Three-dimensional morphologic classifications and analysis of canal isthmuses in permanent molars

xlomafota13 shared this article with you from Inoreader Three-dimensional morphologic classifications and analysis of canal isthmuses in permanent molars Via radiol anat Surg Radiol Anat. 2021 Jul 10. doi: 10.1007/s00276-021-02796-5. Online ahead of print. ABSTRACT PURPOSE: To investigate the three-dimensional morphology of isthmuses in molars according to their boundary characteristics using micro-computed tomography (micro-CT). METHODS: Micro-CT reconstructed images of 248 molars were evaluated. Isthmuses were classified into four types based on the boundary characteristics: isthmus with roof, isthmus with floor, band-shaped isthmus, and isthmus without boundary. The tooth and root with isthmuses, the number and location of the isthmuses in the root, and the canal configurations were recorded. The maximum of the major diameter of all canal cross-sections in one isthmus (dmax), the minor diameter of the canal in same cross-section (dmin), the distance between the dmax cross-section and apex (Dm-a), isthmus length (Li), and distance from the isthmus ending cross-section to apex (De-a) were measured and analysed with a significance threshold set to 5%. RESULTS: Isthmuses were present in 75.4% specimens. The four types of isthmuses were found in various molars and roots. Their distribution in different root locations and canal configurations was significantly different. The dmax, dmin, Li, and De-a were analysed according to different molars and different isthmus types; their respective median values were 2.508 mm, 0.07 mm, 3.09 mm, and 3.96 mm. CONCLUSION: The three-dimensional classification of isthmuses according to the boundary characteristics provides a comprehensive picture of the isthmus in molars. Their corresponding distributions in different molars, location in roots, and canal configurations will be helpful in predicting the type of isthmus based on the tooth position and canal configurations. PMID:34245350 | DOI:10.1007/s00276-021-02796-5 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A comprehensive morphometric analysis of crista galli for sex determination with a novel morphological classification on computed tomography images

xlomafota13 shared this article with you from Inoreader A comprehensive morphometric analysis of crista galli for sex determination with a novel morphological classification on computed tomography images Via radiol anat Surg Radiol Anat. 2021 Jul 10. doi: 10.1007/s00276-021-02799-2. Online ahead of print. ABSTRACT PURPOSE: This study aimed to examine the morphometry of the crista galli (CG) on paranasal sinus computed tomography (PNCT) images to develop a new approach of morphological classification with objective radiological criteria and to investigate the relationship of morphometric and morphological characteristics with gender. METHODS: The height, width, and length of the CG wer e measured on the PNCT images of 533 subjects (266 males, 267 females). Based on the dimensions and the presence of the cavitary component of the CG, the CG was classified into three morphological types. The success of CG dimensions and new morphological classification of CG in the determination of gender was evaluated with ROC and Paired Logistic Regression analyses. RESULTS: The morphometric cutoff values of the height, width, and length of the CG for the estimation of gender were determined as 15.15, 3.45, and 13.25 mm, respectively. CG length (accuracy 83.7%) showed more successful classification rate on gender determination as compared to height (accuracy: 81.4%), and width (accuracy 81.2%) of the CG. The presence of ossified type CG accurately identified the male sex at a rate of 88.7%, and teardrop type CG determined female sex at a rate of 82.9%. Tubular type CG identified male sex correctly at the rate of 65.8%. CONCLUSION: The height, length, and width measurem ents of CG on PNCT images and the new morphological types recommended in this study can be used in the determination of gender with high accuracy rates. PMID:34245351 | DOI:10.1007/s00276-021-02799-2 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Acoustic Voice Analysis of Normal and Pathological Voices in Indian Population Using Praat Software

