, Waguespack RW, Corrigan MD (2017) Clinical practice guideline: benign paroxysmal positional vertigo (update) executive summary. Otolaryngol Head Neck Surg 156(3):403–416 Article Google Scholar 14. Ranalli P (2019) An overview of central vertigo disorders. Adv Otorhinolaryngol 82:127–133 PubMed Google Scholar 15. Balatsouras DG, Koukoutsis G, Ganelis P, Korres GS, Kaberos A (2011) Diagnosis of single- or multiple-canal benign paroxysmal positional vertigo according to the type of nystagmus. Int J Otolaryngol 2011:483965. https://doi.org/10.1155/2011/483965 Article PubMed PubMed Central Google Scholar 16. Steddin S, Ing D, Brandt T (1996) Horizontal canal benign paroxysmal positioning vertigo (h-BPPV): transition of canalolithiasis to cupulolithiasis. Ann Neurol 40:918–922 CAS Article Google Scholar 17. Shin JE, Jeong KH, Ahn SH et al (2017) Change of nystagmus direction during a head-roll test in lateral semicircular canal cupulolithiasis. Auris Nasus Larynx 44:227–231 Article Google Scholar 18. Choung Y, Shin YR, Kahng H, Park K, Choi SJ (2006) 'Bow and lean test' to determine the affected ear of horizontal canal benign paroxysmal positional vertigo. Laryngoscope 116:1776–1781 Article Google Scholar 19. Lee JB, Han DH, Choi SJ, Park K, Park HY, Sohn IK, Choung Y (2010) Efficacy of the "bow and lean test" for the management of horizontal canal benign paroxysmal positional vertigo. Laryngoscope 120:2339–2346 Article Google Scholar 20. Korres SG, Balatsouras DG, Papouliakos S, Ferekidis E (2007) Benign paroxysmal positional vertigo and its management. Med Sci Monit 13(6):275–282 Google Scholar 21. Califano L, Salafia F, Mazzone S, Melillo MG, Califano M (2014) Anterior canal BPPV and apogeotropic posterior canal BPPV: two rare forms of vertical canalolithiasis. Acta Otorhinolaryngol Ital 34(3):189–197 CAS PubMed PubMed Central Google Scholar 22. Epley JM (1992) The canalith repositioning procedure: for treatment of benign paroxysmal positional vertigo. Otolaryngol Head Neck Surg 107(3):399–404 CAS Article Google Scholar 23. Lempert T, Tiel-Wilck K, Positional A (1996) Maneuver for treatment of horizontal-canal benign positional vertigo. Laryngoscope 106(4):476–478 CAS Article Google Scholar 24. Asprella Libonati G (2005) Diagnostic and treatment strategy of lateral semicircular canal canalolithiasis. Acta Otorhinolaryngol Ital 25(5):277–283 Google Scholar 25. Gufoni M, Mastrosimone L, Di Nasso F (1998) Repositioning maneuver in benign paroxysmal vertigo of horizontal semicircular canal. Acta Otorhinolaryngol Ital 18(6):363–367 CAS PubMed Google Scholar 26. Casani AP, Vannucci G, Fattori B et al (2002) The treatment of horizontal canal positional vertigo: our experience in 66 cases. Laryngoscope 112:172–178 Article Google Scholar 27. Fife TD (1998) Recognition and management of horizontal canal benign paroxysmal positional vertigo. Am J Otol 19:345–351 CAS Article Google Scholar 28. Steenerson RL, Cronin GW, Marbach PM (2005) Effectiveness of treatment techniques in 923 cases of benign paroxysmal positional vertigo. Laryngoscope 115:226–231 Article Google Scholar 29. Honrubia V, Baloh RW, Harris MR et al (1999) Paroxysmal positional vertigo syndrome. Am J Otol 20:465–470 CAS PubMed Google Scholar 30. Macias JD, Lambert KM, Massingale S et al (2000) Variables affecting treatment in benign paroxysmal positional vertigo. Laryngoscope 110:1921–1924 CAS Article Google Scholar 31. Korres SG, Balatsouras DG (2004) Diagnostic, pathophysiologic, and therapeutic aspects of benign paroxysmal positional vertigo. Otolaryngol Head Neck Surg 131:438–444 Article Google Scholar 32. Korres S, Balatsouras DG, Kaberos A, Economou C, Kandiloros D, Ferekidis E (2002) Occurrence of semicircular canal involvement in benign paroxysmal positional vertigo. Otol Neurotol 23(6):926–932 Article Google Scholar 33. Nuti D, Vannucchi P, Pagnini P (2005) Lateral canal BPPV: which is the affected side? Audiol Med 3(1):16–20 Article Google Scholar 34. Bertholon P, Faye MB, Tringali S et al (2002) Benign paroxysmal positional vertigo of the horizontal canal. Clinical features in 25 patients. Ann Otolaryngol Chir Cervicofac 119:73–80 CAS PubMed Google Scholar 35. Waespe W (1997) Benign positional vertigo and nystagmus of the horizontal semicircular canal. Schweiz Med Wochenschr 127:287–295 CAS PubMed Google Scholar 36. Vannucchi P, Pecci R (2011) About nystagmus transformation in a case of apogeotropic lateral semicircular canal benign paroxysmal positional vertigo. Int J Otolaryngol 2011:4. https://doi.org/10.1155/2011/687921 Article Google Scholar 37. Kurtzer DA, Gans RE, McLeod H (2017) New horizontal canal benign paroxysmal positional vertigo treatment: kurtzer hybrid maneuver. Glob J Otol 6(3):555686. https://doi.org/10.19080/GJO.2017.06.555686 Article Google Scholar 38. Bhattacharyya N, Gubbels SP, Schwartz SR, Edlow JA, El-Kashlan H, Fife T, Corrigan MD (2017) Clinical practice guideline: benign paroxysmal positional vertigo (update). Otolaryngol Head Neck Surg 156(3):S1–S47 Article Google Scholar 39. Fife TD, Iverson DJ, Lempert T, Furman JM, Baloh RW, Tusa RJ et al (2008) Practice parameter: therapies for benign paroxysmal positional vertigo (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 70:2067–2074 CAS Article Google Scholar 40. Nuti D, Mandalà M, Salerni L (2009) Lateral canal paroxysmal positional vertigo revisited. Ann NY Acad Sci 1164:316–323 Article Google Scholar 41. Tirelli G, Russolo M (2004) 360-Degree canalith repositioning procedure for the horizontal canal. Otolaryngol Head Neck Surg 131:740–746 Article Google Scholar 42. Chiou WY, Lee HL, Tsai SC, Yu TH, Lee XX (2005) A single therapy for all subtypes of horizontal canal positional vertigo. Laryngoscope 115:1432–1435 Article Google Scholar Download references Author information Affiliations Sri Guru Ram Das Institute of Health Sciences and Research, Amritsar, India Jaskaran Singh & Bhanu Bhardwaj Mohali, India Jaskaran Singh Amritsar, India Bhanu Bhardwaj Corresponding author Correspondence to Bhanu Bhardwaj. Ethics declarations Conflict of interest The authors declare that they have no conflict of interest. Ethical Approval Before starting the study Ethical Clearance was taken from the institutional ETHICAL Committee as per DECLARATION OF HELSINKI. Informed consent Informed consent was duly taken from all the patients. Additional information Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Rights and permissions Reprints and Permissions About this article Verify currency and authenticity via CrossMark Cite this article Singh, J., Bhardwaj, B. Lateral Semicircular Canal BPPV…Are We Still Ignorant?. Indian J Otolaryngol Head Neck Surg 72, 175–183 (2020). https://doi.org/10.1007/s12070-019-01737-4 Download citation Received 06 September 2019 Accepted 09 September 2019 Published 26 September 2019 Issue Date June 2020 DOI https://doi.org/10.1007/s12070-019-01737-4 Keywords Horizontal canal BPPV Lateral canal BPPV Geotropic nystagmus Apo-geotropic nystagmus Supine roll test Bow and bean test Vannucchi asprella maneuver Gufoni maneuver Lempert maneuver Lateral semicircular canal-BPPV: Prospective randomized study on the efficacy of four repositioning maneuvers Via Acta Otorrinolaringológica Española Publication date: Available online 23 January 2021 Source: Acta Otorrinolaringológica Española Author(s): Filipe Correia, Luís Castelhano, Pedro Cavilhas, Pedro Escada View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Therapeutic options in Meniere's disease: Our experience

