Associations Between Tinnitus and Mental Health in Middle-aged and Elderly Persons

xlomafota13 shared this article with you from Inoreader Associations Between Tinnitus and Mental Health in Middle-aged and Elderly Persons Via JAMA Otolaryngology–Head & Neck Surgery Current Issue This cohort study with cross-sectional analyses and 4-year follow-up assesses whether the presence of tinnitus that interferes or does not interfere with daily life is associated with symptoms of depression, anxiety, or poor sleep quality in a population-based sample of individuals 40 years or older who reside in the Netherlands. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Aberrant Hypoglossal Nerve During Neck Dissection

xlomafota13 shared this article with you from Inoreader Aberrant Hypoglossal Nerve During Neck Dissection Via JAMA Otolaryngology–Head & Neck Surgery Current Issue This case report describes a woman in her 50s who presented with a right buccal squamous cell carcinoma and was found to have an abnormal course of the hypoglossal nerve. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Early Intervention for the Treatment of Acute Laryngeal Injury After Intubation—Excellent Outcomes With Low Risk?—Reply

xlomafota13 shared this article with you from Inoreader Early Intervention for the Treatment of Acute Laryngeal Injury After Intubation—Excellent Outcomes With Low Risk?—Reply Via JAMA Otolaryngology–Head & Neck Surgery Current Issue In Reply Aretha et al offer support for our recent observations detailing the importance of early intervention for the treatment of acute laryngeal injury after prolonged mechanical ventilation. In addition, the authors raise several good points that will shape future questions surrounding laryngeal functional recovery after critical illness. Their letter also highlights the inherent limitations involved in a retrospective cohort study. These limitations are salient, as evidenced by their mention and thorough discussion in our initial manuscript. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Normative and Pathological Ranges of Cervical Vestibular Evoked Myogenic Potentials in Normal Subjects and Patients with Complete Compensated Unilateral Vestibular Loss: A Cross Sectional Study

xlomafota13 shared this article with you from Inoreader Normative and Pathological Ranges of Cervical Vestibular Evoked Myogenic Potentials in Normal Subjects and Patients with Complete Compensated Unilateral Vestibular Loss: A Cross Sectional Study Via Otolaryngology Indian Abstract To know the normative ranges of VEMP response metrics in healthy young adults. To know the pathological cutoff of VEMP metrics in unilateral vestibular loss patients. To compare our VEMP metrics with the normative values of other studies from the western world. Prospective cross-sectional study. Tertiary care audiovestibular laboratory. 30 healthy subjects and 15 cases with a unilateral complete compensated loss. Various VEMP parameters-p1 latency, n1 latency, p1-n1 amplitude and Interaural asymmetry ratio (IAR) were entered into databases and analyzed. We compared our parameters with the most cited scientific data on VEMP available in the PubMed database, and we analyzed the results. 90% of controls and 80% of cases got VEMP responses at 95 dB HL threshold, 500 Hz with subject/patient placed in sitting upright with head turned to opposite side position. The normative data of VEMP response metrics in young adults for p1, n1 latencies, p1-n1 amplitude , and IAR are 13 ± 2 ms, 21 ± 2 ms, 91 ± 33 uV, and 9.25 ± 7.3, respectively. As the VEMP test has 100% sensitivity and 100% (95% CI 87–100%) negative predictive value in detecting the saccular dysfunction, we recommend the VEMP test as a mandatory tool in the vestibular test battery. There is no statistically significant difference in various VEMP parameters between the control and normal sides of the case group. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Middle Fossa Encephaloceles Treated via the Transmastoid Approach: A Case Series and Review of the Literature