xlomafota13 shared this article with you from Inoreader Acoustic Voice Analysis of Normal and Pathological Voices in Indian Population Using Praat Software Via Otolaryngology Indian Abstract Acoustic voice analysis is still a valuable technique which enables voice clinicians to compare voices to differentiate them into normal and abnormal. The present study was undertaken to standardize acoustic voice parameters in normal healthy adult individuals and gender comparison among them and also acoustic voice analysis of pathological voices and it's comparison with normal healthy voices. Voice samples of vowels /a/, /i/ and /u/ of 80 normal healthy adults (males = 40, females = 40) of control group and 40 patients with dysphonic voice of case group collected and acoustic voice parameters were extracted by using Praat software. There were statistically significant higher values of fundamental frequency (F0) in females, while jitter local (%), shimmer local (%) and harmonic to noise ratio (HNR) had no gender differences in normal healthy voices. Pathological voices of case group subjects with laryngeal pathologies had statistically significant high er values of jitter local (%), shimmer local (%) and lower values of HNR as compare to normal healthy voices of control group. Objective voice analysis by using Praat software is convenient, reliable and cost effective method. This study establishes normative acoustic voice parameters in normal healthy adults. There are no gender differences in adult healthy voices except fundamental frequency (F0), which is higher in females. Patients who are with dysphonic voices due to laryngeal pathologies had altered values of acoustic parameters compared to normophonic adults and clinicians can precisely differentiate pathological voices from normophonics. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Sentinel lymph node biopsy versus elective neck dissection in squamous cell carcinoma of the oral cavity with a clinically N0 neck: A systematic review and meta‐analysis of prospective studies

xlomafota13 shared this article with you from Inoreader Sentinel lymph node biopsy versus elective neck dissection in squamous cell carcinoma of the oral cavity with a clinically N0 neck: A systematic review and meta‐analysis of prospective studies Via Head & Neck Abstract Sentinel lymph node biopsy (SLNB) is an emerging strategy for managing early-stage oral squamous cell carcinoma (SCC) with a clinically N0 (cN0) neck. However, the role of SLNB in this scenario is debatable. Herein, relevant literature was systematically reviewed, and a meta-analysis was performed to evaluate the potential dividends of SLNB compared to elective neck dissection (END) for these patients. The meta-analysis, including six prospective studies, showed comparable results of the two management strategies in terms of regional recurrence (risk ratio [RR] = 0.99; 95% confidence interval [CI], 0.58–1.70), 5-year disease-free survival (RR = 0.99; 95% CI, 0.87–1.11), and 5-year overall survival (RR = 1.01; 95% CI, 0.90–1.13). Fewer adverse events occurred in the SLNB arm than in the END arm (RR = 0.12; 95% CI, 0.02–0.70). Overall, SLNB results in as favorable an oncologic prognosis for patients with cN0 oral SCC as END, while sign ificantly lessening side effects and unnecessary surgeries. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Pretherapeutic Predictive Factors for Histological High‐Grade Parotid Gland Carcinoma

xlomafota13 shared this article with you from Inoreader Pretherapeutic Predictive Factors for Histological High‐Grade Parotid Gland Carcinoma Via The Laryngoscope Objective The histological grade of parotid gland carcinoma (PGC) is an important prognostic factor; however, the diagnosis prior to treatment has been challenging to make. This study aimed to investigate whether the pretreatment clinical findings, including hematological inflammatory, nutritional, and immune markers, could predict the histological grade of PGC. Study Design Retrospective study. Methods We retrospectively enrolled 111 patients with PGC and evaluated the correlation between histological grade and pretreatment clinical findings such as age, sex, tumor staging, facial nerve paralysis, pain or tenderness, adhesion to the surrounding tissues or tumor immobility, and hematological markers. Results Sixty patients (54%) were diagnosed with histological high-grade PGC. Univariate analysis revealed that age, T classification, N classification, TNM stage, facial nerve paralysis, adhesion/immobility, C-reactive protein (CRP), and CRP-to-albumin ratio (CAR) were significant predictors of PGC histological grade. On multivariate analysis, high T classification (T3, 4), high N classification (≥1), and elevated CRP (≥0.22 mg/dL) were independent predictors of high-grade PGC. Conclusions Pretreatment T classification, N classification, and CRP are significant predictors of the histological grading of PGC. Our results are useful for treatment planning and obtaining appropriate informed consent from the patients before treatment. Level of Evidence 4 Laryngoscope, 2021 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Auditory Event Related Potentials in children with autism spectrum disorder

