Bilirubin is a specific marker for the diagnosis of acute appendicitis

xlomafota13 shared this article with you from Inoreader Bilirubin is a specific marker for the diagnosis of acute appendicitis Via Experimental and therapeutic medicine Exp Ther Med. 2021 Oct;22(4):1056. doi: 10.3892/etm.2021.10490. Epub 2021 Jul 23. ABSTRACT Total serum bilirubin and other biochemical parameters have been associated with acute appendicitis, mainly in complicated cases. The present study aimed to evaluate the role of biochemical parameters in the diagnosis of acute appendicitis, and to further investigate the role of bilirubin as a diagnostic marker irrespective of the severity of the pathology. All recorded cases of appendicectomies in a 1-year period in a single institution were reviewed. The median values of white cell count, C-reactive protein and total serum bilirubin on admission were associated with final histology, and their respective rates of abnormal and normal values were compared between patients who were proven to have negative histology and patients who were proven to have acute appendicitis. A total of 300 patients were studied. Median total serum bilirubin, white cell count and C-reactive protein on admission were significantly associated with acute appendicitis (P<0.001). Respective rates of normal and abnormal values were significantly associated with final histology (P<0.001). Total serum bilirubin demonstrated higher specificity (0.88) but lower sensitivity (0.26) and diagnostic accuracy (0.40) for acute appendicitis. In conclusion, total serum bilirubin on admission should be considered in the diagnostic workup to confirm rather than exclude appendicitis, without focusing on subgroups of specific severity of the disease. White cell count and C-reactive protein may also contribute to the diagnostic work-up, although with limited accuracy. PMID:34434270 | PMC:PMC8353631 | DOI:10.3892/etm.2021.10490 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

IL-17F promotes osteoblastic osteogenesis via the MAPK/ERK1/2 signaling pathway

xlomafota13 shared this article with you from Inoreader IL-17F promotes osteoblastic osteogenesis via the MAPK/ERK1/2 signaling pathway Via Experimental and therapeutic medicine Exp Ther Med. 2021 Oct;22(4):1052. doi: 10.3892/etm.2021.10486. Epub 2021 Jul 23. ABSTRACT Osteoimmunology is a field that focuses on the interactions between the skeletal and immune systems, and has become a focus of research over the years. The role of interleukin (IL)-17F, a proinflammatory cytokine, in bone regeneration and its signal transduction are not completely understood. The aim of the present study was to evaluate the function of IL-17F and the possible mechanisms underlying IL-17F in osteoblasts in vitro. Osteoblasts derived from newborn rats were treated with various concentrations of IL-17F. The pro-osteogenic effects of IL-17F were assessed at the cellular and molecular level. The results demonstrated that IL-17F promoted osteoblast proliferation, differentiation and mineralization. Reverse transcription-quantitative PCR and western blotting indicated that IL-17F treatment upregulated osteogenesis-related factors , including bone morphogenetic protein-2, Runt-related transcription factor-2 (Runx2) and Osterix, and downregulated Noggin compared with the control group. Subsequently, whether the IL-17F receptors, IL-17 receptor (IL-17R) A and IL-17RC, served a role in the effects of IL-17F on osteoblasts was investigated. The mRNA expression levels of IL-17RA and IL-17RC were upregulated in IL-17F-treated osteoblasts compared with control osteoblasts. Furthermore, U0126, a MAPK/ERK1/2 inhibitor, was utilized to investigate the mechanisms underlying IL-17F. The results indicated that compared with the control group, IL-17F increased the protein expression of phosphorylated-ERK1/2, Runx2 and Osterix, whereas U0126 reversed IL-17F-mediated effects. Collectively, the results of the present study suggested that IL-17F promoted osteoblastic osteogenesis via the MAPK/ERK1/2-mediated signaling pathway. IL-17F promoted osteogenesis, including proliferation, differentiation and mineralization activity, i ndicating that IL-17F may serve as a potential therapeutic target for osteoblast-mediated bone loss disease. PMID:34434266 | PMC:PMC8353634 | DOI:10.3892/etm.2021.10486 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Association between obstructive sleep apnea and thyroid cancer incidence: a national health insurance data study