xlomafota13 shared this article with you from Inoreader Message: Arch Otolaryngol 1977 Oct;103(10):589-93. doi: 10.1001/archotol.1977.00780270057007. Therapeutic options in Meniere's disease I K Arenberg, R F Bayer PMID: 303093 DOI: 10.1001/archotol.1977.00780270057007 Emphasis on treatment in Meniere's disease has recently shifted from a concentration on the vertiginous component alone to include conservation or improvement of hearing as well. This presentation tabulates the current otological literature's reports of both the medical and surgical options available in the treatment of Meniere's disease. The authors conclude that these more recent reports deemphasize the importance of the vertiginous component, while emphasizing the importance of the hearing component in evaluation of the efficacy of any therapeutic modality. Furthermore, these reports indicate that endolymphatic sac decompression and drainage surgery alone offers a considerable chance for conservation or improvement in hearing, as well as relief of vertigo in early cases of reversible, fluctuating hearing deficits. In nonreversible or nonfluctuating hearing deficits with hearing worth conserving, vestibular neurectomy with excision of Scarpa's ganglion yields the best results. Therapeutic options in Meniere's disease: Our experience Via American Journal of Otolaryngology Publication date: Available online 23 January 2021 Source: American Journal of Otolaryngology Author(s): Pietro De Luca, Claudia Cassandro, Massimo Ralli, Arianna Di Stadio, Pasquale Viola, Ettore Cassandro, Alfonso Scarpa View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Do collagen‐related diseases represent a risk factor for hidradenitis suppurativa?