xlomafota13 shared this article with you from Inoreader Middle Fossa Encephaloceles Treated via the Transmastoid Approach: A Case Series and Review of the Literature Via leak of cerebrospinal fluid Oper Neurosurg (Hagerstown). 2021 Aug 12:opab276. doi: 10.1093/ons/opab276. Online ahead of print. ABSTRACT BACKGROUND: Middle fossa (MF) encephaloceles are rare lesions resulting from herniation through defects in the tegmen tympani or mastoideum. Underlying etiologies and clinical presentations are variable. Surgical goals include fistula obliteration, resection of nonfunctioning parenchyma, and dehiscence repair. The middle cranial fossa approach (MCFA), transmastoid approach (TMA), and combined (MCFA + TMA) approaches have been described. The minimally invasive TMA provides excellent exposure of the pathology and allows for ample working room to repair the defect. OBJECTIVE: We present short-term follow-up results in patients treated via the TM repair at our institution. METHODS: A retrospective review of patients with symptomatic encephaloceles treated via the TMA by our multidisciplinary team. Patient demographics, clinical presentations, intraoperative findings, repair technique, and outcomes were highlighted. RESULTS: A total of 16 encephaloceles in 13 patients were treated. Defect etiologies included spontaneous (50.0%), secondary to chronic infection (25.0%), or cholesteatoma (18.8%). Defects were most often within the tegmen mastoideum (68.8%). Average length of surgery was 3.3 h (95% CI: 2.86-3.67) and length of stay 3.9 d (95% CI: 3.09-4.79). On short-term follow-up (average 11.5 mo), no patients experienced postoperative cerebrospinal fluid leak or recurrence. The majority of patients (83.3%) experienced confirmed improvement or stabilization of hearing. CONCLUSION: MF encephaloceles present with various clinical manifestations and result from multiple underlying etiologies. The TMA is an alternative to craniotomy and our short-term results suggest that this approach may be utilized effectively in appropriately selected cases. PMID:34382089 | DOI:10.1093/ons/opab276 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A Chinese survey on clinical practice in hyperthyroidism management: comparison with recent studies and guidelines

xlomafota13 shared this article with you from Inoreader A Chinese survey on clinical practice in hyperthyroidism management: comparison with recent studies and guidelines Via radioactive iodine Endocr Connect. 2021 Aug 1:EC-21-0340.R1. doi: 10.1530/EC-21-0340. Online ahead of print. ABSTRACT OBJECTIVE: To conduct a questionnaire survey of the current clinical practice for overt hyperthyroidism in China. METHODS: An online questionnaire survey was conducted in July 2020. The two questionnaires covered 35 and 8 questions about nonpregnancy and pregnancy clinical practice for overt hyperthyroidism, respectively. RESULTS: One thousand, two hundred fifty-six physic ians participated. Chief physicians and associate chief physicians accounted for 58.6% of the participants. Approximately 95.2% of the respondents chose the thyrotropin receptor antibody (TRAb) test to clarify the etiology of thyrotoxicosis, while only 27.0% of them chose radioactive iodine uptake (RAIU). In terms of the treatment for nonpregnant patients, antithyroid drugs (ATDs) were the first choice, and most of the clinicians chose methimazole. Compared with clinicians in recent studies, Chinese physicians used serum TRAb to diagnose Graves' disease more commonly, and there were obviously more physicians preferring ATDs. For maternal hyperthyroidism, most physicians preferred propylthiouracil administration before or during the first trimester, which is consistent with the 2016 American Thyroid Association (ATA) guidelines. In terms of the initial ATD dose, monitoring of the treatment process, indications for ATD withdrawal, and treatment of special cases, the preferences of Chi nese physicians were generally consistent with the guidelines. CONCLUSION: Chinese physicians can generally follow the ATA guidelines for the diagnosis and treatment of hyperthyroidism. Moreover, there are small differences from foreign studies or the guidelines with respect to particular problems. These findings provide evidence for future clinical research in China. PMID:34382578 | DOI:10.1530/EC-21-0340 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Multifunctional Hybrid Hydrogel Enhanced Antitumor Therapy through Multiple Destroying DNA Functions by a Triple-Combination Synergistic Therapy