xlomafota13 shared this article with you from Inoreader Association between obstructive sleep apnea and thyroid cancer incidence: a national health insurance data study Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Aug 25. doi: 10.1007/s00405-021-07050-7. Online ahead of print. NO ABSTRACT PMID:34435245 | DOI:10.1007/s00405-021-07050-7 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Metastatic Follicular Thyroid Carcinoma Presenting as Thoracic Cord Compression

xlomafota13 shared this article with you from Inoreader Metastatic Follicular Thyroid Carcinoma Presenting as Thoracic Cord Compression Via radioactive iodine J Med Cases. 2021 May;12(5):177-180. doi: 10.14740/jmc3658. Epub 2021 Mar 5. ABSTRACT Follicular thyroid carcinoma (FTC) is an uncommon cancer and the incidence of FTC is higher in endemic areas of iodine deficiency or endemic goiter. Up until the 1990s Fiji was listed as an iodine deficient country. We report a rare case of a 53-year-old native Fijian man who presented to our hospital with spinal cord compression due to a metastatic deposit of an undiagnosed FTC. He underwent emer gent neurosurgical treatment for his cord compression, with histology of the lesion at the level of T5 identifying metastatic FTC. Despite the emergent surgery, he did not have any neurological recovery. Total thyroidectomy confirmed the presence of a large left-sided FTC and the patient was assessed for radioactive iodine treatment. Nuclear medicine imaging revealed extensive distant bony metastatic disease. Unfortunately due to his significant distant disease burden, he was unable to undergo radioactive iodine ablation therapy. After significant allied health input he was discharged home with community palliative care input. PMID:34434453 | PMC:PMC8383535 | DOI:10.14740/jmc3658 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Acute Vision Loss From IgG4-Related and Bacterial Rhinosinusitis After COVID-19

xlomafota13 shared this article with you from Inoreader Acute Vision Loss From IgG4-Related and Bacterial Rhinosinusitis After COVID-19 Via JAMA Otolaryngology–Head & Neck Surgery Online First This case report describes a man in his 70s who presented to the emergency department with a headache for 2 weeks and vision loss in the right eye for 2 days and was subsequently diagnosed with IgG4-related and Streptococcus constellatus rhinosinusitis. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Continuous Local Anesthetic Wound Infusions as Postoperative Standard of Care in Patients With Head and Neck Cancer

xlomafota13 shared this article with you from Inoreader Continuous Local Anesthetic Wound Infusions as Postoperative Standard of Care in Patients With Head and Neck Cancer Via JAMA Otolaryngology–Head & Neck Surgery Online First To the Editor We thank Gostian et al for their study demonstrating a reduction in postoperative pain when continuous wound infusion (CWI) was used after head and neck oncological resections. The authors call for CWI to be assimilated into the multimodal postoperative analgesic concept in patients. However, prior to widespread implementation, we find it prudent to draw attention to a few caveats to the study's conclusions. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Olfactory Bulb Volume—A Novel Preclinical Biomarker for Smell Loss and Neurodegenerative Disease

xlomafota13 shared this article with you from Inoreader Olfactory Bulb Volume—A Novel Preclinical Biomarker for Smell Loss and Neurodegenerative Disease Via JAMA Otolaryngology–Head & Neck Surgery Online First Neurodegenerative disorders, such as Alzheimer dementia and Parkinson disease, are disabling diseases that present a burden on society that rivals the costs of cancer and heart disease. Although current therapies are often unsuccessful at reversing the progression of these diseases, early detection in patients who are at risk of neurodegenerative disease could allow for timely interventions to delay and minimize the loss of brain function over time. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Evaluation of the Neuroanatomical Basis of Olfactory Dysfunction

