Primary diffuse large B-cell lymphoma of the major salivary glands: Increasing incidence and survival

Greek DailyNews shared this article with you from Inoreader Primary diffuse large B-cell lymphoma of the major salivary glands: Increasing incidence and survival Via American Journal of Otolaryngology Publication date: Available online 28 January 2021 Source: American Journal of Otolaryngology Author(s): Avigeet Gupta, Joshua A. Lee, Shaun A. Nguyen, Eric J. Lentsch View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Why Clinicians Choose Their Language Intervention Approach: An International Perspective on Intervention for Children with Developmental Language Disorder

Greek DailyNews shared this article with you from Inoreader Why Clinicians Choose Their Language Intervention Approach: An International Perspective on Intervention for Children with Developmental Language Disorder Via Folia Phoniatrica et Logopaedica Purpose: Considerable progress has been made in recent years in generating external evidence underpinning interventions for children with developmental language disorder (DLD), but less is known about the practitioner decision-making process underpinning such interventions and whether such decisions are context specific or are internationally generalizable. Methods: An online survey about clinical practice was developed by members of COST Action IS1406, an EU-funde d research network, which included representation from 39 countries. The participants were 2,408 practitioners who answered questions in relation to their decision making for a specific child of their choosing with DLD. Analysis of open-ended questions was undertaken, and data were converted into codes for the purpose of quantitative analysis. Results: Although a wide range of intervention approaches and rationales were reported, the majority of responses referenced a client-centred approach. Level of functioning was used as a rationale only if a child had severe DLD. Practitioners with university level education or above were less likely to report basing intervention on client-centred factors. A number of differently named interventions with variable theoretical and empirical underpinnings were used in different countries. Conclusions: Specific client and practitioner characteristics have an impact on the intervention approaches and rationales adopted ac ross countries. A limited number of practitioners reported use of external scientific evidence, which suggests that there should be more initiatives in basic training of practitioners and continuing professional development to encourage the uptake of scientific evidence-based practice. Folia Phoniatr Logop View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Biomarkers in atopic dermatitis - a review on behalf of the international eczema council

Greek DailyNews shared this article with you from Inoreader Biomarkers in atopic dermatitis - a review on behalf of the international eczema council Via Journal of Allergy and Clinical Immunology Atopic dermatitis (AD) is a common yet complex skin disease, posing a therapeutic challenge with increasingly recognized different phenotypes among variable patient populations. As therapeutic response may vary based on the heterogenous clinical and molecular phenotypes, a shift towards precision medicine approaches may improve AD management. Herein we will consider biomarkers as potential instruments in the toolbox of precision medicine in AD and will review the process of biomarker development and validation, the opinion of AD experts on the use of biomarkers, types of biomarkers, encompassing biomarkers that may improve AD diagnosis, biomarkers reflecting disease severity, and those potentially predicting AD development, concomitant atopic diseases or therapeutic response, and current practice of biomarkers in AD. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Skin-resident natural killer T cells participate to cutaneous allergic inflammation in atopic dermatitis

Greek DailyNews shared this article with you from Inoreader Skin-resident natural killer T cells participate to cutaneous allergic inflammation in atopic dermatitis Via Journal of Allergy and Clinical Immunology Skin-resident CXCR4+ NKT cells have a role in atopic dermatitis. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Acute Laryngeal Injury After Intubation

Greek DailyNews shared this article with you from Inoreader Acute Laryngeal Injury After Intubation Via JAMA Otolaryngology–Head & Neck Surgery Online First Although intubation is often necessary and lifesaving, there are known laryngotracheal consequences. Otolaryngologists are all too familiar with the vocal-fold damage and inflammatory conditions that are associated with prolonged intubation because patients often present in the hospital or clinic with dysphonia or dyspnea. The size of the endotracheal tube and the duration of intubation are known to be risk factors for postintubation damage. The pathophysiology is well understood to be caused by pressure-induced damage to the mucosal and car tilaginous structures of the larynx. However, despite this knowledge, laryngeal damage is often considered unavoidable, accrued as a result of a lifesaving stay in an intensive care unit. The resulting disease state can be so functionally devastating and difficult to treat that many otolaryngologists are left wondering: is there something we can do to prevent this from happening? View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Early Intervention for the Treatment of Acute Laryngeal Injury After Intubation

Greek DailyNews shared this article with you from Inoreader Early Intervention for the Treatment of Acute Laryngeal Injury After Intubation Via JAMA Otolaryngology–Head & Neck Surgery Online First This cohort study compares functional outcomes between early and late inter vention for patients with intubation-related laryngeal injury. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

De Novo vs Inverted Papilloma–Associated Sinonasal Squamous Cell Carcinoma Survival Outcomes

Greek DailyNews shared this article with you from Inoreader De Novo vs Inverted Papilloma–Associated Sinonasal Squamous Cell Carcinoma Survival Outcomes Via JAMA Otolaryngology–Head & Neck Surgery Online First This systematic review and meta-analysis uses data from studies retrieved f rom an Ovid Medline, Embase, Scopus, and Cochrane Library database search to investigate survival differences between de novo and inverted papilloma–associated sinonasal squamous cell carcinoma pathogenesis. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Prevalence of anemia among patients with solid cancers at diagnosis