xlomafota13 shared this article with you from Inoreader Auditory Event Related Potentials in children with autism spectrum disorder Via cortical auditory Int J Pediatr Otorhinolaryngol. 2021 Jun 30;148:110826. doi: 10.1016/j.ijporl.2021.110826. Online ahead of print. ABSTRACT OBJECTIVE: To analyze auditory cortical processing in high functioning ASD individuals. METHODS: Thirty individuals were included in the study (15 with Autism Spectrum Disorder and 15 with typical development), and their Auditory Event Related Potentials evaluation, elicited with tone burst and speech stimuli, were analyzed. RESULTS: There were no significant differences between individuals with high-functioning Autism Spectrum Disorder without intellectual disability and those with typical development in the auditory Event-related Potentials elicited with tone bursts or speech stimuli. CONCLUSIONS: The results of Auditory Event Related Potentials did not show any change at the cortical level in individuals with Autism Spectrum Disorder. PMID:34246067 | DOI:10.1016/j.ijporl.2021.110826 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Diagnostic Usefulness of Flexible Fibroscopy Biopsy in Suspected Lesions of the Otolaryngological Area

xlomafota13 shared this article with you from Inoreader Diagnostic Usefulness of Flexible Fibroscopy Biopsy in Suspected Lesions of the Otolaryngological Area Via Otolaryngology Indian Abstract The efficiency in the management of patients with suspected malignant lesions represents the main objective of the oncology of head and neck. Flexible nasopahyngolaryngoscopy with working channel allows to quickly and safely assess and obtain histological samples of this type of lesion. Our objective is to describe the usefulness of this technique in lesions suggestive of malignancy in terms of efficiency, sensitivity and specificity. A retrospective study was carried out over a period of time from December 2014 to December 2019, including patients biopsied with flexible fibroscopy of lesions of debut suspected of malignancy. Here we assess the location of the lesion, the histological results, the diagnostic time and the epidemiological variables. 104 patients were included in the study. More than half of the lesions, 55.2% (57), were located in the larynx; 57.7% (60) resulted positive for malignancy in the flexible fiberscope biopsy; 19.2% (20) were taken to the operating room to get biopsied under general anesthesia resulting in 7.4% (14) positive for malignancy, which shows a sensitivity of the test of 81%. In our sample, a diagnostic time of 15 days was obtained. Considering our results, the few complications and the revised literature, flexible fiberscope biopsy with working channel is an efficient procedure for the management of oncological patients of head and neck. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

An eclectic Voice Therapy Program for the Treatment of Hyperfunctional Voice Disorders (HFVD)

xlomafota13 shared this article with you from Inoreader An eclectic Voice Therapy Program for the Treatment of Hyperfunctional Voice Disorders (HFVD) Via Journal of Voice An eclectic voice therapy program includes sequenced and structured set of exercises combining direct and indirect intervention methods. Tailor-made exercise prescription with specific cultural adaptations are needed to provide a holistic change to voice quality.1 This study detailed the construction of an exercise prescription for participants with hyperfunctional voice disorder [HFVD] in the Indian context. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Plasma Asymmetrıc Dımethylargınıne (ADMA) and Nıtrıc Oxıde (NO) Levels ın Patıents wıth Chronıc Pansınusıtıs