xlomafota13 shared this article with you from Inoreader Evaluation of the Neuroanatomical Basis of Olfactory Dysfunction Via JAMA Otolaryngology–Head & Neck Surgery Online First This cross-sectional study evaluates the role of the components of the olfactory pathway structures in impaired olfactory function. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Maternal Thyroid Hormone Programs Cardiovascular Functions in the Offspring

xlomafota13 shared this article with you from Inoreader Maternal Thyroid Hormone Programs Cardiovascular Functions in the Offspring Via liebertpub1 Thyroid, Ahead of Print. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Predictive Value of Serum Thyroglobulin for Structural Recurrence Following Lobectomy for Papillary Thyroid Carcinoma

xlomafota13 shared this article with you from Inoreader Predictive Value of Serum Thyroglobulin for Structural Recurrence Following Lobectomy for Papillary Thyroid Carcinoma Via liebertpub1 Thyroid, Ahead of Print. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Thyroglossal Duct Cyst Located in the Thyroid Gland Misdiagnosed With Thyroid Carcinoma: A Case Report and Literature Review

xlomafota13 shared this article with you from Inoreader Thyroglossal Duct Cyst Located in the Thyroid Gland Misdiagnosed With Thyroid Carcinoma: A Case Report and Literature Review Via ear nose throat Ear Nose Throat J. 2021 Aug 26:1455613211040583. doi: 10.1177/01455613211040583. Online ahead of print. ABSTRACT The clinicopathologic features of thyroglossal duct cyst when it develops ectopically in the thyroid gland remain unclear because of its rarity, which makes diagnosis difficult. Clinical diagnosis and treatment should not disregard the possibility of thyroglossal cysts located in the thyroid gland. We here report the current case to prepare others and provide data for the diagnosis and treatment of this kind of disease. PMID:34433310 | DOI:10.1177/014556132110 40583 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

High-grade salivary gland cancer: is surgery followed by radiotherapy an adequate treatment to reach tumor control? Results from a tertiary referral centre focussing on incidence and management of distant metastases

xlomafota13 shared this article with you from Inoreader High-grade salivary gland cancer: is surgery followed by radiotherapy an adequate treatment to reach tumor control? Results from a tertiary referral centre focussing on incidence and management of distant metastases Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Aug 26. doi: 10.1007/s00405-021-07024-9. Online ahead of print. ABSTRACT PURPOSE: Salivary Gland cancer (SGC) is a rare and heterogenous group of tumors. Standard therapeutic options achieve high local but poor distant control rates, especially in high-grade SGC. The aim of this monocentric study was to evaluate patterns of recurrence and its treatment options (local ablative vs. systemic) in a homogenously treated patient population with high-grade SGC after surgery and radio(chemo)therapy. METHODS: Monocentric, retrospective study of patients with newly diagnosed high-grade salivary gland cancer. We retrospectively reviewed clinical reports from 69 patients with high-grade salivary gland cancer in a single-center audit. Survival rates were calculated using the Kaplan-Meier method and prognostic variables were analyzed (univariate analysis: log-rank test; multivariate analysis: Cox regression anal ysis). RESULTS: The median time of follow-up was 31 months. After 5 years, the cumulative overall survival was 65.2%, cumulative incidence of local recurrence was 7.2%, whereas the cumulative incidence of distant metastases was 43.5% after 5 years. 30 of 69 patients developed distant metastases during the time of follow-up, especially patients with adenoid cystic carcinoma, salivary duct carcinoma, adenocarcinoma NOS and acinic cell carcinoma with high-grade transformation. The most common type of therapy therefore was chemotherapy (50%). 85.7% of patients with local ablative therapy of distant metastases show disease progression during follow-up afterwards. CONCLUSION: With surgery and radio-chemotherapy, a high rate of loco-regional control is reached, but over 40% of patients develop distant metastases in the further follow-up which usually present a diffuse pattern involving in a diffuse metastases. Therefore, in the future, intensified interdisciplinary combination therapies even in the first-line treatment in certain subtypes of high-grade SGC should be investigated. PMID:34436631 | DOI:10.1007/s00405-021-07024-9 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.