Greek DailyNews shared this article with you from Inoreader Prevalence of anemia among Saudi patients with solid cancers at diagnosis in King Faisal Hospital, Taif Province, Kingdom of Saudi Arabia Via Head and neck cancers by Mazen Almehmadi, Magdi Salih, Tariq E. Elmissbah, Abdulaziz Alsharif, Naif Alsiwiehri, Khalid Alzahrani, Alaa Shafie, Haytham Dahlawi Objectives The aim of this study was to estimate the prevalence of anemia among patients newly diagnosed with solid malignancies at King Faisal Hospital in Taif Province, Kingdom of Saudi Arabia. Methods A descriptive, cross-sectional, hospital-based study was conducted from December 2017 to March 2020. A total of 320 patients newly diagnosed with solid malignancy were examined to assess anemia prevalence. Results Of 320 patients with solid cancers, 245 (76.6%) were female and 75 (23.4%) were male. The median (interquartile range) age of 57 (45 ─ 66) years, range between 16 and 108 years. The types of cancer included were breast (29.1%), female genital tract (20.0%), colorectal (25.3%), head and neck (10.3%), urinary bladder (4.7%), prostate (5.0%), lung (2.5%), liver (2.2%) and lymphoma (0.9%). The prevalence of anemia at diagnosis of cancer was 44.1% across all cancer types. A higher anemia prevalence was noted in colorectal (n = 46/81, 56.8%) (p = 0.047). Conclusion Patients with colorectal or female genital tract cancers had a higher anemia prevalence (56.8% and 43.8%, respectively) than did patients with other cancers. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The Possible Role of Sclerostin in the Pathogenesis of Tympanosclerosis

Greek DailyNews shared this article with you from Inoreader The Possible Role of Sclerostin in the Pathogenesis of Tympanosclerosis Via AUD : Last 10 articles Objective: The aim of this study was to investigate sclerostin (SOST) expression in a rat model of experimental tympanosclerosis (TS) and its possible role in the formation of TS. Materials and Methods: Thirty-four SD rats were randomly divided into 2 groups: experimental group (n = 17) and normal group (n = 17). The left tympanic cavities in the experimental group were inoculated with methicillin-resistant Staphylococcus aureus. The changes of t ympanic membranes were examined and recorded under otoendoscope. Haematoxylin-eosin staining was adopted to detect the morphological changes in the tympanic membrane and middle ear mucosa. Immunohistochemistry and Western blot analysis were used to observe the expression of SOST, Wnt3a, β-catenin, and P-ERK1/2. Results: In the experimental group, sclerotic lesions were observed in 54.5% ears in the end of 6 weeks. Morphological changes such as mucosa incrassation, inflammatory cells infiltration, fibrous tissue proliferation, and interstitial tissue incrassation prominently appeared in the tympanic membrane and middle ear mucosa. SOST protein was mainly distributed in the cytoplasm of epithelial cells and gland cells, the expression of which increased significantly in the calcified experimental ears. In addition, expression levels of Wnt3a, β-catenin, and P-ERK1/2 increased significantly in the calcified group too. Conclusion: The upregulated expression level of SOST may be involved in the formation of TS, first, through the pro-phosphorylation of ERK1/2 in the inflammatory stage, and then through the enhancement of Wnt3a in the osteogenic stage. Audiol Neurotol View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Stem Cells and Gene Therapy in Progressive Hearing Loss: the State of the Art

Greek DailyNews shared this article with you from Inoreader Stem Cells and Gene Therapy in Progressive Hearing Loss: the State of the Art Via Journal of the Association for Research in Otolaryngology Abstract Progressive non-syndromic sensorineural hearing loss (PNSHL) is the most common cause of sensory impairment, affecting more than a third of individuals over the age of 65. PNSHL includes noise-induced hearing loss (NIHL) and inherited forms of deafness, among which is delayed-onset autosomal dominant hearing loss (AD PNSHL). PNSHL is a prime candidate for genetic therapies due to the fact that PNSHL has been studied extensively, and there is a potentially wide window between identification of the disorder and the onset of hearing loss. Several gene therapy strategies exist that show potential for targeting PNSHL, including viral and non-viral approaches, and gene editing versus gene-modulating approaches. To fully explore the potential of these therapy strategies, a faithful in vitro model of the human inner ear is needed. Such models may come from induced pluripotent stem cells (iPSCs). The development of new treatment modalities by combining iPSC modeling with novel and innovative gene therapy approaches will pave the way for future applications leading to improved quality of life for many affected individuals and their families. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

5 things to know about capnography and respiratory distress

Greek DailyNews shared this article with you from Inoreader 5 things to know about capnography and respiratory distress Via Airway Management RSS Feed Understand how monitoring end-tidal carbon dioxide helps assess and treat a patient in respiratory distress Attachments: View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.