xlomafota13 shared this article with you from Inoreader Do collagen‐related diseases represent a risk factor for hidradenitis suppurativa? Via Experimental Dermatology Abstract We read with great interest the work of Boer et al [1] that explores the role of mechanical stress as a potential triggering factor for hidradenitis suppurativa (HS). The authors reported two cases of patients who developed HS along the striae distensae (SD). The hypothesis proposed by the authors to explain this ectopic lesions is the fact that SD are characterized by a decrease of dermal thickness due to destruction of collagen fibres which may reduce the mechanical support to the pilosebaceous structures and if combined to frictional forces, may trigger the onset of HS by promoting skin inflammation. Matrix metalloproteinases (MMPs) are proteases able to degrade the major components of the extracellular matrix (ECM). View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A narrative review of pharmacologic treatments for COVID‐19: safety considerations and ototoxicity

xlomafota13 shared this article with you from Inoreader A narrative review of pharmacologic treatments for COVID‐19: safety considerations and ototoxicity Via The Laryngoscope Abstract Objectives The purpose of this review is to summarize evidence‐based data regarding the ototoxic effects of potential COVID‐19 therapeutics to treat patients suffering from SARS‐CoV‐2. Methods Medications under investigation as novel therapeutics to treat COVID‐19 were identified using the search term coronavirus therapeutics, COVID therapeutics and SARS‐CoV‐2 therapeutics on ClinicalTrials.gov and the PubMed Database. A literature review was performed using the PubMed Database for each proposed COVID‐19 therapeutic to identify relevant articles. Search criteria included Medical Subject Headings (MeSH) and key word search terms for ototoxicity, vestibulotoxicity, hearing disorders and vertigo. Results Six proposed COVID‐19 therapeutics were identified as possessing ototoxic side effects including chloroquine and hydroxychloroquine, azithromycin, lopinavir‐ritonavir, interferon, ribavirin and ivermectin. Conclusions Available evidence suggests that ototoxic effects may be improved or mitigated by stopping the offending agent. Recognition of hearing loss, tinnitus or imbalance/vertigo is therefore crucial to facilitate early intervention and prevent long‐term damage. Hospitals should consider the inclusion of audiologic monitoring protocols for patients receiving COVID‐19 therapeutics with known ototoxicity, especially in high risk patient groups such as the elderly and hearing impaired. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

