Anionic surfactants and commercial detergents decrease tight junction barrier integrity in human keratinocytes

As the largest organ of the body, the skin acts as an essential barrier that protects against and/or minimizes damage from environmental and endogenous factors to maintain internal homeostasis.1 The skin barrier plays key roles in immune surveillance and in preventing penetration of microbes, toxins, pollutants, and allergens.2 This important barrier function resides mainly in the epidermis, which has 2 major barrier structures: the stratum corneum3 and tight junctions (TJs),4 the latter of which seal adjacent keratinocytes in the stratum granulosum.

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