xlomafota13 shared this article with you from Inoreader Plasma Asymmetrıc Dımethylargınıne (ADMA) and Nıtrıc Oxıde (NO) Levels ın Patıents wıth Chronıc Pansınusıtıs Via Otolaryngology Indian Abstract Chronic pansinusitis is a mucosal inflammation of the nose and all paranasal sinuses with severe inflammation of the upper airways. Asymmetric dimethylarginine (ADMA) is associated with oxidative stress. In this study, we aimed to examine the plasma levels and importance of ADMA and nitric oxide (NO) in patients with chronic pansinusitis. The study was conducted with a total of 64 patients. The study group included a total of 40 patients with chronic pansinusitis. (18 females, 22 males) (mean age 32.27 ± 10.02). The control group consisted of 24 patients (11 females and 13 males). The mean age of the patients in the control group was 31.35 ± 6.05 years. Nasal endoscopic examinations were performed in patients with a history of chronic pansinusitis and symptoms of chronic pansinusitis. Later, the diagnosis of chronic pansinusitis was confirmed with coronal paranasal sinus Computed tomography scans. Plasma ADMA levels were measured by ELISA method and NO levels were measured by Griess method. Plasma ADMA and NO levels of the patients and healthy volunteers were measured and the mean plasma levels of the two groups were compared. ADMA levels were significantly higher in the group with chronic pansinusitis compared to the control group (1.23 ± 0.41 μM and 0.28 ± 0.06 μM, respectively) (p < 0.001), while NO levels were significantly lower in the patient group compared to the control group (7.06 ± 1.07 μM and 12.25 ± 0.95, μM, respectively) (p < 0.001). Our results show that the increase in ADMA levels and the decrease in NO levels are associated with chronic pansinusitis. According to these results, increased plasma levels of ADMA in chronic pansinusitis may be useful in clinical use as a sign of increased oxidative stress. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Human immunodeficiency virus and lymphoma

xlomafota13 shared this article with you from Inoreader Human immunodeficiency virus and lymphoma Via Association française pour l'étude du cancer Bull Cancer. 2021 Jul 7:S0007-4551(21)00180-6. doi: 10.1016/j.bulcan.2021.03.014. Online ahead of print. ABSTRACT Lymphomas remain a leading cause of morbidity and mortality for HIV-positive patients. The most common lymphomas include diffuse large B-cell lymphoma, Burkitt lymphoma, primary effusion lymphoma, plasmablastic lymphoma and Hodgkin lymphoma. Appropriate approach is determined by lymphoma stage, performans status, comorbidities, histological subtype, status of the HIV disease and immunosuppression. Treatment outcomes have improved due to chemotherapy modalities and effective antiretroviral therapy. This review summarizes epidemiology, pathogenesis, pathology, and current treatment landscape in HIV associated lymphoma. PMID:34246454 | DOI:10.1016/j.bulcan.2021.03.014 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Preoperative versus postoperative radiotherapy in soft tissue sarcomas: State of the art and perspectives

xlomafota13 shared this article with you from Inoreader Preoperative versus postoperative radiotherapy in soft tissue sarcomas: State of the art and perspectives Via Association française pour l'étude du cancer Bull Cancer. 2021 Jul 7:S0007-4551(21)00167-3. doi: 10.1016/j.bulcan.2021.03.012. Online ahead of print. ABSTRACT Radiation therapy is a standard treatment for limbs soft tissue sarcomas. Preoperative versus postoperative radiotherapy has been a controversial topic for years. With preoperative irradiation, the treatment volume is more limited, the delivered dose possibly lower and the tumor volume easier to delimit. Only one randomized trial compared these two irradiation sequences. The results in terms of local control and survival were equivalent but the risk of acute postoperative complications was higher if irradiation was administered before surgery. However, in the latest update of this trial, patients who received adjuvant irradiation exhibited more severe late toxicity than those treated preoperatively. In addition, with modern irradiation techniques such as conformal with image-guided intensity modulated radiotherapy and flap coverage techniques, the incidence of complications after preoperative irradiation were lower than historically published rates. Locally advanced proximal sarcomas and the failure of other neoadjuvant treatments are nowadays classical indications for preoperative irradiation. As with other neoadjuvant treatments, induction radiotherapy must be personalized according to the histological subtype, the tumor site and the benefit/risk ratio, which is best appreciated by a multidisciplinary surgical and oncological team in a specialized center in the management of soft-tissue sarcomas. PMID:34246458 | DOI:10.1016/j.bulca n.2021.03.012 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.