End‐of‐Life Practice Patterns in Head and Neck Cancer

xlomafota13 shared this article with you from Inoreader End‐of‐Life Practice Patterns in Head and Neck Cancer Via The Laryngoscope Objective/Hypothesis Despite the importance of symptom management and end‐of‐life (EOL) care in head and neck cancers (HNC), there is little literature on care practices in this population. This study examines EOL care practice patterns using nationally established metrics. Study Design Retrospective chart review. Methods Review of HNC patients who were actively followed and treated (defined as one clinic note within 90 days, two within preceding 9 months, and having received treatment at our institution) and died between January 1, 2017 and December 31, 2018. The cohort was reviewed for performance on Quality Oncology Practice Initiative (QOPI®) and other metrics. Results Of 133 patients identified, 52 met inclusion criteria. The average age at death was 69.8 years. About 59% had distant metastases, 30% had locoregional disease, 11% were undergoing primary treatment. Twenty‐three percentage received chemotherapy within the last 14 days of life. Fifty percentage of patients were admitted in the last 30 days of life, and 33% died in the hospital. Fifty‐four percentage of patients had either Physician Orders for Life‐Sustaining Treatment or Advanced Directive on file. Eighty‐one percentage of patients had any type of goals of care discussion documented. Sixty‐five percentage of all patients received referrals to palliative care and 46% of all patients enrolled in hospice. The median days in hospice was 12. Having a goals of care discussion was significantly associated with utilization of palliative and hospice care. Conclusions Provider‐documented goals of care discussions were strongly correlated to referrals and enrollment in palliative and hospice care. Areas for improvement include better documentation of treatment directives and reducing low‐utility treatments. Level of Evidence 4 Laryngoscope, 2021 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

An Unusual Delayed Complication of Rib Graft Microtia Reconstruction After Two Decades: A Case Report

xlomafota13 shared this article with you from Inoreader An Unusual Delayed Complication of Rib Graft Microtia Reconstruction After Two Decades: A Case Report Via Otolaryngology Indian Abstract Microtia comprises a spectrum of congenital malformation characterized by partial deformities of the auricular components to complete absence of pinna. Surgical reconstructions of this anomaly are often complex and technically challenging. Infection, hematoma, and skin necrosis with resultant exposed cartilage graft tend to occur in the early phase of post-operative care. Herein, we report a case of a spontaneous auricular abscess with exposed cartilage framework 20 years following rib cartilage reconstruction. To our knowledge, this is the first case of such an occurrence. The treatment options are discussed, along with the review of the literature. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Using Interleaved Stimulation to Measure the Size and Selectivity of the Sustained Phase-Locked Neural Response to Cochlear Implant Stimulation

xlomafota13 shared this article with you from Inoreader Using Interleaved Stimulation to Measure the Size and Selectivity of the Sustained Phase-Locked Neural Response to Cochlear Implant Stimulation Via Journal of the Association for Research in Otolaryngology Abstract We measured the sustained neural response to electrical stimulation by a cochlear implant (CI). To do so, we interleaved two stimuli with frequencies F1 and F2 Hz and recorded a neural distortion response (NDR) at F2-F1 Hz. We show that, because any one time point contains only the F1 or F2 stimulus, the instantaneous nonlinearities typical of electrical artefact should not produce distortion at this frequency. However, if the stimulus is smoothed, such as by charge integration at the nerve membrane, subsequent (neural) nonlinearities can produce a component at F2-F1 Hz. We stimulated a single CI electrode with interleaved sinusoids or interleaved amplitude-modulated pulse trains such that F2 = 1.5F1, and found no evidence for an NDR when F2-F1 was between 90 and 120 Hz. However, interleaved amplitude-modulated pulse trains with F2-F1~40 Hz revealed a substantial NDR with a group delay of about 45 ms, consistent with a thalamic a nd/or cortical response. The NDR could be measured even from recording electrodes adjacent to the implant and at the highest pulse rates (> 4000 pps) used clinically. We then measured the selectivity of this sustained response by presenting F1 and F2 to different electrodes and at different between-electrode distances. This revealed a broad tuning that, we argue, reflects the overlap between the excitation elicited by the two electrodes. Our results also provide a glimpse of the neural nonlinearity in the auditory system, unaffected by the biomechanical cochlear nonlinearities that accompany acoustic stimulation. Several potential clinical applications of our findings are discussed. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Prolonged Use of n95 Mask a Boon or Bane to Healthcare Workers During Covid–19 Pandemic