xlomafota13 shared this article with you from Inoreader Multifunctional Hybrid Hydrogel Enhanced Antitumor Therapy through Multiple Destroying DNA Functions by a Triple-Combination Synergistic Therapy Via radioactive iodine Adv Healthc Mater. 2021 Aug 12:e2101190. doi: 10.1002/adhm.202101190. Online ahead of print. ABSTRACT Brachytherapy, as an effective setting for precise cancer therapy in clinic, can lead to serious DNA damage. However, its therapeutic efficacy is always limited by the DNA self-repair property, tumor hypoxia-associated radiation resistance as well as inhomogeneous distribution of the radioactive material. Herein, a multifunctional hybrid hydrogel (131 I-hydrogel/DOX/GNPs aggregates) is developed by loading gold nanoparticle aggregates (GNPs aggregates) and DOX into a radionuclide iodine-131 (131 I) labelled polymeric hydrogels (131 I-PEG-P(Tyr)8 ) for tumor destruction by completely damaging DNA self-repair functions. This hybrid hydrogel exhibits excellent photothermal/radiolabel stability, biocompatibility, and fluorescence/photothermal /SPECT imaging properties. After local injection, the sustained releasing DOX within tumor greatly inhibits the DNA replication. Meanwhile, GNPs aggregates as a radiosensitizer and photosensitizer show a significant improvement of brachytherapeutic efficacy and cause serious DNA damage. Simultaneously, GNPs aggregates induce mild photothermal therapy under 808 nm laser irradiation, which not only inhibits self-repair of the damaged DNA but also effectively relieves tumor hypoxic condition to enhance the therapeutic effects of brachytherapy, leading to a triple-synergistic destructi on of DNA functions. Therefore, this study provides a highly efficient tumor synergistic therapy platform and insight into the synergistic antitumor mechanism in DNA level. PMID:34382378 | DOI:10.1002/adhm.202101190 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Pharyngeal Lipoma–A Potentially Life Threatening Presentation

xlomafota13 shared this article with you from Inoreader Pharyngeal Lipoma–A Potentially Life Threatening Presentation Via Otolaryngology Indian Abstract Pharyngeal lipoma of the upper aero-digestive system is extremely rare. It is typically benign, slow growing and symptoms would depend on its size and location. Surgical intervention is often needed especially for large tumour with impending airway obstruction. Here we present a case of potentially life threatening presentation of pharyngeal lipoma. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Physical Abuse Creating Cauliflower Ear in an Infant: A Discussion of Mechanism and Review of the Literature

xlomafota13 shared this article with you from Inoreader Physical Abuse Creating Cauliflower Ear in an Infant: A Discussion of Mechanism and Review of the Literature Via Otolaryngology Indian Abstract We evaluated an infant with flagrantly abusive injury. However, he had a history of prior isolated ear hematoma that was not properly recognized as a sign of trauma, harshly illustrating a missed opportunity when early diagnosis may have prevented escalating abusive injury. In addition, we reviewed and summarized the last two decades of literature related to this topic to better understand previously described findings in similar populations; these were scant. This case report emphasizes the importance of detecting sentinel injuries that forebode child maltreatment. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Association between obstructive sleep apnea and thyroid cancer incidence: a national health insurance data study

xlomafota13 shared this article with you from Inoreader Association between obstructive sleep apnea and thyroid cancer incidence: a national health insurance data study Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Aug 12. doi: 10.1007/s00405-021-07028-5. Online ahead of print. NO ABSTRACT PMID:34383121 | DOI:10.1007/s00405-021-07028-5 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Population exposure-response model of 131I in patients with benign thyroid disease

xlomafota13 shared this article with you from Inoreader Population exposure-response model of <sup>131</sup>I in patients with benign thyroid disease Via radioactive iodine Eur J Pharm Sci. 2021 Oct 1;165:105942. doi: 10.1016/j.ejps.2021.105942. Epub 2021 Jul 14. ABSTRACT PURPOSE: The study aimed to explore the relationship of different exposure measures with 131I therapy response in patients with benign thyroid disease, estimate the variability in the response, investigate possible covariates, and discuss dosing implications of the results. METHODS: A population exposure-response analysis was performed using nonlinear mixed-effects m odelling. Data from 95 adult patients with benign thyroid disease were analysed. Evaluated exposure parameters were: administered radioactivity dose (Aa) [MBq], total absorbed dose (ABD) [Gy], maximum of absorbed dose-rate (MXR) [Gy/h] and biologically effective dose (BED) [Gy]. The response was modelled as ordered categorical data: hyper-, eu- and hypothyroidism. The final model performance was evaluated by a visual predictive check. RESULTS: The probability of the outcome following 131I therapy was best described by a proportional-odds model, including the log-linear model of 131I effect and the exponential model of the response-time relationship. All exposure measures were statistically significant with p<0.001, with BED and ABD being statistically better than the other two. Nevertheless, as BED resulted in the lowest AIC value, it was included in the final model. Accordingly, BED value of 289.7 Gy is associated with 80% probability of successful tr eatment outcome 12 months after 131I application in patients with median thyroid volume (32.28 mL). The target thyroid volume was a statistically significant covariate. The visual predictive check of the final model showed good model performance. CONCLUSION: Our results imply that BED formalism could aid in therapy individualisation. The larger thyroid volume is associated with a lower probability of a successful outcome. PMID:34273482 | DOI:10.1016/j.ejps.2021.105942 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Improving the prediction of persistent and recurrent differentiated thyroid cancer using the American Thyroid Association 2015 risk stratification system

xlomafota13 shared this article with you from Inoreader Improving the prediction of persistent and recurrent differentiated thyroid cancer using the American Thyroid Association 2015 risk stratification system Via radioactive iodine Hormones (Athens). 2021 Aug 12. doi: 10.1007/s42000-021-00313-2. Online ahead of print. ABSTRACT PURPOSE: The 2015 American Thyroid Association risk stratification system (ATA RSS) is used in patients with differentiated thyroid carcinoma (DTC) to assess their risk of persistent/recurrent disease. Our aims were to validate the 2015 ATA RSS in a registry of DTC patients and to examine whether the addition of factors not included in it, such as pre-radioactive iodine therapy stimulat ed thyroglobulin (pre-RAI sTg), gender, and age could increase its predictive ability. METHODS: We studied 403 patients with DTC, treated at a tertiary center from 1990 to 2018 and subjected to total thyroidectomy. All patients had received RAI therapy, except those with low-risk papillary microcarcinoma. RESULTS: Of our patients, 81.9% were women and 91.1% had papillary thyroid carcinoma. After a median follow-up of 5.0 years, 53 cases of persistent and 21 cases of recurrent disease were recorded. The proportion of variance explained (PVE) regarding the outcome (presence or absence of recurrent/persistent disease) using the 2015 ATA RSS alone was 18.3% (persistence) and 16.9% (recurrence), increasing to 74.4% and 52.0%, respectively, when pre-RAI sTg was added to the logistic regression model. Gender and age were not associated with the disease outcome. In ROC analysis, pre-RAI sTg had a high predictive value for persistent (AUC 0.983, 95% CI 0.962-1.000) and recurrent disease (AUC 0.856, 95% CI 0.715-0.997). The optimal cut-offs and sensitivity, specificity, and positive and negative predictive value for pre-RAI sTg were the following: for persistence 12.75 ng/ml, 100%, 90.5%, 64%, and 100%, and for recurrence 8.05 ng/ml, 77.8%, 85.5%, 36.8%, and 97%. CONCLUSIONS: The 2015 ATA RSS displayed moderate performance in predicting recurrent/persistent disease in patients with DTC, which improved with the inclusion of pre-RAI sTg values; pre-RAI sTg was an independent predictor of the disease outcome, with high negative prognostic value. PMID:34383288 | DOI:10.1007/s42000-021-00313 -2 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.