xlomafota13 shared this article with you from Inoreader Prolonged Use of n95 Mask a Boon or Bane to Healthcare Workers During Covid–19 Pandemic Via Otolaryngology Indian Abstract The novel coronavirus, referred to as SARS-COV 2, originated in Wuhan, China in December 2019. Since many Health Care Workers (HCW) and general public lost their lives. The only thing which can prevent from being infected is social distancing and wearing of mask (N95) and wearing of mask has its own adverse effects. This is a retrospective study conducted in the Department of Otorhinolaryngology, Hind Institute of Medical Sciences, Sitapur from April 2020 to August 2020. The most common symptoms of wearing mask were headache, nasal dryness, eye dryness and acne for which extra precautions to be taken to deal with these conditions during COVID–19 pandemic. HCW should wear mask to prevent from exposing but while using the mask there are certain prerequisites which has to be followed to prevent from not only thr COVD – 19 but also the complications of prolonged use of N95 mask. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Immune-related Bell’s palsy in melanoma patients treated with immune checkpoint inhibitors

xlomafota13 shared this article with you from Inoreader Immune-related Bell's palsy in melanoma patients treated with immune checkpoint inhibitors Via Melanoma Research - Published Ahead-of-Print Immune-checkpoint inhibitors (ICIs) exposed the oncology community to novel immune-related adverse events (irAEs). Here, we report on a retrospective analysis of patients with melanoma who developed an ICI-related, unilateral, acute and peripheral facial nerve paralysis (Bell's palsy).We retrospectively reviewed a ll the cases of ICI-related Bell's palsy in patients with melanoma treated at our institution from January 2015 to January 2020. A total of five cases of ICI-related Bell's palsy were identified. Median age was 63 years. Median time-to-onset of Bell's palsy from ICIs initiation was 15 weeks. Four patients were treated with prednisone alone, whereas one patient was treated with prednisone plus valaciclovir. All the patients completely recovered from Bell's palsy without neurological sequelae. In melanoma patients treated with ICIs, Bell's palsy is a rare, neurologic irAE with a favorable outcome following administration of oral corticosteroids. Received 12 November 2020 Accepted 29 December 2020 Correspondence to Carolina Cimminiello, MD, Department of Medical Oncology and Hematology, Melanoma Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian, 1 – 20133, Milan, Italy, Tel: +39 02 2390 3823; e-mail: carolina.cimminiello@istitutotumori.mi.it Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Diagnostic and prognostic value of heat shock protein 90α in malignant melanoma

xlomafota13 shared this article with you from Inoreader Diagnostic and prognostic value of heat shock protein 90α in malignant melanoma Via Melanoma Research - Published Ahead-of-Print Malignant melanoma is one of the most common tumours of the skin. Heat shock protein 90α (HSP90α) has been applied in the auxiliary diagnosis of various malignancies, as a tumour marker. This study aims to evaluate diagnostic, therapeutic efficacy and prognostic value of plasma HSP90α levels in malignant melanoma. In this study, higher plasma HSP90α levels and abnormal rates were found in malignant melanoma patients than in healthy controls (92.63 vs. 51.84 ng/mL; P  4 mm, a high Clark level (IV + V), abnormal serum lactate dehydrogenase (LDH), distant metastases occurrence and Ki-67≥30% (P  View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.